ID A0A3P9AAX2_ESOLU Unreviewed; 497 AA.
AC A0A3P9AAX2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Inositol polyphosphate 5-phosphatase K {ECO:0000313|Ensembl:ENSELUP00000037855.2};
GN Name=INPP5K {ECO:0000313|Ensembl:ENSELUP00000037855.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000037855.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000037855.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000037855.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase
CC type II family. {ECO:0000256|ARBA:ARBA00005910}.
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DR AlphaFoldDB; A0A3P9AAX2; -.
DR Ensembl; ENSELUT00000027769.2; ENSELUP00000037855.2; ENSELUG00000000699.2.
DR GeneTree; ENSGT00940000156538; -.
DR InParanoid; A0A3P9AAX2; -.
DR OMA; EEGPNDW; -.
DR Proteomes; UP000265140; LG07.
DR Bgee; ENSELUG00000000699; Expressed in camera-type eye and 4 other cell types or tissues.
DR GO; GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR CDD; cd09094; INPP5c_INPP5J-like; 1.
DR Gene3D; 2.60.40.2840; -; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR041611; SKICH.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR PANTHER; PTHR11200:SF117; INOSITOL POLYPHOSPHATE 5-PHOSPHATASE K; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF17751; SKICH; 1.
DR SMART; SM00128; IPPc; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 36..372
FT /note="Inositol polyphosphate-related phosphatase"
FT /evidence="ECO:0000259|SMART:SM00128"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 56781 MW; D62378301E8EFCED CRC64;
MSTIKYRGRG EGERGGEGER GGEGERGGEG GKGGRGSLRL HMVTWNVATA EPPDDVTSLL
YLDTQPTTDL YVIGLQEVNA APLKFLSDLL LEDSWSHHFM NTLAPREYIK VSSVRMQGLL
LLVFSKKIHV PFIRDIQTTY TRTGLFGYWG NKGGVSVRFS LYGHMMCFVN CHLAAHMDYA
LQRIDEFEYI LETQDFDLVN TPSVRDHKVV FWFGDLNFRI ADHGMHFLRS SINSGRFNLL
WERDQLLTMR KKEPFLQEFE EGPLKFKPTY KFDLNSDTYD TSSKKKWLGF NGKKRKPAWT
DRILWRIKPK NTPAAEDKEE GWASTSTHHS DYGQDEYPIK VLQDTYTCDP SYGVSDHKPV
IGIFDLEMRK QSDCPLVCVC PEGHWSADQE AVVSYTVLED FLSSTWDWIG LYKVGFKTAS
DYATYIWVKD QLPEVNEVLK VCFNKKAVPA LCGDYVLGYF SYNMQSIVGL SNNFQIIESK
RAVRDGLVPQ DVNGMNK
//
