ID A0A3P8ZRY9_ESOLU Unreviewed; 795 AA.
AC A0A3P8ZRY9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Dipeptidyl peptidase like 10 {ECO:0008006|Google:ProtNLM};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000031199.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000031199.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000031199.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8ZRY9; -.
DR STRING; 8010.ENSELUP00000031199; -.
DR Ensembl; ENSELUT00000006376.2; ENSELUP00000031199.1; ENSELUG00000008667.2.
DR GeneTree; ENSGT00940000154657; -.
DR InParanoid; A0A3P8ZRY9; -.
DR OMA; AYDEGTN; -.
DR Proteomes; UP000265140; LG16.
DR Bgee; ENSELUG00000008667; Expressed in camera-type eye and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF207; INACTIVE DIPEPTIDYL PEPTIDASE 10-LIKE; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 131..497
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 581..780
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 795 AA; 90090 MW; 2A6E0F38DD8DD1E6 CRC64;
MNQSAGVAQT VRRHSSVDKG LPDIGPDRNW KGIAISLLVI VGVLSLIGLS IILLSKNDGS
KSLGTHLTLD DLFEREFQVH DPEAKWINDE EIIFRTWHGD VVIANTQSNE TDILLKNTTF
ATFKASKFAV SPDRNYVLLG YDVKQVYRHS FLASYLIYNL HTREVRELNP PEVFDSVLQF
ASWGVRDQQL VYVFENNIYY QTDVKSSSWR LTSSGQEGKV FNGIADWLYE EEVLHSQVGH
WWSPDGSRLA YLTLNDTLVP NMLLPRFTGS LYPRGQHYPY PKVGQVNPTA KLFVITLDGG
SQTTELEPPN SFEKSDFYIT MVKWVTEEKI AVRWLNRAQN TSILSLCEVT MGACVKKHIM
TSDKWLDRQN EEPVFSKNGN TFFFSMPIKH GGRGSFNHIA MISDQFSGNE VNMRHLTSGS
WEVSQILAYD EKVDTVYFLS TEDGSTQRQL YRVLAVDPFQ RECLTCSLFK PQCSYYNAVF
SPDYQYVLLN CKGPDIPITT LHKISDMSKN ETLEKNKVLR DALLYRNIPR KDIRILQINN
FALRLQLTLP RDFDEATEHP LLLILDSAPG DQAVSDRFVL DWDSVLVSSD NIIVARLDGR
GSGFLGQRVL HEVHQRLGTV EVQDQVAAVE ILAKLPYVDG NKVAVYGKAY GGFLSSLLLL
SFGSLFKCGV AVAPVTDWRL YGSAFTERYF GFPVKDERKY QLSSLLPNIT GTSHLKFLII
HGTADATIHF QHSAELVKLL SISNINYTLQ IFPDEGHNID AVKSRHYMLN SIMTFFRECF
LEEAPVDPSA SKEED
//
