ID A0A3P8ZVE8_ESOLU Unreviewed; 1590 AA.
AC A0A3P8ZVE8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=SH3 and multiple ankyrin repeat domains 3b {ECO:0000313|Ensembl:ENSELUP00000032860.2};
GN Name=SHANK3 {ECO:0000313|Ensembl:ENSELUP00000032860.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000032860.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000032860.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000032860.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Postsynaptic density
CC {ECO:0000256|ARBA:ARBA00034105}.
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DR STRING; 8010.ENSELUP00000032860; -.
DR Ensembl; ENSELUT00000002155.2; ENSELUP00000032860.2; ENSELUG00000010954.2.
DR GeneTree; ENSGT00940000153561; -.
DR Proteomes; UP000265140; LG14.
DR Bgee; ENSELUG00000010954; Expressed in heart and 11 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd09506; SAM_Shank1_2_3; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24135; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24135:SF29; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 3 ISOFORM X2; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00248; ANK; 7.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT REPEAT 179..211
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 246..278
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 279..311
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 448..507
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 548..642
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1527..1590
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 342..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1003..1025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1038..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1117..1458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1485..1506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..829
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..866
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..902
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1060
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1131..1149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1200
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1240..1264
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1265..1281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1425..1439
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1590 AA; 173978 MW; B0A119FCA9C2D956 CRC64;
RLTRLLKPVS VRFSFPLDKC LRLDPEAAVW SSKQRVLVTL TQSLTDVLNY GLFQPAFNGR
AGKFLDEERL LKDYPLPPIT PIPYLEFRYK RRVYTQSYVD DKQLAKLHTK ANLKRFMEYV
HQRSIDKVSR FLEKGLDPNF HDADTGECPL TLAVQLEGSA ELIKVLRSGG AHLDFRTRDG
ITALHRAVLC RNHAALTTVL DLGASPDYKD SRGLTPLYHS AIVGGDPYCC ELLLHEHAVI
GSTDENGWQE IHQACRHGNV QHLEHLLFYG ADMSAQNASG NTALHLCALY NQEGCARVLL
FRGANKDIKN YNNQTAFQVA IIAGNFDLAE IIKIHKTSDV VPFRESPSYS SKRRRLGGAS
HVSGSGLSSP RSLIRSASDN ALESPASSSP GPSLHSLENT PSRQADTHSL RRETRRLSPS
GRLQRDPSPP PSPPSPVQRG KRRLYSAVPG RTFIATRSHT PQGPGEISLH RGERVKVLSI
GEGGFWEGSV KGRTGWFPAD CVEEVQMRQY DPRLETREDR TKRLFRHYTV GSYDNYSSYS
DYVIEEKSAV LQKRDSEGFG FVLRGAKAET PIEEFAPTPA FPALQYLESV DLEGVAWRAG
LRTGDFLIEV NGSDVVKVGH RQVVSLIRQG GSQLLMKVVS VTRKPESDLV RKKAPPPPKR
APSTSLTLRS KSMTAELEEI ASARRRRVEK LDEMLIGTQE VVMRKRPSEA DYRAATVKQR
PTSRRITQQE INSLFERQGL PVPQGVSFGL EKATMQLPRG MSRTKSFGAP EDDRISALIG
EHRFPRSSSM TDSFIPPPPQ TAPPPPPSHY YLDSGPPPAF CPPPPPQRAT DQSRSSFKPG
AEPRLHDVCD SSASRSHAER QRKARSMIIL QDSAVTGHQP ADPTPSPSPL SRTSPIPSPN
PSGEQNPYAN VGQLPAPPSK PQRRKSPLLK QVQVEEGPSR AELYQQQVLT ERAQIRVTPP
QGRRSSFFLS VEGGGSEAPP ILLTQSHSVD DLGELPPPIP VLSPSSSPHS TFLHPLTGKP
LDPSSPLALA LAARERALTA RTPSPEPRPK HTHSPSPEPR PKHTHSPSGV TSPAGPSPER
WQAMPLPAIS QVTINVTNDN QPAGRGLGEE LIEALHGQLQ RRRSLTVGSS EEEGGPYTQT
QTQSERRKSL DGGPYTVTLP PALLSSSDEE TREELRKIGL VSPPLAFVTP PSPTQPPSSL
SLSPRRPQAG EGVGGCESAP DSGVEEGDPH IESTSSPSST PAPSLPPTLP SPEHPQPRPS
TPTTPTTPTS TASSTQEPQA LKPRLRSPLG RGRSALRDPL LKQSSDSELL PSGSGPGRPP
RYLFQRRSKL WGEVTESRPR QSSPEEGRPA AVGGGGLELA TRLQLLSKDS HSLGEEPAAL
LDPGRRSPVG GARLFSSLGD VHTISQRGFG GTTYTVRPGC RYPITPRRSP SPSPSTGPVP
SPERSEVSPG RSFGFSSSHH HHTILKSSSL SLPSEPKEVR FVMRSASART RSRSPSPSPH
ASPCPSPVLG SPLLALRPWR QRPLALWSKY DVGDWLESVG LAEHRTRFQE HEIEGSHLPA
LTKDDFAELG VTRVGHRMNI ERALRQLLDN
//
