ID A0A3P8ZX95_ESOLU Unreviewed; 1606 AA.
AC A0A3P8ZX95;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Multiple EGF like domains 6 {ECO:0000313|Ensembl:ENSELUP00000033104.2};
GN Name=MEGF6 {ECO:0000313|Ensembl:ENSELUP00000033104.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000033104.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000033104.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000033104.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSELUT00000001520.2; ENSELUP00000033104.2; ENSELUG00000011373.2.
DR GeneTree; ENSGT00940000156971; -.
DR Proteomes; UP000265140; LG17.
DR Bgee; ENSELUG00000011373; Expressed in liver and 8 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR Gene3D; 2.10.25.10; Laminin; 11.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 7.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24035; MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN; 1.
DR Pfam; PF07645; EGF_CA; 4.
DR Pfam; PF14670; FXa_inhibition; 4.
DR Pfam; PF00053; Laminin_EGF; 10.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 32.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM00180; EGF_Lam; 20.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 19.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 13.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..127
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 126..164
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 207..247
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 459..499
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 563..599
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 861..892
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 905..935
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 987..1022
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1030..1065
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1073..1108
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1121..1151
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1159..1194
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1337..1367
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1418..1453
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 135..152
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 154..163
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 589..598
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 882..891
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 925..934
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1012..1021
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1055..1064
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1098..1107
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1141..1150
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1184..1193
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1357..1366
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1443..1452
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1606 AA; 172000 MW; 274511B84240B0B5 CRC64;
MLFNAYAKYC YVYQKVKMDF IFVSILVIFI DGIYALSRYG NLQPYMPNVC AEREVTLVAQ
RQPCVQAFTR MVKAWKQGCS GQNWCMGYER RTAYYTAYRQ VYKQDYQNVY KCCPGWSQLN
GEAGCLYPVC SYGVCFNGGQ CREGSRSSSQ LCDCPAGFNG PSCQYDVNEC EETNGGCEAL
CCNTIGSFYC RCPSGEQLKE DSRTCQDIDE CQVHNGGCQH KCVNTRGSYH CECNPGSRIH
VDGRTCIAVQ SCSISNGGCE HFCVQQSPAA FRCHCRTNYV LSEDGKHCKL KNPCFDKNGG
CQHLCHAEGG MPICDCRNGY KLAEDRRTCE DIDECQSGQT GCAHGCHNTV GSFSCVCHAA
YELGADGLQC YRIEMEIVNS CEGNNGGCSH HCQHSTRGPV CSCNQGHQLE DDLKTCVDLD
ECVEGSSCCQ QECTNYPGGY ECYCAAGYRL NPDGCGCDDA DECLAANGGC DHTCQNTAGS
FQCFCHQGFR LDEDRRSCEP LENTVEALSG GGREAVGPQP QLTLLQEYSQ ALERFDDYED
DDAGELLAES NLAEKFVCLN NTFGHDCSLT CEDCANGGLC GPGRDRCLCP NGWTGLICNQ
TCPEGSFGRN CSFPCKCKNG AICDPVNGNC RCPPGVSGDM CQDGCPKGFY GKLCNKRCNC
ANNGRCHRTY GACLCDPGLY GRFCHLPCPK WAFGPGCSEE CQCVQQNTLE CHRRHGTCIC
KPGWQGKACR EECDPGSFGT GCESKCECPP GVSCDHVTGQ CQKLCPAGRR GNNCDQGRLS
FWCKGIYLWD CVWLPLVRLS LSVSRPPDCP DGRFGPGCAQ ACDCSGAPCD RVSGQCQCPA
GTSGQRCEDV CLEGLWGVGC REVCPACENG GVCDKHNGTC SCPAGFTGHL CNSSCPTGRF
GLGCHLHCVC ENRGHCHHVN GHCTCAPGWT GPSCRKACDT GHWGRDCAEK CNCKNGDGSC
DAETGQCNCE AGYTGKRCHE KCPEGSHGLG CRHLCQCDNN GSCDHVSGAC TCLAGWTGTF
CEKSCPQGFY GLDCQRKCVC LNGGHCNHVT GVCVCPDGWM GHACNLTCPA GFYGESCNQT
CVCQNNGSCH PASGLCVCSP GWTGPSCSQR CPVGFYGPGC LQHCLCQNGA TCDRITGQCT
CANGWMGAAC ELECVAGRFG ADCQQRCQCE NGGQCDRRTG QCHCGPGWAG EHCERACGSG
VFGAGCAERC QCDHDAPCDH VTGQCLCPPG WRGTHCDKPC LPGTHGRACL QRCSCPRETS
CHHVSGQCGC PPGLTGNGCE LTCLPGTYGL NCNQVCQCSE TNQLCHPVTG LCYCAPGFQG
PQCNQECQDG WYGPSCRLEC QCQNSGKCRS TTGVCECTAG FIGAHCNITC PAGRYGKDCS
QVALCGEGAQ NDPVTGRCLC RPGRRGEDCG KDCAPGWFGG DCSQRCDCRN GGLCDSAAGN
CTCGLGWTGP HCETGCPPGR FGAGCQLTCA CLNNGTCDRA TGSCQCGPGH YGHQCQHACH
QGTFGVNCAK TCDCEEGTPC DPVTGRCLCT SGKTGPSCDV DCKAHRYGPD CTETCLCENG
AHCDHRNGRC TCLTSWMGVT CQEGGPPHLP YRTRRADVNS HLHNTL
//
