ID A0A3P9A1K6_ESOLU Unreviewed; 349 AA.
AC A0A3P9A1K6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000035040.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000035040.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000035040.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
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DR RefSeq; XP_012991475.1; XM_013136021.2.
DR RefSeq; XP_019906785.1; XM_020051226.1.
DR RefSeq; XP_019906788.1; XM_020051229.1.
DR RefSeq; XP_019906792.1; XM_020051233.1.
DR RefSeq; XP_019906797.1; XM_020051238.1.
DR AlphaFoldDB; A0A3P9A1K6; -.
DR STRING; 8010.ENSELUP00000035040; -.
DR Ensembl; ENSELUT00000038637.2; ENSELUP00000035040.1; ENSELUG00000013813.2.
DR GeneID; 105031608; -.
DR KEGG; els:105031608; -.
DR GeneTree; ENSGT00940000158523; -.
DR InParanoid; A0A3P9A1K6; -.
DR OMA; KTRRWIL; -.
DR OrthoDB; 2874082at2759; -.
DR Proteomes; UP000265140; LG02.
DR Bgee; ENSELUG00000013813; Expressed in brain and 9 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR GO; GO:0009888; P:tissue development; IEA:UniProt.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR013300; Wnt7.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027:SF78; PROTEIN WNT-7A; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01891; WNT7PROTEIN.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
SQ SEQUENCE 349 AA; 39189 MW; 4D34B2E83C7BBCB6 CRC64;
MSRKTRRWIF HMFLCLGIVY LKIGGFSSVV ALGASIICNK IPGLAPRQRT ICQSRPDAII
VIGEGAQMGI NECQFQFKNG RWNCSALGER TVFGKELKVG SKEAAFTYAI IAAGVAHAIT
AACTQGNLSD CGCDKDKQGT YSQDEGWKWG GCSADVRYGL GFSKVFVDAR EIKQNARTLM
NLHNNEVGRK VLEKSMHLEC KCHGVSGSCT TKTCWTTLPK FRQLGYMLKD KYHQAVHVES
VRATRHKRPT FLKVKKPHSY RKPMDTDLVY IEKSPNYCEA DLVTGSMGTQ GRLCNKTALQ
TNSCDLMCCG RGYNTHQYSR VWQCNCKFLW CCYVKCNTCS ERTEVYTCK
//
