ID A0A3P8ZS01_ESOLU Unreviewed; 816 AA.
AC A0A3P8ZS01;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Semaphorin 4D {ECO:0000313|Ensembl:ENSELUP00000031416.2};
GN Name=SEMA4D {ECO:0000313|Ensembl:ENSELUP00000031416.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000031416.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000031416.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000031416.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR RefSeq; XP_010904038.1; XM_010905736.3.
DR AlphaFoldDB; A0A3P8ZS01; -.
DR Ensembl; ENSELUT00000005832.2; ENSELUP00000031416.2; ENSELUG00000008951.2.
DR GeneID; 105031364; -.
DR GeneTree; ENSGT00940000159594; -.
DR OrthoDB; 5342713at2759; -.
DR Proteomes; UP000265140; LG14.
DR Bgee; ENSELUG00000008951; Expressed in heart and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF18; SEMAPHORIN-4D; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 45..523
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 581..650
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 681..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 816 AA; 91334 MW; EAB7E397F7F32B93 CRC64;
MNQYQLVEAM TDKGNFTVPK LLPESNMAFG VLGVFLGLLL EVSTHGPHSM PRTSWKHEEV
NLVEFAEPGI FNYSTLLLSE DKNVLYVGAR EAIFELSMTN VSVKNNKVEW QVSEADMSMC
ILKGKSKETD CLNYIRVLQV LDNNQLYVCG THAFQPVCRY LSLKGFSLEG PVEDGRGKCS
FDPAQSFTTI MVDGELYSGT SYNFLGSEPI ISKYSLSQSL LRTEYSTSWL NEPSFVFADV
IREGENSANG EDDKVYYFFT EVSVEYEFFG KLLIPRIARV CKGDLGGQRT LQKKWTSFLK
AKLVCSMPEL NFVFNVVHDV FILKTPNWRE TVIYGVFTSQ WGNVGLSAVC AYNMSSVEDV
FSKGKYMQKA TVEQSHTKWV RYNGITPTPR PGACINNHNR LQNINNSLHL PDKTLQFVKD
HPLLEDPVLP IGNGPKLITK DINYTQIAVE RVQALDNNMY DVIFTGTDKG VLHKSVLYEE
EVHTVEEIQL LHNSEPIKNL LISSQGTSFL YVGSDSGVVQ SPTAFCEKYP SCLDCILTRD
PYCAWDPNTS ACINIFHTQG PSRRNLIQNL SGDADNCPSV PGLSVENYQR VKVKPGSSVE
LPCLIRSNMA VAVWKANGSL LTEASRFHLM GETGLLIYSV APEDQGLYEC WSLEWAPAMR
KNFSRILAGY ILVLDVPRRA SPRGHPPQTA VTRTQSNPAT EGPRDLHIHW HVNGAHLEKS
VTEYRHPLQC GGTKGEVLVS SWVKEVALAK DSSYQCVAVS SAGNDTSKVD LHLISRDEDS
IPSRDMSQWR GSLSEHEKLL KRWKRAWESC DGQGAL
//
