ID A0A3P8ZPF4_ESOLU Unreviewed; 2711 AA.
AC A0A3P8ZPF4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Filamin C {ECO:0000313|Ensembl:ENSELUP00000030227.1};
GN Name=FLNC {ECO:0000313|Ensembl:ENSELUP00000030227.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000030227.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000030227.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000030227.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR RefSeq; XP_012994360.1; XM_013138906.2.
DR STRING; 8010.ENSELUP00000030227; -.
DR Ensembl; ENSELUT00000008883.2; ENSELUP00000030227.1; ENSELUG00000007451.2.
DR GeneID; 105021804; -.
DR GeneTree; ENSGT00940000153588; -.
DR InParanoid; A0A3P8ZPF4; -.
DR OMA; VPTHEGY; -.
DR OrthoDB; 298396at2759; -.
DR Proteomes; UP000265140; LG19.
DR Bgee; ENSELUG00000007451; Expressed in bone element and 11 other cell types or tissues.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 24.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR PANTHER; PTHR38537:SF17; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 24.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 24.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 24.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 24.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 47..153
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 170..273
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 283..381
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 383..481
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 482..578
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 579..671
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 675..771
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 772..874
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 875..974
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 975..1070
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1071..1163
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1164..1258
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1259..1358
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1359..1451
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1452..1547
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1548..1644
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1657..1747
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1775..1833
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1833..1925
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1923..2012
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2015..2107
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2220..2289
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2292..2384
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2386..2479
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2483..2575
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2616..2710
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2224..2250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2227..2245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2711 AA; 289932 MW; 4529D7DAFC7ECEE4 CRC64;
