ID A0A3P9A9H2_ESOLU Unreviewed; 167 AA.
AC A0A3P9A9H2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Gremlin 2, DAN family BMP antagonist {ECO:0000313|Ensembl:ENSELUP00000037274.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000037274.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000037274.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000037274.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR RefSeq; XP_010894177.1; XM_010895875.3.
DR AlphaFoldDB; A0A3P9A9H2; -.
DR STRING; 8010.ENSELUP00000037274; -.
DR Ensembl; ENSELUT00000040057.2; ENSELUP00000037274.1; ENSELUG00000016885.2.
DR GeneID; 105025290; -.
DR KEGG; els:105025290; -.
DR GeneTree; ENSGT00940000154209; -.
DR InParanoid; A0A3P9A9H2; -.
DR OMA; RRQHLNK; -.
DR OrthoDB; 5347549at2759; -.
DR Proteomes; UP000265140; LG06.
DR Bgee; ENSELUG00000016885; Expressed in spleen and 9 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR PANTHER; PTHR15283; GREMLIN 1; 1.
DR PANTHER; PTHR15283:SF2; GREMLIN-2; 1.
DR Pfam; PF03045; DAN; 1.
DR SMART; SM00041; CT; 1.
DR PROSITE; PS01225; CTCK_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00039}; Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..167
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018125222"
FT DOMAIN 72..138
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT REGION 25..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 72..122
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
SQ SEQUENCE 167 AA; 19082 MW; DD25C90F0C228AEB CRC64;
MYRQFVLSLL LAGVLCAVGG DTRKTRPQGS IPSPFKGNGN TSDRRARKQE VLASSQEALV
VTERKYLKSD WCKTQPLRQT VSEEGCLSRT VINRFCYGQC NSFYIPRHVK KEQESFQSCA
FCRPQRFTTL TVELDCPDLQ PPFRHRKIQR VKQCRCISVS VSDSGRQ
//
