ID   A0A3P8ZW76_ESOLU        Unreviewed;       380 AA.
AC   A0A3P8ZW76;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Forkhead box F1 {ECO:0000313|Ensembl:ENSELUP00000032563.1};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000032563.1, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000032563.1, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000032563.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR   RefSeq; XP_010877622.1; XM_010879320.2.
DR   AlphaFoldDB; A0A3P8ZW76; -.
DR   STRING; 8010.ENSELUP00000032563; -.
DR   Ensembl; ENSELUT00000002914.2; ENSELUP00000032563.1; ENSELUG00000010487.2.
DR   GeneID; 105015863; -.
DR   KEGG; els:105015863; -.
DR   GeneTree; ENSGT00940000161035; -.
DR   InParanoid; A0A3P8ZW76; -.
DR   OMA; SGVMEPH; -.
DR   OrthoDB; 5385885at2759; -.
DR   Proteomes; UP000265140; LG02.
DR   Bgee; ENSELUG00000010487; Expressed in stomach and 12 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
DR   CDD; cd20049; FH_FOXF1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR46262; FORKHEAD BOX PROTEIN BINIOU; 1.
DR   PANTHER; PTHR46262:SF1; FORKHEAD BOX PROTEIN F1; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT   DOMAIN          53..147
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DNA_BIND        53..147
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          234..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          278..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        234..253
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        278..295
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   380 AA;  41508 MW;  711D957B528A7EF5 CRC64;
     MTAEVQQPPA QTPAQSSPMS APEKPHGQTT VMETASSTTK TKKTNAGIRR PEKPPYSYIA
     LIVMAIQSSP TKRLTLSEIY QFLQSRFPFF RGSYQGWKNS VRHNLSLNEC FIKLPKGLGR
     PGKGHYWTID PASEFMFEEG SFRRRPRGFR RKCQALKPMY SMMNGLGFNH LPESYNFQGS
     GGGLSCPPNG LSLDSGIGMM NGHLAGNMEG MGLSGHSMSH LSANSGHSYM GSCTGSTGSE
     YPHHDNSGSP LLTSGGVMEP HPVYSSSASA WAQAPSSSLN NGGSYIKQQP LSPCNPGANP
     LQPSLPTHSL DQYNLHQNAH SNTDLQGIPR YHSQSPSMCD RKEFVFSFNA MTSSTMHSPS
     SSSYYHHQQV AYQDIKPCVM
//