ID   A0A3P8ZR86_ESOLU        Unreviewed;       738 AA.
AC   A0A3P8ZR86;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Collectin-12 {ECO:0000256|ARBA:ARBA00017460};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000031217.1, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000031217.1, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000031217.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_010883757.1; XM_010885455.3.
DR   RefSeq; XP_010883758.1; XM_010885456.3.
DR   AlphaFoldDB; A0A3P8ZR86; -.
DR   Ensembl; ENSELUT00000006322.2; ENSELUP00000031217.1; ENSELUG00000001430.2.
DR   GeneID; 105019342; -.
DR   KEGG; els:105019342; -.
DR   GeneTree; ENSGT00940000158238; -.
DR   OrthoDB; 4613106at2759; -.
DR   Proteomes; UP000265140; LG21.
DR   Bgee; ENSELUG00000001430; Expressed in bone element and 14 other cell types or tissues.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd03590; CLECT_DC-SIGN_like; 1.
DR   Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR018378; C-type_lectin_CS.
DR   InterPro; IPR033989; CD209-like_CTLD.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR016187; CTDL_fold.
DR   PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR   PANTHER; PTHR24023:SF1105; MULTIPLEXIN, ISOFORM R; 1.
DR   Pfam; PF01391; Collagen; 3.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; C-type lectin-like; 1.
DR   SUPFAM; SSF57997; Tropomyosin; 1.
DR   PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Collagen {ECO:0000256|ARBA:ARBA00023119};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        41..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          610..727
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000259|PROSITE:PS50041"
FT   REGION          434..584
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          72..124
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          174..250
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        559..576
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   738 AA;  80012 MW;  BEBE02729BA80791 CRC64;
     MKDDFADEEE VQSFGYKRFG IQEGTQCTKC KNEWALKTSI ALLYVLCTLL TIAVAVLGYK
     VVQKVDNVSE GIESYGGKIN AVETDLKKLD DQTGEKSENT TTEIQAFKNN IRALQRQLSE
     VAERSSSNRA ALGRLQDADQ DMQGSQASIQ VLLDANTATL RYINGTLQAY GGTLDGLQGD
     TARLQTELQE QVRKQSQALL SISNLNLTQA QQRGLISALQ RSVDDTSQAI QKIRNDFQSL
     EQTARQTKSD TDWLREKVQN LQALASNASA IAKSNNDSLE DMGSQLATLS GQLQNTSSLT
     ESHDQTLREI MDQQRDHDNL TSSKFDRLEI RLDESEGNID RVTGNISFTT QLLGTINLEL
     NELRTCTEVV GRHSDYLTDL NTTVSNVRSD ATTLRSQQDD LAARLDKEVT SLSIVMEEMK
     LVDSKHSQLI TNFTILKGPP GPRGPRGDKG PQGVAGQPGQ KGEKGEKGGP GVQGLRGEKG
     SPGPPGVPGF KGPPGSRGSP GSKGSRGSGG RAGPPGPKGE PGAAGLPGRD GQPGPHGPQG
     LPGEPGLIGP TGAQGPRGPV GPVGPPGPPG LPGLPTRPQA TEPLVPFSLH SDSPVPTVWV
     RGCAQEWVGF KGTCYYFSKE TQNFDDSKKY CNAQNASMVI IETMDEQKWL QKQTSGKGFF
     WIGLTDKEEE NVWRWLDGTE PAFTKWKPGQ PDNWTHGHES GEDCAGFIHM GMWNDFFCED
     RISYICETPM EISKTPGL
//