ID A0A3P9AAN6_ESOLU Unreviewed; 774 AA.
AC A0A3P9AAN6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=F-BAR and double SH3 domains protein 2 {ECO:0000313|Ensembl:ENSELUP00000037782.2};
GN Name=FCHSD2 {ECO:0000313|Ensembl:ENSELUP00000037782.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000037782.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000037782.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000037782.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_010869103.1; XM_010870801.2.
DR AlphaFoldDB; A0A3P9AAN6; -.
DR STRING; 8010.ENSELUP00000037782; -.
DR Ensembl; ENSELUT00000027602.2; ENSELUP00000037782.2; ENSELUG00000017539.2.
DR GeneID; 105011044; -.
DR KEGG; els:105011044; -.
DR GeneTree; ENSGT00510000046732; -.
DR InParanoid; A0A3P9AAN6; -.
DR OMA; HMKGYLV; -.
DR OrthoDB; 3674259at2759; -.
DR Proteomes; UP000265140; LG07.
DR Bgee; ENSELUG00000017539; Expressed in liver and 15 other cell types or tissues.
DR CDD; cd11894; SH3_FCHSD2_2; 1.
DR CDD; cd11761; SH3_FCHSD_1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR035556; FCHSD2_SH3_2.
DR InterPro; IPR035460; FCHSD_SH3_1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15735:SF11; F-BAR AND DOUBLE SH3 DOMAINS PROTEIN 2; 1.
DR PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 8..282
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 465..526
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 572..634
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 421..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 138..168
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 363..397
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 437..451
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 774 AA; 86697 MW; B6DCBDCA0B03ECD7 CRC64;
MQPPPRKVKV TQELKHTHAE QLSRLHIKHH TECDLLEDLR TYSQKKAALE RDYAQALHKL
AYQYLKREWP DSLPEEPTDH RNMYTVWKAY LEGTAQVTQS RITACENYRN QVSDPAKTAR
LQKEQQLKKC IDQLTVVQAE LQDSVKELAK TKKKYQEAET MAQAVRDKAE QDAKSKLSLF
QSRSSLQRAN VKLKAKRGEC NSKATHARND YLLTLAAANA HQQRYYDTDL IDCIKVLDGA
IYDQVKDYLV SLCQTEIEAY KAVHDTFSVL LERSNGVMQE FHRQQFVQQN PVFHSAPAIL
FQPSDTDTVL QLQKESGTVE EHSLDKEARK WATRVAREHK SIIHCQRALE DYRTQQGPSE
QNRSELELKM EEARENLRRA ETVKLKAEAR LDLLREAGVT VETWLKSAMN QVMEELENER
WANLNANDPS ISGTADLERE DEEELEDSGE VLDDSSSSPS STLRNYPLTC KVLYSYKASQ
PDELTIEEQE VLEVIDDGDM EDWVKARNRT GHVGYVPEKY LQLPTSNSLL SMLQSLSALD
ARSHSSNNST EPELAESELP PPGMPSINGD LSSVCFAKAL YDYAGQTDEE LSFPEGAIIR
VLSRETHEDD GFWEGEFNGS VGVFPAVLVE DLLAAGDGDD KNGNIPGKAS TSAQASPSPL
SQRSPRSPFQ LGPFHSSPLQ TPTLPSPQSS PSSASASPIS RPPSYINGHH RPPPAPLKSP
LQSPAQNSTQ PPKYPADGGV GGNIRPVRAA PPPPQPQQPR GQVKRREEVE ITLV
//
