ID A0A3P9A2X1_ESOLU Unreviewed; 176 AA.
AC A0A3P9A2X1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Cyclin-dependent kinase inhibitor 1 {ECO:0000313|Ensembl:ENSELUP00000035367.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000035367.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000035367.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000035367.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CDI family. {ECO:0000256|ARBA:ARBA00006726}.
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DR RefSeq; XP_010879795.1; XM_010881493.3.
DR AlphaFoldDB; A0A3P9A2X1; -.
DR Ensembl; ENSELUT00000023011.2; ENSELUP00000035367.1; ENSELUG00000014322.2.
DR KEGG; els:105017129; -.
DR GeneTree; ENSGT00940000159918; -.
DR OrthoDB; 692679at2759; -.
DR Proteomes; UP000265140; LG17.
DR Bgee; ENSELUG00000014322; Expressed in testis and 15 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IEA:InterPro.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IEA:InterPro.
DR GO; GO:0072331; P:signal transduction by p53 class mediator; IEA:InterPro.
DR Gene3D; 4.10.365.10; p27; 1.
DR InterPro; IPR003175; CDI_dom.
DR InterPro; IPR044898; CDI_dom_sf.
DR InterPro; IPR029841; CDKN1A.
DR PANTHER; PTHR46778:SF1; CYCLIN-DEPENDENT KINASE INHIBITOR 1; 1.
DR PANTHER; PTHR46778; CYCLIN-DEPENDENT KINASE INHIBITOR 1-RELATED; 1.
DR Pfam; PF02234; CDI; 1.
PE 3: Inferred from homology;
KW Protein kinase inhibitor {ECO:0000256|ARBA:ARBA00023013};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 26..75
FT /note="Cyclin-dependent kinase inhibitor"
FT /evidence="ECO:0000259|Pfam:PF02234"
FT REGION 136..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 176 AA; 19636 MW; 591F88FCD70E3D1F CRC64;
MCRTGTTMAS RTSVLTYLGE SSARRNLFGP VDHEQLQQEY QDALNRDLEA ACYRWGFDFR
SEKPLAQGHF QWDGVPEAGV PLLYRPCAVG QGGAQRVGGP ADSAGRVWVG LSHCGRENIS
CTPVKYRGNC HNLEETPEKE ENKNSNENGL KRKQTNLTDF YQSKKRVVGT PRKSGQ
//
