ID A0A3P9A8Q5_ESOLU Unreviewed; 610 AA.
AC A0A3P9A8Q5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Sodium/potassium/calcium exchanger 3 {ECO:0000313|Ensembl:ENSELUP00000037413.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000037413.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000037413.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000037413.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in)
CC + 4 Na(+)(out); Xref=Rhea:RHEA:69967, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:29103, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033627};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC24A subfamily. {ECO:0000256|ARBA:ARBA00005364}.
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DR RefSeq; XP_010868899.1; XM_010870597.2.
DR AlphaFoldDB; A0A3P9A8Q5; -.
DR Ensembl; ENSELUT00000026931.2; ENSELUP00000037413.1; ENSELUG00000017065.2.
DR GeneID; 105010914; -.
DR KEGG; els:105010914; -.
DR GeneTree; ENSGT01030000234532; -.
DR InParanoid; A0A3P9A8Q5; -.
DR OMA; FIRIAMA; -.
DR OrthoDB; 22570at2759; -.
DR Proteomes; UP000265140; LG07.
DR Bgee; ENSELUG00000017065; Expressed in digestive tract and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004481; K/Na/Ca-exchanger.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00367; calcium/sodium antiporter; 1.
DR PANTHER; PTHR10846; SODIUM/POTASSIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR10846:SF28; SODIUM_POTASSIUM_CALCIUM EXCHANGER 3-LIKE ISOFORM X1; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 94..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 489..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 589..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 98..239
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 455..605
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 367..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 610 AA; 66966 MW; 73178E07ECCFE2F5 CRC64;
MKAAVQTGRR WPFQRFCCGG VGLLAVIWLA QVAHVTEPDS SGSHLREDDI PVHSGRRLMQ
ERTEENRTKD ILRPAIHEFP EDIFTKEQLK RGAVLLHVLC AIYMFYALAI VCDDYFVPSL
EKISENLQLS EDVAGATFMA AGSSAPELFT SLIAVFITKG DVGVGTIVGS AVFNILVIIG
VCGIFAGQAV DLTWWSLFRD STYYIFSVLA LILVIYDAKV VWWEAVLLMS MYVVYIVIMK
FNSQLLGCVQ RHSGGPSQCC RGSEGHRDEE MAGDGPACNT SMVLLKKGQP QVPESPPVVM
VDELLILHPH QLSFSEAGLR IMITPHFSPR TRLSMAGRML ISERQRLIRC PNSQLYGASG
VGGTPLKAAG SGGLENGGSV ERQSPDGAVP GDAGEKPGME GCQAEEEDDG EGPFRPLHWP
GGCCARVKWL ISWPLGLLLY CTVPNCVFPR WHRWFMVTFL ASTLWIAIFS YLMVWMVTVI
SYTLDIPDYI MGITFLAAGT SVPDCMASLI VARQGMGDMA VSNSIGSNIF DILLGLGFPW
ALRTLVVDSG SSVHINNKGL VYSVVLLLAS VFLTVMSVHL NHWKLDRRLG LGLIFLYAIF
LLSSILFGQM
//
