ID A0A3P9A0J0_ESOLU Unreviewed; 2830 AA.
AC A0A3P9A0J0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Protein eyes shut homolog {ECO:0008006|Google:ProtNLM};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000034331.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000034331.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000034331.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 8010.ENSELUP00000034331; -.
DR Ensembl; ENSELUT00000038192.2; ENSELUP00000034331.2; ENSELUG00000012900.2.
DR GeneTree; ENSGT00940000160615; -.
DR InParanoid; A0A3P9A0J0; -.
DR OMA; FYCEIAL; -.
DR Proteomes; UP000265140; LG05.
DR Bgee; ENSELUG00000012900; Expressed in ovary and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 24.
DR CDD; cd00110; LamG; 5.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.10.25.10; Laminin; 37.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24033:SF235; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00008; EGF; 19.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF12661; hEGF; 5.
DR Pfam; PF02210; Laminin_G_2; 5.
DR SMART; SM00181; EGF; 38.
DR SMART; SM00179; EGF_CA; 32.
DR SMART; SM00282; LamG; 5.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 23.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 17.
DR PROSITE; PS00022; EGF_1; 37.
DR PROSITE; PS01186; EGF_2; 25.
DR PROSITE; PS50026; EGF_3; 38.
DR PROSITE; PS01187; EGF_CA; 8.
DR PROSITE; PS50025; LAM_G_DOMAIN; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..2830
FT /note="Protein eyes shut homolog"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5027783400"
FT DOMAIN 180..223
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 224..265
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 304..342
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 369..405
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 407..445
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 447..490
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 492..528
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 562..599
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 601..637
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 639..675
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 677..713
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 715..751
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 753..791
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 793..829
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 831..867
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 869..905
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 907..943
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 945..981
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 982..1024
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1026..1061
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1063..1099
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1101..1137
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1139..1177
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1179..1218
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1242..1278
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1280..1316
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1318..1353
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1355..1391
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1393..1435
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1437..1473
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1475..1512
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1581..1761
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1784..1825
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1830..2023
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2019..2055
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2056..2092
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2103..2293
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2294..2330
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2332..2373
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2380..2564
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2560..2600
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2601..2639
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2646..2830
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DISULFID 213..222
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 255..264
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 332..341
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 395..404
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 435..444
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 480..489
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 518..527
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 589..598
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 627..636
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 665..674
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 703..712
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 741..750
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 762..779
