ID A0A3P8ZSW4_ESOLU Unreviewed; 600 AA.
AC A0A3P8ZSW4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Kelch-like ECH-associated protein 1 {ECO:0000313|Ensembl:ENSELUP00000031388.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000031388.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000031388.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000031388.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8ZSW4; -.
DR STRING; 8010.ENSELUP00000031388; -.
DR Ensembl; ENSELUT00000005888.2; ENSELUP00000031388.2; ENSELUG00000008917.2.
DR GeneTree; ENSGT00940000165458; -.
DR InParanoid; A0A3P8ZSW4; -.
DR OMA; FDGENRW; -.
DR OrthoDB; 5472491at2759; -.
DR Proteomes; UP000265140; LG22.
DR Bgee; ENSELUG00000008917; Expressed in bone element and 15 other cell types or tissues.
DR GO; GO:0071379; P:cellular response to prostaglandin stimulus; IEA:Ensembl.
DR GO; GO:0071466; P:cellular response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR CDD; cd18458; BACK_KLHL19_KEAP1; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR047098; KEAP1_BACK.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412:SF35; ACTIN-BINDING PROTEIN IPP; 1.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 54..125
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
SQ SEQUENCE 600 AA; 67054 MW; 48C9A192057600DF CRC64;
MLCPRKKRLT KDADFSAFVV PSMRGSGYLD YTIESHPCRA LQAMEEFRRH EMLCDITLHV
TYKDTTTDFK VHKVVLASCS PYFKAMFTSS FKECHASEVT LRDVCPLVVE RLIDFAYTSR
ITVGETCVMH LLLSSMRYQM EDVARACCDY LTKNLEPANV IGIARFAEEI GCTELHLKSR
EYINTHFNMV TKEEEFFSLT HCQLLELISQ DSLKVLCESE VYKACTDWVR WDLESRAPYL
HALLNALHVY ALPPKFIKIQ LQSCPILSKA NSCRDFLSKI FQEMALRKPL PPVPHRGTQL
IYVAGGYRQH SLSSMEAYDP RRNVWLKLAS MDSPCSGLGS CVLFGLLYTV GGRNLSLQDN
TESSSLCCYN PMTNKWSQNA PLNSPRNRVG VAVVDGSIYA VGGSQGPTHH DTVERYDPEA
NRWVFVRPMS VARLGAGVAG CGGCVYVAGG FDGQNRWNTM ERYQPDSDTW HQLAPMSTVR
SGLGMVCVDS YLYAVGGYDG LVQLSSVERY SVARDVWEPV ASMRDRRSAH GVTTYQGRIF
ALGGFNSTGF LSGVESYCPN ANQWTAVTNM LLGRSGMGVA VTMEPCPGNL PEDDEEEEVA
//
