ID A0A3P8ZW58_ESOLU Unreviewed; 430 AA.
AC A0A3P8ZW58;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Saccharopine dehydrogenase-like oxidoreductase {ECO:0000256|ARBA:ARBA00039852};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000032841.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000032841.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000032841.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00038048}.
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DR AlphaFoldDB; A0A3P8ZW58; -.
DR Ensembl; ENSELUT00000002204.2; ENSELUP00000032841.2; ENSELUG00000000398.2.
DR GeneTree; ENSGT00390000004799; -.
DR InParanoid; A0A3P8ZW58; -.
DR OMA; TMQLRYN; -.
DR Proteomes; UP000265140; LG18.
DR Bgee; ENSELUG00000000398; Expressed in ovary and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR PANTHER; PTHR12286:SF5; SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE; 1.
DR PANTHER; PTHR12286; UNCHARACTERIZED; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 277..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..150
FT /note="Saccharopine dehydrogenase NADP binding"
FT /evidence="ECO:0000259|Pfam:PF03435"
SQ SEQUENCE 430 AA; 47106 MW; 4608E9766EE16BCF CRC64;
MATVISNRPY HIIVFGASGF TGQFVVEEVA RNAKEGPSGS MKWALAGRSR HRLEGVLEQA
ADSLNKPELR IEVDIIVADV SDADSLAIMC QQGLVVLNCV GPYRFYGEPV VKACIENGAH
CIDICGEPQF LEGMQLEYHS KAMVSGVYVI GSCGFDSIPA DMGILYTKDH FKGTLTAVES
FLTIHTGPEG GCAHDSTWQS AIYGFADSGS LRKLRKKFGH QPLPVVGAPF KKRYGGCLFF
SKEINQYAIP FMGSDRSVVK RSQRFLYEDQ KATPVQYTAY VGVGGVWSLI KLFCGGLIFW
FLGKFRLGRK LLITVCILNV YPVYSLSHLP LILQMEGTSF RLTFFGEGYA EGTEPSQGRP
NARICTQIHG AEPGYVATSV TMVQAAITVL NEPQFLPVKG GVYSPGAVFA KTTLIHRLNK
HGLVFSVLRF
//
