ID A0A3P9A7J3_ESOLU Unreviewed; 436 AA.
AC A0A3P9A7J3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Equilibrative nucleoside transporter 1 {ECO:0000313|Ensembl:ENSELUP00000036598.1};
GN Name=SLC29A1 {ECO:0000313|Ensembl:ENSELUP00000036598.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000036598.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000036598.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000036598.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC {ECO:0000256|ARBA:ARBA00007965}.
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DR RefSeq; XP_019902045.1; XM_020046486.1.
DR AlphaFoldDB; A0A3P9A7J3; -.
DR Ensembl; ENSELUT00000039627.2; ENSELUP00000036598.1; ENSELUG00000015955.2.
DR GeneID; 105014368; -.
DR KEGG; els:105014368; -.
DR GeneTree; ENSGT00950000182898; -.
DR OrthoDB; 517168at2759; -.
DR Proteomes; UP000265140; LG05.
DR Bgee; ENSELUG00000015955; Expressed in spleen and 7 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015213; F:uridine transmembrane transporter activity; IEA:UniProt.
DR InterPro; IPR034764; ENT1/ENT2.
DR InterPro; IPR002259; Eqnu_transpt.
DR NCBIfam; TIGR00939; 2a57; 1.
DR PANTHER; PTHR10332; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR PANTHER; PTHR10332:SF9; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; 1.
DR Pfam; PF01733; Nucleoside_tran; 1.
DR PIRSF; PIRSF016379; ENT; 1.
DR PRINTS; PR01130; DERENTRNSPRT.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 21..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 436 AA; 47887 MW; 3AE715AE3B3D10DC CRC64;
MVKLGSGPVD SIPSRERNHA VWLIFFMLGL GTLLPWNFFM TATMYFTGRL GVPEDGGNRN
SMEASYNNVS TLCAMLPLLV FTCLNSFLHQ RVPQRLRIIG SLAVIFLLFL TTAIVVKIEM
APLPFFVITM ITIVIINSFG AILQGSLFGM AGILPAKYTT PIMSGQGLAG TFAAFSMICA
IASGSKLNDA AFGYFITACV VILLTIVSYL VLHKLEFYQH YNQSQVESPV SDENNLDLLE
GENTAETGSV FNLEEGEQSV SIWAIFKKIW VMALSVCLAF TVTISTFPAV TVDVKSQITE
GGTWEMYFIP VGCFLLFNIS DWAGRSLTAM CLWPGKTSIL LPIFMTARAV FVPLFMLCNV
QPRHHLPVVF EHDAWFVVFI ITFAFSNGYL ASLCMCFGPK LVAPHEAETA GAIMAFFLSL
GLALGAAFSF LFRAII
//
