ID A0A3P8ZU52_ESOLU Unreviewed; 1846 AA.
AC A0A3P8ZU52;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Plexin-A2 {ECO:0000313|Ensembl:ENSELUP00000031828.1};
GN Name=PLXNA2 {ECO:0000313|Ensembl:ENSELUP00000031828.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000031828.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000031828.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000031828.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR Ensembl; ENSELUT00000004825.2; ENSELUP00000031828.1; ENSELUG00000001371.2.
DR GeneTree; ENSGT01050000244850; -.
DR Proteomes; UP000265140; LG17.
DR Bgee; ENSELUG00000001371; Expressed in brain and 4 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF37; PLEXIN-A2; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 3.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 4.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 4.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 2.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1189..1211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..394
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
SQ SEQUENCE 1846 AA; 206280 MW; 3DC264FE56192BD9 CRC64;
MGMETRLDIG QTYCSGTKGQ TWSLTWWRLV LMSMSLVMDR GQSLSTFQSE RTEWTLNHLS
VHKTTGVLYV GAVNRIYKLS ANLTLLVSHN TGPEHDNKAC YPPLIVQPCS EPLASTDNVN
KLLLIDYSHN RLLACGSLYQ GVCKLMRQDD LFILVEPTHK KEHYLSSVNQ TGTMYGVIVP
LSQGQDGTLF IGTAVGGKQD YFPTISSRKL PRDPESSAML DYELHTDFVS SLIKIPSDTL
ALVPRFDIYY IYGFASGNFV YFLTVQPEVP ENGMPAGGSP GDLFYTTRII RLCKGDKKFH
SYVSLPVGCL HKGEEYRLLQ AAHLSKAGKV LARSLNISAQ DDVLFTVFTK GQKQYLEPLD
SSALCVFTIR DINARIKERL QSCYQGEGNL ELHWLLGKDV QCTKAIRVDG PPEGGVLYET
LTVMTDGRPI LQDMAFSLDY NSLYVMSDSQ VTKVPVEACE QYGTCGECLS SGDPHCGWCV
LINMCARRGR CERAEEPFRF ATNNERCVKV ISHPDSIAVS AHSVPLLLEV RNVPDLSAGV
TCSFGAEMEV EGRVNGNRVM CLSPSGKEVP HIPEGQDWLG VELRLNSKET GQMLGSTEVK
FYNCSMHQTC LSCVNSTFLC HWCKYRSLCT HDPSSCSFQE GRVNNSEDCP QLVRSGEILF
PAGEVRPITL RARNLPQPQS GQRGYECVLH IQGTNHRVTA LRFNSSSVQC QNSSYIYEGV
KISDLAVDLS IVWNGNFIID NPEKIKVNLY KCGAQRDSCG MCLRADRKFQ CGWCSGEGRC
TMRQHCPSIS PYTNRWLHLS TRNVKCTDPR ITEVTPLAGP PEGGTLVTIR GQNLGLSFSE
LVGNLEVAGV QCSPQEDGYI TAEQIVCEMG STPQGSSPGL VQLCVGECRP ELRTRSSQLY
SFVNPTMVEL TPVRGPESGG TKVTIMGVNL GAGSSVNVTF GNQTCELYRR TMAEIVCFSA
PSVTGAGQVL VSLSVDWAKV PGSLSFQYIE DPTVQRIEPE WSITSGHTAL TVTGTNLDVV
QEPRIRVKYA GHESINVCKV LNTTTIICFA PSLKAESTPE HESVKHVEEF GFVFNNVQGL
LNYNNTNFIY YPDPYLEPLS LSGVLEQKPG SPIILKGRNL VPSASGGARL SYTVLIGETA
CSLTVSDTQL LCEPPNLTGQ HRVLVHVGGL HMSPGTVHIR SESLLTLPAI ISITAGGGLL
LIIVFIVLVA YRRKSHENDL TLKRLQMQMD NLESRVALEC KEAFAELQTD INELTSDLDR
AGIPHLDYRT YTMRVLFPGI DDHPVLRELE VSGCGQQDVE KALKQFAQLV NNKVFLLTFI
RTLELQRSFS MRDRGYVASL IMTALQGRLE YATDVLKHLL SDLIERNLES KNHPKLLLRR
TESVAEKMLT NWFAFLLHKF LKECAGEPLF MLYCAIKQQM EKGPIDSITG EARYSLSEDK
LIRQQTEYKT LTLCCVNPDN ENSPEIPVKV LNCDTINQVK EKILDAVCRN MHFSQRPRAA
EMDLEWRQGR TARVVLQDED ITTKIEGDWK RLNTLMHYQV SDRCVVALVP RQLSSYSLPS
SASFPRSVSR YDLPFRTSTT TSPDSPHSRV PMITPDMESG VKVWHLVKNH DHGDQKEGER
GSKMVSEIYL TRLLATKGTL QKFVDDLFET LFSTVCRGSA LPLAIKYMFD FLDEQADKHG
IHDMDVRHTW KSNCLPLRFW VNVIKNPQFV FDIHKSSITD ACLSVVAQTF MDSCSTSEHR
LGKDSPSTKL LYAKDIPHYK SWVERYYADI KRLPAISDQD MNAYLAEQAR LHSNEFNVLS
ALHEIYTYVS KYSQEIMEAL EQDEQGQKQR LSYKVEQIIA AMSVES
//
