ID A0A3P9A7C9_ESOLU Unreviewed; 2159 AA.
AC A0A3P9A7C9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=FRAS1 related extracellular matrix 1 {ECO:0000313|Ensembl:ENSELUP00000037086.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000037086.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000037086.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000037086.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR Ensembl; ENSELUT00000026288.2; ENSELUP00000037086.2; ENSELUG00000016724.2.
DR GeneTree; ENSGT00940000156990; -.
DR Proteomes; UP000265140; LG24.
DR Bgee; ENSELUG00000016724; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR CDD; cd00037; CLECT; 1.
DR Gene3D; 2.60.40.2030; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR045658; FRAS1-rel_N.
DR PANTHER; PTHR45739:SF7; FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 1; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 1.
DR Pfam; PF19309; Frem_N; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF141072; CalX-like; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS51854; CSPG; 12.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..2159
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030079224"
FT REPEAT 294..388
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 411..498
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 519..613
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 638..752
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 774..865
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 886..980
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1025..1127
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1148..1256
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1277..1373
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1394..1485
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1502..1593
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1624..1721
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT DOMAIN 2039..2145
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT REGION 1851..1871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2159 AA; 239421 MW; 69D130F2A2923480 CRC64;
MLLTLPMLLL VLPGASHSSL VKTNLGLRVK RGRSACLQEG DLQFHIPHVK DACKVEVVLN
EPITQRVGTL SPQVFDCHYL ADEVKYVHNG CPILKEDTVK LRLYRFTETE TFTEVFSLRV
EVMEPDCNII KPGLKSLVVP EFYGLSDTLD GNVLSFHYER MTSLECSIHV DTHETHLPAH
GQLVTGEPKQ LEARGDEPES FIPLRQKLDN KARAMCKTED CLRGLKLAKV TKVPCDEFLL
MGLRYQHIDP PSPDVDYIAI RLDLTDTRSG GIYQSERVWI PIHITGAVHN QPPKPAFMSM
FLLEVDQFIL TPLSTATLDA DDGETPKKLL VFNVTKPPSE GFITHLSDHT RPISSFTWVD
LNDMLIGYQP PNSSHTQRRN YEAEFEVHDF FFEKSPPIVV HMSVRTADTN APRVSWNMGL
SLLEGQSRPI TWDQLQIVDN DNLKPVRVIT VDGLQHGRLT LKGGKGFMFT VADIHAGDVR
YHHDDSDTTK DFVIFRITDG RHQTRHKFPI NILPKDDSPP FLITNTVLEL SEGHTALLRG
SVLQASDMDS SDDYILFNVT RPPQAGELMK IPGPGLTGYP VSRFLQKDLF HSVVYYRHLG
NEVFDDSFEV VLSDFHDPPN LSEPQVIVVH INPVPDQPPK EVPGVTRCLV ARETEVIHLT
KKQLHFTDPE SPDSELTYTV TTPPFFVHTY GGHDAGRLFL VDSIPTFRKD PDAPVLRLFT
QHAVNHMKVA YMPPSVDIGP YPQHIQLVLS VTNQQGTTVP GICFNITVLP VDNLAPEVHM
KSPTVDEGGE CLVGVHHLQL TDHDSMEDQL RVELKKEPQH GAVQLDGFPM KPGQSFTVRD
LKSLKVRYRH DSSETVGDTI EFIATDGINP VEFVLEVKVT LVNDEVPVLM PDLKPVLDCA
EGQEVIITVE YIYATDVDSD DGGLTYMIAR QPHHGVVRKN AVVVDRFVQA DIVAGIITYK
HTGTEIGLSP RHDTITFVIS DSQAENAPLC CGGRGDTFKG HQTSIQESLP LYDLKVTVFP
VDSQTPSIGT GEIVVVDEGG VAPITAAHLR ALDVDTPLDM LVVSLVVPPQ YGYIENTLPT
PGFEKSNTGI SIASFSYGDI LKGHVNYVQS RHQRIEPTAD QFILCVSDGK HTSANVPFYI
LISPINDEVP EFLARNITVQ EGHMKQLDPA VINAVDLDIP KNELKFSLIQ APQHGSIMGR
TYGSGLPPNG GTNHRHWDAE VLLHDFTMEE LRNGMSLMYM HDDSENMVDT FTIQLTDGKH
QLQRQVTVNV LPVNDEEPRV VRNNGLEVEA GDARLISSAS LFAQDGDTPS QEIVYMLEKV
PTQGLLQVKV GSDWVTQSAG MTCTQETVDM NRLRYLHTGP LGATQDFFTF HLLDGNNRSP
AQHFHISLKD MEKGNIAIFV KPVKTSRGER VILTTDVLLA TDGTDKPEEL LYIITVPPRH
GHMEYIKHPG VAISTFSQMD IAANLVGYVH DNRGTAQFVI SNGKTTRNGT LEISVETTDR
ILPSLVSNSG LRVPQGSSMV LTPQALALSD PDTPPADLTF VVAQPPQYGA LLRGGVPLAA
GGNFTQWDLQ EQGVTYTHSG GPSEIDRFAF TASDTTDRGF LLEGRLQTEP VVFTIQIELL
DSTAPEVAQL QSLWKAEALS DGRYGIYLSS RELRAQDANT KDEDLTFHIH RPPYFGYLEN
SATGSFVQQR FTQWDLNRRT IVYVIDPATE ALSDSLEFRV SDPLGNTGPS HTLELKWCRV
ELAGSEYQAC EDEGAVSLDI LRKGSVADSS YITIKVREGT ATAGKDFILS PSSLIQFDPG
VSKRSWRIEI TQDHLEEAEE TFEVVLVAPE GALLGSTSKA LVKIRDAGKG QCGAGQGPAS
SSLGGKQVQA GPYPQHGSIH LEALPLAPVD QQVTWTLGDG VSQAVPADVH ATVPVEPRKI
LRVVGNRKAI APSSVHRNGT DTVFTYHGIT SLRVEDETSP SRKGRKANIQ VTSRGRGLDV
LELPGNFSPK PCVPGLMGLL HFNQSSGRLH YCNGVSWRPW APTDEMVRGQ ACGKGWTYHN
GYCFLLSTER KATWSTAFKA CRESHQASLV SISSKADMDW LWDFSERKPF WIGLNDRESR
GRWEWAGGEP VTYTNWRKSP ARGTRKGTKR CVLVWRKAKW QPRDCKAGKG HRYVCYLKT
//
