ID   A0A3P9A395_ESOLU        Unreviewed;       777 AA.
AC   A0A3P9A395;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Cullin-1 {ECO:0000313|Ensembl:ENSELUP00000035497.1};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000035497.1, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000035497.1, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000035497.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_010892380.1; XM_010894078.2.
DR   RefSeq; XP_019901117.1; XM_020045558.1.
DR   AlphaFoldDB; A0A3P9A395; -.
DR   STRING; 8010.ENSELUP00000014433; -.
DR   Ensembl; ENSELUT00000038908.2; ENSELUP00000035497.1; ENSELUG00000000528.2.
DR   GeneID; 105024245; -.
DR   KEGG; els:105024245; -.
DR   GeneTree; ENSGT00940000154774; -.
DR   InParanoid; A0A3P9A395; -.
DR   OMA; IREWDRY; -.
DR   OrthoDB; 5474206at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000265140; LG03.
DR   Bgee; ENSELUG00000000528; Expressed in testis and 15 other cell types or tissues.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF169; CULLIN-1; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          418..645
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
FT   REGION          60..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   777 AA;  90025 MW;  9F8B9B17EA4C9593 CRC64;
     MSSNRSQNPH GLKQIGLDQI WDDLRAGIQQ VYTRQSMAKS RYMELYTHVY NYCTSVHQSN
     QARGAGPPPS KPSKKAPTPG GAQFVGLELY KRLKEFLKNY LTNLLKDGED LMDESVLKFY
     TQQWEDYRFS SKVLNGICAY LNRHWVRREC DEGRKGIYEI YSLALVTWRE CLFRPLNKQV
     TNAVLKLIEK ERNGETINTR LISGVVQSYV ELGLNEDDAF AKGPTLSVYK EYFETQFLAD
     TERFYTREST EFLQQNPVTE YMKKAEARLL EEQRRVQVYL HESTQDELAR KCEQVLIEKH
     LEIFHTEFQN LLDADKNEDL GRMYNLVSRI TDGLGELKKL LETHIYNQGL AAIEKCGEAA
     LNDPKMYVQT ILDVHKKYNA LVMSAFNNDA GFVAALDKAC GRFINNNAVT KMVQSSSKSP
     ELLARYCDSL LKKSSKNPEE AELEDTLNQV MVVFKYIEDK DVFQKFYAKM LAKRLVHQNS
     ASDDAEASMI SKLKQACGFE YTSKLQRMFQ DIGVSKDLNE QFKKHLTNSE PLDLDFSIQV
     LSSGSWPFQQ SCTFALPSEL ERSYQRFTAF YASRHSGRKL TWLYHLSKGE LVTNCFKNRY
     TLQASTFQMA ILLQYNTEDV YTVQQLTDST QIKIDILVQV LQILLKSKLL VLEDENANVD
     EVEFKPDTLI KLFLGYKNKK LRVNINVPMK TEQKQEQETT HKNIEEDRKL LIQAAIVRIM
     KMRKMLKHQQ LLAEVLNQLS SRFKPRVPVI KKCIDILIEK EYLERVDGEK DTYSYLA
//