ID A0A3P9A4Z3_ESOLU Unreviewed; 565 AA.
AC A0A3P9A4Z3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Voltage-dependent L-type calcium channel subunit beta-4 {ECO:0000313|Ensembl:ENSELUP00000036077.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000036077.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000036077.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000036077.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_012992015.2; XM_013136561.2.
DR AlphaFoldDB; A0A3P9A4Z3; -.
DR Ensembl; ENSELUT00000024366.2; ENSELUP00000036077.1; ENSELUG00000015287.2.
DR GeneID; 105026314; -.
DR KEGG; els:105026314; -.
DR GeneTree; ENSGT00950000182837; -.
DR OrthoDB; 2953516at2759; -.
DR Proteomes; UP000265140; LG12.
DR Bgee; ENSELUG00000015287; Expressed in brain and 10 other cell types or tissues.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR046937; CAB1-4_N_A-dom.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR008079; VDCC_L_b3su.
DR InterPro; IPR000584; VDCC_L_bsu.
DR PANTHER; PTHR11824; VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT; 1.
DR PANTHER; PTHR11824:SF8; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF12052; VGCC_beta4Aa_N; 1.
DR PRINTS; PR01626; LCACHANNELB.
DR PRINTS; PR01696; LCACHANNELB3.
DR SMART; SM00072; GuKc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 220..398
FT /note="Guanylate kinase/L-type calcium channel beta
FT subunit"
FT /evidence="ECO:0000259|SMART:SM00072"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..508
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 63876 MW; D966078F7BFE678A CRC64;
MVQVKMSKSS ADPLSGVETG SQSHNFQLPR KLPKRKSRFK RSDDSTSSDT TSSFIKRQGS
ADSYTSRPSD SDLSAEEDRE AYRREAERQA QLQLDRAKSK AVAFAVKTNV SYCGALDEDC
PVQGAAINFE AKDFLHIKEK YNNDWWIGRL VKEGADITFI PSPLRLEAMR LKHEQKQRKS
GGNSTSLGDM VPGNWRTTPP SGDKLKQKQE HIPPYDVVPS MRPVVLVGPS LKGYEVTDMM
QKALFDFLKH RFDGRISITR VTADLSLAKR SVLNKRPIME RSNTRSSLAE VQSEIERIFE
LAKTLQLVVL DADTINHPAQ LAKTSLAPII VYVKVSSPKV LQRLIKSRGK SQSKHLNVQM
MAGDKLSQCP PDMFDVILDE NQLEDACEHL AEYLEVYWRA THLPSPTLIN PLLEEDHVTP
PTTISSLQNK NQSPAQHGNV GEKRRWGDEA HSPLEQDSLM PSEEGSDSLS RGLRGGPHVQ
KGEEDEEEEL VEELEEELDE EDEEEFESPC NTQTYRYPPQ RGHHGGIHSA NGHESQDKLL
QRDAQQGHNE RNNRQRSRPW PRDNY
//