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 781..790
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 819..828
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 857..866
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 895..904
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 933..942
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 971..980
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1014..1023
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1030..1040
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1051..1060
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1089..1098
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1127..1136
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1148..1165
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1167..1176
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1268..1277
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1306..1315
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1322..1332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1343..1352
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1381..1390
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1425..1434
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1463..1472
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1479..1489
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1502..1511
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1815..1824
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2045..2054
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2082..2091
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2320..2329
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2363..2372
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2590..2599
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2610..2627
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2629..2638
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2830 AA; 308094 MW; F3EE351C934AFC3C CRC64;
MKNMKGLSFH LVALIIAHLN GSVVIRSQSV CSRATSPQWR LQPQTVQVRW TLMENTCNST
VQCWGDEERA GTPPSHFWPV TDLPQICPLE LQFGDKLFMS TDATLGLYGI RIISVSKEDF
ESCSTASQSR DRFVFTDDIL NGTRQVEPKW LTPGLHYFLA SHEGDSQLCK LGLRLNVSVK
EQRCQSSPLV RLCSGNGVCR TGFWESGAYR CQCLRHYSGK FCERFRTCLD NPCEDRAVCL
SNETGRVHAT FRCFCPPKFT GLNCSDVFGR GDCCRVCRNG TCFQVFPLSF RCVCDTAHPG
LPCGTSCDPN PCRNGRVCRE SSENASGYVC ACPEGFTGPR CETPVDNNCL SYECQLCEDD
PTGPLCGRQR GPCDPSPCLN NASCSVRGED FVCRCLPGFS GKRCDEIINY CSLLHINCLH
EGICLSVIGG FNCLCAPGWM GEVCQYVGNA CLIYPDGCLN GGTCVTTSQP TDPPQYRCTC
HRDYTGPHCE SEIDDCISSP CQHNGICMDF AGFYKCRCPP GFLGLNCEVD VDACTLPNAT
CPVNMQCLDL PDGLKELIGV FPVSRPALQP CANMGRCVVN DASSYACLCA PGWTGRNCRV
NVDDCVQHWC QNGATCVDRV DGYGCLCPNG YGGARCEVDV NDCPGHRCSE RGVCLDWPGG
YTCRCDLGFE GRDCERETDE CLSSLCANGA TCEDLTGSYR CHCPPGFEGQ WCSENSDDCW
SRPCLNGGSC VDLLNGHICH CPFGWGGDDC DTPMNQCVSN PCDPGGTLYC KELANDFRCV
CQHGYVGRLC ETPISHCVDG LCHHGSKCVD LLRGFECRCL PGSTGRFCEV KTDNCRAEPC
GPLSLCKDTV NGYSCFCAPG FIGNNCETEV NECLSQPCQN GATCSDELNG FSCRCPVGIT
GDNCELNIDE CLSSPCRHNS TCVDLANGYE CLCLPGFTGA ECELDVDECA SSPCKNGATC
IDQPGNYHCQ CLTPFKGQNC EFLPCEANNP CENGAECVEE PDRLHFPLGF SCRCGRGFAG
PRCEINVDEC SSDPCLHGFC YDVVDGFYCL CNPGYAGVRC EHGVDDCSDN MCINNSTCRD
LHLSYECLCL PGWEGEFCQR EVDECSSQPC QNNATCSDLL NGYRCECLQG WAGRDCTDDI
NECDSQPCLN GARCQESHLP GEFSCTCPPF FTGPLCNVPF DPCDPAHDPC LHNATCLTRS
NGTAVCRCQP GELLWYSWPG LRVDKFRCNC PPGYFGVLCD LDVNECEVSP CLQEGTCINR
PGGFKCVCRP GYAGTWCELS IDECVSNPCR NGGSCVDGPN RYQCLCGGGF VGFHCEINTD
ECVSGPCHHG RCIDGVDAYI CHCELGWTGE RCEMNVDECT SVPCLNGGTC LDLVDKYACF
CLDGHSGKNC EIDVDVCLES PTNVSLCLNG GTCLDGTGAN FTCSCTAGFI GDFCEVNTNE
CCSDPCLHGA ICQDLVNGYL CHCRAGWTGL HCELDINECL PQPCNQGMCI QNEPGYGYTC
FCRPGFVGKS CEHNYDDCLL QPCPAGYTCV DGINGVSCQP AEGDMSSVPW EPVLTPPPRE
SLVTASPASP VSEYGEQPTD SSYIQYFGNS YLEFEGIDLG ANNNITVRFQ TWEPQGTLLY
VDQGAVTRGF FFMKLFIQDG MLQYAFSCNQ EEGVRRINTS QRVDNGSPFI VYVRQHLAPC
EAEVVLSGHE RVRSRPSNYW SGLTIQRTSH LFIGGLPHRY QPYQGAKPFS NYTGCIEIVE
MNKLRGFYTS SAIAGSNVDH CRPQPPPPAP TRPLQLPPAP TQPPTLICHA HLCRNGGSCR
EQQSPGGDLS FYCDCPLHFT GLLCEKDATI FIPSFNGTSH LELPPVASLL QAPGAVLSFH
LKNNLQLITS SLLFSAREEN FGDRFLHVFL QDGIPVVNLG CGGVHLLKAE ADQAINTNRL
TSITIRYRVP GSRSEGSCMI EIGVDNGTMK RQEEPQFQSL SEAAFGPIFL GDVPSDRDPP
DSSREVTGFV GCIQELHINS KEVYITAEAL GGRNIHNCAT PVCQHLPCRH GGTCVSDAED
WYCECPPLFS GRLCQFTACQ WSPCAHGATC IPKSPLEVVC LCPYGRQGLL CDEVVDITRA
RFSGNDEFGY TSFAAYSSIP SLSLYYEFQL KVTFADNALA LKDNLILFSG LKGQGVDGDD
FLVLGVRNGR IVHKFNLGSG VGTIVSDRIN RSIDIHTVNF GRSLRTGWLK VDGQRNRTAS
SPGHLVGLNA LSQVFVGGYN EYTPELLPLG SRFRNGFQGC IFDVEFRTRR DGKFIPLGSP
EGHPNSGRSV GQCGVTPCTL VTCRNGGTCV DSGSSVYCQC PFGWKGALCS ETVSVCDAEH
SPPPLCAQGS TCIPLPEGYT CLCPLGTGGL HCQQAMTISD PFFSSNQLSW MSFPPTSMRH
STDLWLQFQT LSPEGILFYT AQHLSTRAGD FFCVSLTTAR VQFRYNLGSG TNVLQSRNTV
DTSGGTWHTL RAGRTGHRGY LVLDGVEVKQ NDTEGTMTTL DVATDLFVGG VSDLSAISPF
AVEDAPTGFT GGMRELILNG HDFDLSETGA VGGANVGDWD GTACGYKVCR NGGRCGASSD
VGSDSFTCAC PPTWTGRVCN QSVYCVGNLC QHGSLCFSAP AAGTYSCVCP LGWEGTYCDQ
PVGVGMTTLR FVGNSYVKYR DPRFNTRNLR YTRVSFNLTT NESEGLILWM GRAGHDDDDY
LAVGISGGSL KIAVNLGERL TPPFTVRNAT LCCDKWHYLS VSLDGTMMQV FLGDVRVLNE
DVDPFERYVA LNYGGQMYFG GFELHRNISV VTSGLFRKGF TGDLKDVSLY QDRLEILQNS
EGFNVNKGIE
//
