ID A0A3P8ZW83_ESOLU Unreviewed; 269 AA.
AC A0A3P8ZW83;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=COP9 signalosome complex subunit 7b {ECO:0000313|Ensembl:ENSELUP00000032866.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000032866.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000032866.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000032866.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC involved in various cellular and developmental processes. The CSN
CC complex is an essential regulator of the ubiquitin (Ubl) conjugation
CC pathway by mediating the deneddylation of the cullin subunits of SCF-
CC type E3 ligase complexes, leading to decrease the Ubl ligase activity
CC of SCF-type complexes such as SCF, CSA or DDB2. The complex is also
CC involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA,
CC ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD
CC kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and
CC protects degradation by the Ubl system, respectively.
CC {ECO:0000256|ARBA:ARBA00025037}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
CC {ECO:0000256|ARBA:ARBA00008482}.
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DR RefSeq; XP_010886772.1; XM_010888470.2.
DR RefSeq; XP_010886781.1; XM_010888479.2.
DR RefSeq; XP_012986746.1; XM_013131292.2.
DR AlphaFoldDB; A0A3P8ZW83; -.
DR STRING; 8010.ENSELUP00000032866; -.
DR Ensembl; ENSELUT00000002130.2; ENSELUP00000032866.1; ENSELUG00000010923.2.
DR GeneID; 105021031; -.
DR KEGG; els:105021031; -.
DR GeneTree; ENSGT00940000157155; -.
DR InParanoid; A0A3P8ZW83; -.
DR OMA; GTYKQFR; -.
DR OrthoDB; 931897at2759; -.
DR Proteomes; UP000265140; LG03.
DR Bgee; ENSELUG00000010923; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0008180; C:COP9 signalosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0010387; P:COP9 signalosome assembly; IEA:InterPro.
DR InterPro; IPR045237; COPS7/eIF3m.
DR InterPro; IPR041481; CSN7_helixI.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR15350:SF5; COP9 SIGNALOSOME COMPLEX SUBUNIT 7; 1.
DR PANTHER; PTHR15350; COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17; 1.
DR Pfam; PF18392; CSN7a_helixI; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 1..158
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
SQ SEQUENCE 269 AA; 29839 MW; 442C63A5806797AB CRC64;
MAGEANHSNQ LEQFMLLAKK AKGPALIALI NQLLEAPGVY VFGEFLELPC IQELLKGPNE
GYTQLLKMFA YGTYHDYKVF KDTLPPLTET QKNKLRHLTI VNLAANMQVI PYAWLLRDLE
VGSVRQLEDL VIEAVYANVI RCKLDQSQLQ LEVDACLGRD VRSEGMGCIA SVLAQWCSGC
ESVSASVEQE VGRVGQSRGS HLRALQQIEA EVANISRMIS ARDISERYQE MDPLGVGEQE
GEGSVAGAES RQTPLKMVSE LKTFTNQRH
//
