ID A0A3P8ZNV0_ESOLU Unreviewed; 611 AA.
AC A0A3P8ZNV0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Vitronectin {ECO:0000313|Ensembl:ENSELUP00000030093.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000030093.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000030093.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000030093.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8ZNV0; -.
DR Ensembl; ENSELUT00000009172.2; ENSELUP00000030093.1; ENSELUG00000007205.2.
DR GeneTree; ENSGT00530000063751; -.
DR Proteomes; UP000265140; LG01.
DR Bgee; ENSELUG00000007205; Expressed in liver and 10 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00094; HX; 1.
DR Gene3D; 4.10.410.20; -; 1.
DR Gene3D; 2.110.10.10; Hemopexin-like domain; 2.
DR InterPro; IPR000585; Hemopexin-like_dom.
DR InterPro; IPR036375; Hemopexin-like_dom_sf.
DR InterPro; IPR018487; Hemopexin-like_repeat.
DR InterPro; IPR020436; SMB_chordata.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR22917; HEMOPEXIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22917:SF7; VITRONECTIN A; 1.
DR Pfam; PF00045; Hemopexin; 3.
DR Pfam; PF01033; Somatomedin_B; 1.
DR PRINTS; PR00022; SOMATOMEDINB.
DR SMART; SM00120; HX; 4.
DR SMART; SM00201; SO; 1.
DR SUPFAM; SSF50923; Hemopexin-like domain; 2.
DR SUPFAM; SSF90188; Somatomedin B domain; 1.
DR PROSITE; PS51642; HEMOPEXIN_2; 4.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 13..55
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT REPEAT 160..204
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REPEAT 205..252
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REPEAT 253..310
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REPEAT 546..601
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REGION 63..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 611 AA; 71019 MW; 581048F73B793EDF CRC64;
MLPDLRVPIR LTYSESCMDR CENGFESVKK CQCDTMCRYY RSCCSDYETI CLMTTRGDTF
EFAEDDDGPF PPTQITPWTD DGTSVSSGRQ WSQPTQSNEA RVIVPQNTSV IVTEAAPVTT
EAQNTTAEEA ATMQPPVGIP KAPVATPKTP VDPDSELCSG RPWDSLMQMK NGSVYAFRGQ
YFFELDDKAV MPGYPKLIED IWGIRGPIDA AFTRMNCQGN TYIFKGNKYW RFDDGVLEKD
YPRDISVGFD KIPDDLDAAF AIAAPGHHGK EKAYFFKGDQ YYQYEFLNQP SHEECTKMSA
RSPSALFRAY TDIYYDSWEE LFNMLFRGIP NHHDGHRFIN KDWVGIKAPV DAVLAGRLYL
TPRHLPPPLP PIWDSSTGRR HPWDQQYGQQ YGQQGQQYGQ QYGQQYGQQG QQYGQQYGQQ
YGQQGQQYGQ QGQQRGQQWG RYRNRRQSYW GAGSGMAMGQ AFREKGMAMG HAFGKREIDL
GQKMFGGWDT PQTDTRDEDR ERDRRRDDQD RWNNQDRRND QDRRNDQDRR NDQDRRRDGY
NYDSTYNKWR AYREFINRRQ PVQSVYFFKG DKYFRVDLKT KRVDTARPPY PRSIGKYWLG
CPDQHHGAER K
//
