ID A0A3P8ZXC8_ESOLU Unreviewed; 2159 AA.
AC A0A3P8ZXC8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Uncharacterized LOC105006025 {ECO:0000313|Ensembl:ENSELUP00000032983.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000032983.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000032983.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000032983.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_019899166.1; XM_020043607.1.
DR STRING; 8010.ENSELUP00000032983; -.
DR Ensembl; ENSELUT00000001819.2; ENSELUP00000032983.1; ENSELUG00000000391.2.
DR GeneID; 105006025; -.
DR KEGG; els:105006025; -.
DR GeneTree; ENSGT00950000183035; -.
DR InParanoid; A0A3P8ZXC8; -.
DR OMA; EFSCRSQ; -.
DR OrthoDB; 2878981at2759; -.
DR Proteomes; UP000265140; LG25.
DR Bgee; ENSELUG00000000391; Expressed in camera-type eye and 5 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13183; FERM_C_FRMPD1_FRMPD3_FRMPD4; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR041779; FRMPD1/3/4_FERM_C.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46221:SF2; FERM AND PDZ DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46221; FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 61..139
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 184..497
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 28..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 920..1309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1323..1345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1505..1563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1740..1761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..656
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 959..988
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1067
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1094..1114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1293..1309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1505..1527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1548..1562
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2159 AA; 233924 MW; 3E6EB11031F1FB72 CRC64;
MEERDRSRSP SRRTSRVEQV VGRWLRRSRE SSSRERILVD GKTAAGESSG QDQKNCPVRL
TVQISRDQQL NSHGLTLSPQ TPVLVQDVTP EGPADGRLVP GDQVVKINNV AVEDLTPEQA
ADLIRECPDC VTITVLRNSV GPKSSFITPE KRAKLRSNPV KVHFAEEVEV NGHSQGNSLL
FLPNVLKVYL ENGQTKAFKF EPNTTVKDIV MTLKEKLSLC RIEHFSLVLE QKYSIAKLLL
LHEEERIQQV VQKKEVHDYR CLFRVCFMPR EPQHLLQNDP TAFEYLYLQG INDVLQERFA
VEMRCNTALR LAALHIQERL ASCGQSPKTN LKIITKSWGI ENFVSSTLLR NMREKDLRKA
IGYHMKKSQS QEPKQKVLSA NQARINYLQE LCELKSFGGK SFSATMMLQD RESMVTLLVG
SRYGISQVVN HKLSIMSTLT EFSSITRIEL LPESDRVSLV KIYLQDIKPI TLMLESVAAK
ELSCLIAGYC RALVDPSLVI FPWVQNAKQH RVSTEEGYVS RCGSDSDDSS DIDTLISLVS
HNSKRTSSDP VGLRRIMEER KEERKERKER EEKKRRENER KEKGEGEQEK HVKYRTMSPP
RKKRENERIE KSEVGGVDQR QKNRGTLEDN RERENANEEA TGQEENKGGV GEREEEDLGG
TTEELPSLSE TSDSCRTDSR FMTSVSSDSL DALEEDDLIA CSSSLPHSHT HPPFRLTVQP
PHPQPQPRRG ASSTQEAGGR RGGEGFGAGY RSGSGGGTSP DPLLSPVNPD PVNTEPLTPV
VDPSENMNYA ELSLMLEYLP SPPEASDDED DEDEERRKRE GVNSGSGRPR SSSSSSRLDC
VFTFDQSDTR CYYNICTSVT PDSAHTPNLS PPHANTEAAE VVGAEGEPRA VLNLEPVPIL
QPPPGFGDSS SDEEFFDARD RFASPEDPTS GAVPRDFSAE MTSGLMERTV SPSDVRVSLA
EGEGEDEKEG KDGDVSEGGR GGRDMFSRLS RKRSKKRRSF METDFTSTVS YPGPDQNQGW
KVDQYPDQFQ SWMESPDDTQ LLSLDPQSSE QSGNPCLTVS SLSHAEGEAC QLESKPILPK
PSQDGPGDPR APGNPEAELR RSSRSRRQSM ETEPDVMESK SVTALVTAAS HAITAVRRRV
GPDGKESTDR RGDGEEGEAE GEEKVGEGER GGVGTGPFTS HMFLTETKHV EGDRVEKTKG
EGGEKLPSPI SEGPPTGNRS RFNRRPLCIT KEEEGKASFV PQICVSPPGV YGRDIGPEDN
VTLTPPSSLL PSPPAPSIPH MVRGEGSSEN GDSGPRPKPS PTSDPENHYS CLTQAHRKLT
ISHEDLTGVG KDIEPNATSG KDSVTDNSYV ATPNICDVMA NNKATVSTDC LLATANRKDP
TSVQSVTANT IANTNMDVVT ANLDLAAANN DTNASVYSTM ANSDVSTSVY SAMANSDANA
SINSAIPSVH ITGTSVLANI PKESPASPTT GVLQSCSPGI IGQSLSASTL RGKIQSLPLF
LSRSQERALS SRSPSPKPTS DKAALNGTTK IETARKDDVT VEDSNDSLEA PAESEESEVT
PTELELGDVV VETAGAEITR LRVSEVKEVV EKVVMVYGSS PPPSTSVCLD SEPDPKMAAN
LPSRPIPEAE TTPPMASAPL CLGPASDHEP LSTGSIGPKM ALPLPSCPSA PPCPSGPPCS
SAPPCPSAPP CSSAPPCPSA PVPIRVGPKP DQEPLSLGYK MTNLSSSCPS ALVRTTHSLD
PLTVTSGPTI STEPKQDPHP EPLTPVPKMS TMLPSCSSAL VVTTQSLNGP RLSFPGRNIV
GQSFEGNRPP GEEPGLLNSL TTGCGVFTAT AHEARSELAP TQLGSSPPAK PDFGCTSVLA
SGCKEVLEGV QTPLEVCGCP PPLVYTNCFS GGDSFDDELT VYEFSCRASS PPASQTSSSA
LALPLMTSPP LSSFLPSSPP SSFLSPSFPC SVLPPFSSPE LSPLLSPLLS PSDCFLSQSR
LQDDIGRLRH RRYPAPPTGF QAIRSDVDEL LTLLQEGRLG GRGGRHPRET CATHFTENKR
LLHGEARRLM AGCQKVVRVG QTPDEMLLSL ADSFRTLVGM AGVCLWFSGC DRCDRRNADA
LAGLADVART YREFAVAAER ASGRRSCHDL STKLLAKQCT ALTASVFCLT QLFRTLTAL
//
