ID A0A3P9A3L9_ESOLU Unreviewed; 632 AA.
AC A0A3P9A3L9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Heterogeneous nuclear ribonucleoprotein R {ECO:0000313|Ensembl:ENSELUP00000035592.2};
GN Name=HNRNPR {ECO:0000313|Ensembl:ENSELUP00000035592.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000035592.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000035592.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000035592.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P9A3L9; -.
DR STRING; 8010.ENSELUP00000035592; -.
DR Ensembl; ENSELUT00000038987.2; ENSELUP00000035592.2; ENSELUG00000014625.2.
DR GeneTree; ENSGT00940000153511; -.
DR Proteomes; UP000265140; LG15.
DR Bgee; ENSELUG00000014625; Expressed in brain and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd21067; NURR_hnRNPR; 1.
DR CDD; cd12250; RRM2_hnRNPR_like; 1.
DR CDD; cd12494; RRM3_hnRNPR; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR041337; hnRNP_Q_AcD.
DR InterPro; IPR006535; HnRNP_R/Q_splicing_fac.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01648; hnRNP-R-Q; 1.
DR PANTHER; PTHR21245; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; 1.
DR PANTHER; PTHR21245:SF5; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN R; 1.
DR Pfam; PF18360; hnRNP_Q_AcD; 1.
DR Pfam; PF00076; RRM_1; 3.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR PROSITE; PS50102; RRM; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 166..246
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 248..330
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 343..413
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..632
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 632 AA; 71183 MW; 3AD9C9FA26E53D9E CRC64;
MRMAAEVNGS SALTKEEEEP MDITVTHTEN YQTLIDAGLP QKVAENLDNI FQTGLVAYAD
LDERAIDALR EFNEEGALSV LLQFKESDLS HVQNKSAFLC GVMKTYRQRE KQGSKVQEST
KGPDETKIKA LLERTGYTLD VTTGQRKYGG PPPEHVFSGA QPGIGTEVFV GKIPRDLYED
ELVPLFEKAG PIWDLRLMMD PLLSGQNRGY AFITFCNKEA ALEAVKLCDN YEIRSGKYLG
VCISVANNRL FVGSIPKNKT RESILEDFSK VTEGLMEVIL YHQPDDKKKN RGFCFLEYED
HKTAAQARRR LMSGKVKVWG NPVTVEWADP VDEPDPEIMA KVKVLFVRNL ATPVTEELLE
KTFSQFGKLE RVKKLKDYAF VHFEERDAAV KAMQEMNGKE LEGEEIEIVL AKPPDKKRKE
RQAQRQPSRY DDYYYYPAPR MPPPMRGRGR GGRGGYSYPA DYCGYEDYYD DYYSGGYDYH
DYRGGYDDPY YSGYDDPYAP RGRAGRAGRG APPPPRGRGA PPPRGRGGYV QRGAPMGVPR
GGRGGRGGPP QQQRGRGVRG QRGNRGGNMG GKRKADGYNQ PDSKRRQTNS QNWGSQPIAQ
QPLQQGGDYS GNYGYNNDNQ EFYQDSYGQQ WK
//
