ID A0A3P8ZUM6_ESOLU Unreviewed; 664 AA.
AC A0A3P8ZUM6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Forkhead box protein K1 {ECO:0000313|Ensembl:ENSELUP00000032442.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000032442.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000032442.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000032442.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR AlphaFoldDB; A0A3P8ZUM6; -.
DR Ensembl; ENSELUT00000003200.2; ENSELUP00000032442.2; ENSELUG00000010530.2.
DR GeneTree; ENSGT00940000159507; -.
DR InParanoid; A0A3P8ZUM6; -.
DR OMA; QTHDPRK; -.
DR Proteomes; UP000265140; LG09.
DR Bgee; ENSELUG00000010530; Expressed in bone element and 15 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd20054; FH_FOXK1; 1.
DR CDD; cd22688; FHA_FOXK; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047394; FH_FOXK1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45881; CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR45881:SF4; FORKHEAD BOX PROTEIN K1; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 79..132
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 278..373
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 278..373
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 203..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 664 AA; 71515 MW; 2FFD24D9BCFE5210 CRC64;
MADFRDDTGA RALLALQSAP CSPVRVGVTS HPYPPSLALS GSAVLGRGCG ISPRLASPPR
ALARLEGRDF EFVMRQRTVT VGRNSSHGSV DINMGHSSFI SRRHLQITFE EPCGFSLRCL
GKNGVFVDGV FQRRGAPPLQ LPRECVLRFP STVIKIQFSS LLSEEELREE EQLSPPPRLP
LLPHISPLKI SIPTMHQDDL RHMVSPLPSP TGTLSVPNSC PASPRGAGSS GYRYGRNVTS
DLQLAAEFAA KAVSEQQRGV AEQLGESGDG DSPKDDSKPP YSYAQLIVQA ISSAPDRQLT
LSGIYTHITK HYPYYRTADK GWQNSIRHNL SLNRYFLKVA RSQEEPGKGS FWRVDSASEG
KLVEQAFRKR RQRGVACFRT PFGPLSSRSA PASPTHQGLL SPPSSGLQTP ECLSREGSPL
SHEPPHHHHD LAHKLASVPE YRYTQSAPGS PVHSQPVIMA APPHPLPTGL GKPLALFSGP
GGSQTLHMLQ SPPTTLTMLR LVTTATSSNP TNGYILTPGG GAQGHITTRQ DSEHRDLQQQ
TRERVIQSVE GAQQGLEGRG LSLGLHQLPV RPVTQNGKHA SAVATVTSVA SAYALTSPLQ
ILAAQASSSP PVLLSRQPNA GPDVGPEAPG EPQAKRPKIE EDEAPPSQQP VIVAMSSQPH
DNRK
//
