ID A0A3P8ZQ25_ESOLU Unreviewed; 2741 AA.
AC A0A3P8ZQ25;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=NACHT domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000030964.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000030964.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000030964.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSELUT00000006971.2; ENSELUP00000030964.2; ENSELUG00000008505.2.
DR GeneTree; ENSGT00730000111912; -.
DR InParanoid; A0A3P8ZQ25; -.
DR Proteomes; UP000265140; LG25.
DR Bgee; ENSELUG00000008505; Expressed in head kidney and 15 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.20.58.1200; RNA silencing suppressor P21, N-terminal domain; 7.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR31594; AIG1-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR31594:SF11; LOC100007703 PROTEIN-RELATED; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 4..94
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 208..294
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 2368..2645
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 2645..2737
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
SQ SEQUENCE 2741 AA; 314783 MW; 2EA35BA3FD9F8D2C CRC64;
MACTRQTAKE YVKNGRRRLI GNLQNLSLIV ENLFQSKVIH EEEVSKIQAE IDSFDQTRKI
LDCVTAKGEA ACYELLMILH HTRKRTLNDS ELQYWISCFP FREDTEMTDY LVGSKPCLRY
QTQLKCKARK ISEFTWKQSS GLLPESLRKE VTFSYTPLVL DTDVLSSDSK LKMKSKKCKK
ARPKKMKSFI PTAKQETFPV ELLKMYKKKI LLVGKPGIGK TSVAHQMLKL WSETDHRELD
YMFYFDLGDI SRRKPMSLED LLFNMYSEPK ESKKEVIEDI ISNSENVIII FDGLTDHSSL
SVVKDIEEKL PEAKLVIMCR PEETEDFMMD WPTDWFRVEV KGFCDESIRD YLTKMLNAQP
ESLNSVLNNL ELFSLCHVPM YAQMVVACIY YNTSQPSKQS WTTTKMYINI VRYCIQKHEG
KQLNDTECLI KNREKILSLA EIAFKATQEK TMNLSTLSCN VSNVQFAFLG ALIIVVEPTA
SDTYSAFLHY TMEEFFAALW LLQNPDRIRD VLQKCQTKEG KHTKHLVPYL CGLLNKSNLR
LVDFLVPSEQ INELTDWFFK ELVNTFLLPQ TNQDLADGGA TEFEMDVLFL CQSVYESQST
DACLLLLEKL EHKLDLSGEH LDPHHCYAVS YVISQSAEKQ VGLDLDSCTV SEQGLRLILG
SLKNVRYIGS DPSILCQLWI TLLRGEAEMN FTSLLGLCEN ELHLPVQGES RVFQRAEDVM
KQSLERVNLC LHWDRRTLLS EALNKTILEC LPNINKLCFS PQQDSIGSPE VRREKTFVLN
LCLQAALHEK ETLQTTVEKV LSLSMKYYNE KCDFLLDLYS HVKDYETQTG RSVLPALQPV
YQSASPAVWS IDLSDRKTSL LLEVLKLQPE KKPVELKGWS DEESEVRSFL QCLPYISQLN
FSSKQDSIGS PEVRREKTFV LNLCLQAALH EKETLQTTVK KVLSLSMKYY NEKCDFLLDL
YSHVKDYETQ TGRSVLTALQ PVYQSASPAV WSIDLSDRKT SLLLEVLKLQ PEKKPVELKG
WSDEESEVRS FLQCLPYISQ LRFCPDESEH SEQIQFLVDL LSQAAEWEEE TGEKKLKLVS
SVCSYRTFPF HKEDNSKQSN FLLDLYSHVK DYETQTGRSV LPALQPVYQS APTVWSIDLS
ERKTSLLLEV LKLQPEKKPV ELCDWSDEES DVRSFLQCLP YISQLRFCPD GSKLSKPIQF
LVDLLSQAAV WEEETGEKKL SLVSSVCTYR TFPFHDDDDD DDYKWYQCDF LLDLYSHVKD
YETQTGRSVL PALQPVYQSA SPPVWSIDLS KRKTSLLLEV LKLQPEKKPV KLKGWSDEES
EVKSFVQCLP YISQLRFCPE RSKLSKQIQF LVDLLSQAAD WEEQTGEKKL KLVSSVCTYR
TFPFHKEDNS KQSNFLLDLY SHLKDYETQT GRSVLPALQP VYQSASTAVW SIDLSERKTS
LLLEVLKLQP EKKPVVLKGW SDKESELRSF LQCLPYISQL RLITGFQIKD AWLLLSKLCI
AAAEYETETG ENVLKTLSSM CRYKEYDDDD DDDDYYDDPF IEGDFLLDLC SHVKDYETQT
GRSVLPALQP VYQSAPPVWS IDLSERKTSL LLEVLKLQPE KKPVELKGWS DEESEVRSFL
QCLPYISQLS FTEQYQRRTP EEWRQREKTF LLNVCLQAVI NEQRSLQTTL ETVLSVFEVC
QYQQWDLVLD LYSYVKDYET HTGRSVLPAL QPVYQSAPPV WSIDLSERKT SILLEVLKLQ
PEKKPVVLKG WSDEESDVRS FLQCLPYISQ LSCDDQFFLC LCEALSVGSE WDAHLCTSLL
HAVDYTVVLS GWLPSVTCRT VGAVLGQSAS GGKLNITLTP QSMSFQGARQ LFKKVENLHK
LRVNEMAVLK LARMAKFGSC HNPVLIEEMI LDLSSPAVPE GVLRRVISSL ASLLRCWPIR
SLDLTDCQIE GYLLTSLLCH QGHLCTFRLN GESMQQLTDV VYEAQDKELT QCFLVKCGHD
LSYCTLNWDV LQYLLQSTTQ PITVNLRRSQ FKPKDIIHLL PCLTNIHFKR INSRFKRTAL
REIYKQRAGH MVTTLLKSSD EWINLNNLVL DRYDCEALRF ALHYSDGVKL NLLWTIVPKT
EMRNILGLLH RVLTLRIDRE LLLELLHACR DFGLQKTAVD LLRLLDHKLD LSCSSAMDLS
RQEEGTVLSL TTGDCMVIAS AVQVADCNTE INLHDCQVGN AGLEELIPVL HRVHLSIGKQ
ILLQFLHLIS VRDGDRSGRL ALFLSRALGK ELDLSQTPLD LVACSSLALI LEYSEGLSEL
DLHNCNLTDN HLNCLLMHLH KVQVLNLSNN EVTDQGAIYV KDKLSRNGFT GTVWLHSRKA
TKPDNVLPED KRYKVCLTYG ESKRFSKTKA HFKEFDPVMK LVEGRISYSF QFGSRGRFKC
TATGLIFGMK EPGTMEYSVE DWDMGILANT SYEPAGPLFQ LNSPEGDIYQ LQLPHCETEV
YSAEDLHVAH MCINNMEFLR PKKVTQSHVI VAICGLSRFG NVRKRPFYQN RVQVKVGLFL
EPDVTPTRQR LWVFLLPRNV PFTEVKEQHK EFVFIKTSPY CILRPKAKYS LTSDLKLGFK
VQPKKYILHF DSSNDHHATF EVFLNHDITE LHLKIQERTG LKALIRWSRL VILKTKSAKV
SVQKLTESQW IESLCSILEQ LTNKQMKKLK SLMMTTKERS HISKSTLEGL EDHCDVAQQM
VWAWGMNGSI MATREFMDKL QRQDECVMSL LQPFLDQCDP M
//
