ID A0A3P8ZT77_ESOLU Unreviewed; 1770 AA.
AC A0A3P8ZT77;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Brefeldin A-inhibited guanine nucleotide-exchange protein 1 {ECO:0000313|Ensembl:ENSELUP00000031811.1};
GN Name=ARFGEF1 {ECO:0000313|Ensembl:ENSELUP00000031811.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000031811.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000031811.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000031811.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}.
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DR Ensembl; ENSELUT00000004829.2; ENSELUP00000031811.1; ENSELUG00000009556.2.
DR GeneTree; ENSGT00940000157108; -.
DR Proteomes; UP000265140; LG03.
DR Bgee; ENSELUG00000009556; Expressed in testis and 15 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032629; DCB_dom.
DR InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR046455; Sec7/BIG1-like_C.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF137; BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 1; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF20252; BIG2_C; 1.
DR Pfam; PF16213; DCB; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF09324; Sec7-like_HDS; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 657..846
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 204..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1770 AA; 198934 MW; 796634A33865BDFD CRC64;
MFESKTKNMF LTRALEKILV DKEVKKAHHS QLRKACEVAL GNSPSGDDQS DCCALPPIKS
KGTVIEADKY FLPFELACQS KCPRIVITSL DCLQKLIAYG HLTGNAPDNT TPGKRLIDRI
IETICGCFQG PQTDEGVQLQ IIKALLTAVT SQHIEIHEGT VLQAVRTCYN IYLASKNLIN
QTTAKATLTQ MLNVIFARME NQVNQETPAS PHQKPPASPL CRQHASSPQT PTSPHLEPCA
SPEHEQCTPS HLPRREATRV REPNALEDPE AENGSVFCSA ENDQTEADQA TAAAAKGTSL
SFSSLNSIHT ESIDDTPVPV VLEEEGGLGS DTENVHANGI PGTPISTGFT PSLTDDRLSL
SSNDTQESGA TSGSSPVAKF SHILQKDAFL VFRSLCKLSM KPLSDGPPDP KSHELRSKVL
SLQLLLSILQ NAGPIFKTNE MFINAIKQYL CVALSKNGVS SVPEVFELSL SIFLTLLSHF
KTHLKMQIEV FFKEIFLYIL ETSTSSFDHK WMVIQSLTRI CADAQSVVDI YVNYDCDLNA
ANIFERLVNY LSKIAQGRVG HELGTTPAQE LSLRKKGLEC LVSILKCMVE WSNDQYVNPN
SQTSLGQEKP VEQDPSESTK TPETINRYGS LNSLDSTASS GIGSYSTLMS GTDNAEQFEV
LKQQKEIIEQ GIDLFNKKPK RGIQYLQEQG MLGTTPEDLA QFLHQEERLD STQVGEFIGD
NERLNKEVMY AYVDQMDFQG KDFVSALRLF LEGFRLPGEA QKIDRLMEKF AARYLECNQG
QTEFASADTA YVLAYSIIML TTDLHSPQVK NKMTKEQYIK MNRGINDSKD LPEEYLSAIY
DEIAGKKIAM NETKKLTLKS NKQSVASEKQ RRLLYNVEME QMAKTAKALM EAVSHVQAPF
TSATHLDHVR PMFKLAWTPF LAAFSVGLQD CDDTEVASLC LEGIRCAIRI ACIFTIQLER
DAYVQALARF TLLTASSGIS EMKQKNINTI KTLITVAHTD GNYLGNSWHE ILKCISQLEL
AQLIGTGVKA RYISGTVPAR GGLLASLREQ ASDSSEYLGL VGGNVDRKQI ACIQESIGET
SSQSVVVAVD RIFTGSTRLD GNAIVDFVRW LCAVSMDELG SPTHPRMFSL QKIVEISYYN
MGRIRLQWSR IWEVIGDHFN KVGCNSNEDV AIFAVDSLRQ LSMKFLEKGE LANFRFQKDF
LRPFEHIMKK NRSPTIRDMV VRCIAQMVNS QAGNIRSGWK NIFSVFHLAA SDQDESIVEL
AFQTTGYIVT NVFEKHFPAT IDSFQDAVKC LSEFACNASF PDTSMESIRL IRHCAKYVSE
RPQAFKDYTS DDMNVAPEDR VWVRGWFPIL FELSCVINRC KLDVRTRGLT VMFEIMKTYG
HTYKKHWWQD LFRIIFRIFD NMKLPEQQTE KAEWMTTTCN HALYAICDVF TQYFESLSDI
LLDDILSQLY WCVQQDNEQL ARSGTNCLEN VVILNGEKFS PETWDKTCNC MLDIFKTTIP
HAWKVTHSSS GVSLHPSHIV LLSHSACPAS VAVFAEVQEQ RLFSALRIKC VVQLELIQTI
DNIVFFPATS RKEDLVLRCM VLNRNKGMYR YLTSEQLFKL LDCLLESHHF AKAFNSNNEQ
RTILWKAGFK GKSKPNLLKQ ETNSLACGLR ILFRMYTDNS RKAAWEEAQR RLLNVCGEAL
AYFLTLTSES HREAWTNLLL LFLTKVVKIS DDRFKAHASR YYPLLCDIMQ FDLIPELRVA
LRKFLLRIGN AFDISLLTSP REELGPAGSQ
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