MTSNNTHYYD DSQPPQYYQG PDNFEGDEED EMPATEKDLA EDAPWKKIQQ NTFTRWCNEH
LKCVNKTITD LQKDFGDGLK LIGLLEVLSQ KKMYRKHHAR PNFRQMKLEN VSVALEFLDR
EHIKLVSIDS KAIVDGNLKL ILGLIWTLIL HYSISMPMWE DEDDEEAKKL TPKQRLLGWI
QNKVPELPIN NFHRDWRDGK ALGALVDNCA PGLCPDWQAW DPNQPVENAR EAMQQADDWL
GVPQVIAPEE IVDPDVDEHS VMTYLSQFPK AKLKPGAPLK PRGVQLYPKK AKAYGPGIEP
HGNMVLRPAV FTVETVEAGQ AEVLVYVTDP EGHTEEARVV FNNDRKRTYT VSYVPKVEGL
HKVKVLFAGQ DIDKSPYMVN VAKALGDAKK VHARGPGLEP TGNVANKPTY FDIYTAGAGN
GDVSVIIVDP EGKKDTVEVI LESKGDSVFR CTYRPVLEGP HIIHVLFAGQ EIPKSHFRVN
ISEAVNANAC RATGRGLQPK GVRVKEVADF KVFTKGAGSG DLRVSVLGPS GAEQPVKVRD
VGDGVYECEY LPSHPGKYTV HITWGGQPIP RSPFEVEVSE KAGLQKVRAW GPGLVTGQVG
KSADFVVEAI GTEVGTLGFS IEGPSQAKIE CDDKGDGSCD VRYWPTEPGD YAVHVICDDE
DIKDSPFMAH ILPAANDCFP EKVRAFGPGL EPTGVIVNKP AEFTIDGRLA GKGQLKIYAQ
DSEGVTIDLK ITDKGDGTFL CVYIPVKPIK HTIIITWGDV NVPNSPFRVI VGEGCHPDKV
KVYGPGVEKT GLKANEPTYF TVDCAEAGQG DISIGIKCAP GVVGPAEADI DFDIIKNDND
TFTVKYTPPG AGKYTIMVLF AEQEIPISPF RVKVDPSHDA GRVRAEGPGL NKTGVEVGTP
THFTIFTKGA GKAKPEVQFT AAGLKGEAVR DFEIIDNHDY SYTVKYTAVQ QGQMTITVTY
GGDPIPKSPF HVTVAPALDL GKVKVTGLDT KVEVGKDQEF SINTKGAGGQ GKVAVKMTSP
SGRPIPCKIE SDAAIGAHSV KYIPPEEGPY KVEVSYDGNP VPGSPFAVEG VMPADPSKVR
AYGPGLKGGI VGQPAPFTID TKGAGAGGLG LTVEGPCEAK IECQDNGDGT CSVAYLPTEA
GEYAINILFG EQHIPGSPFK AAVKPCLDPS KVTASGPGLQ KAKAGEPAYF TVDCTGAGEA
ELTIEIVSQS GAHAEVHIQK TTEGTFSVTY IPPFHGTHTI TIKYGGHVVP KFPTVIQVEP
AVDTSGVQVY GPGVEPRGVL KEVTTHFIVD ARKTTKTGGD HVKACIINPS GTNTETYITD
KGDGTYRVEY TAFEDGMHLI EVLYDDVAVP KSPFRVSVVE GCDPTRVRAY GPGLEGGLIN
KPNCFTVETR GAGTGGLGLT IEGASEAKMT CKDNKDGSCS VEYVPFTPGE YDVNISFGGH
PIPGSPFRVP VRDVVDPSKV RCSGPGLGDG VRAHVPQMFT VDATQAGKAP LEVQLTGPSG
SAEPVAVKNN GDGTHTVNYT PAQDGPYTVS VKYADQEVPR SPFKVRCHPA HDASKVRASG
PGLNKSGVPA SLPVEFTIDA RDAGEGLLTV QILDPEGKPK KATIHDNRDG TYTVSYVPDS
TGPYTITIKY GGDEIPYSPY RISALPTGDA SKCLLSVSIG GHALTSGLTK MQAHEETIVS
VDAKAAGKGK VTCSVTTPQG VELDMDVQEN RDGTFDIYYT APEPGKYVIT IRFGGQHIPK
SPFHVTATKE PVVPRDGSDQ FRPLDLVIPF TVQQGPITGE VRMPSGKTAR PHITDNKDGT
ITVKFNPSEK GLHEMDIKYE GNHIPGSPLQ FYVDAMNSGL VTAYGPGLCH GIVNKPATFT
VVTKNAGEGG LSLAVEGPSK AEITCKDNKD GTCTVSYLPT SPGDYNIIVK FDNRHIPGSP
FTAKITGDDS IRTSQLNVGT AADLSLKITE SDLSLLTASI RAPSGNEEPC LLKRLPNRHI
GISFTPKEVG EHEVSVKKSG KHVTNSPFKI QVGQSEIGEA SRVKAFGKGL VEAHTFEMAE
FFVDTRNAGY GGLGLSIEGP SKVDISCEDM EDGTCRVTYC PTEPGNYIIN IKFSDKHIPG
SPFTVKVTGE GRMKESITRK RTAPSIASVG SACGLNLKIP GNWFQMVSAQ ERMTRTFTRS
SHTYTRTERT EISKMRGGET KREVRVEEST QMGGAGGGSP FRDVFGDFLG RESLASFAGI
PATPGETAAQ GSMTANVTSP SGKTEQAEIV DGGDSTYSVR FVPQEMGAHT VNVKYSGQHV
PGSPFQFTVG PLGEGGSHKV RAGGTGLERG VAGAPSEFSI WTREAGAGGL SIAVEGPSKA
EISFEDRKDG SCGVAYVVQE PGDYEVSIKF NNEHIPDSPF IVPIATLSDE ARRITVTSLQ
EKDLKVNQEA TFAVQRNGAR GVVDAKVHTP SGSAEECYVT ELDSDKNAIR FIPRENGVHS
IDVKFNGSHI PGSPFNVRVG EAGQVGDPGM VTAHGPGLEG GCTGVVSEFI VDTCNAGSGA
LSVTIDGPSK VKMDCTECPE GYKVIYTPMA PGNYLITIKY GGPNHIVGSP FKAKVTGTRL
SGGHSLHETS SVLVETVTKT SKVAGAYSSS SSSLSKLNSD ASKVVCRGAG LSTALIGQKN
VFNVDCSKAG TNMLLVGVHG PRIPCEDVYV KHMGNRLYTV TYTVKDQGNY TVIVKWGDES
VPGSPFSVVV P
//
