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Database: UniProt
Entry: A0A3P9AE37_ESOLU
LinkDB: A0A3P9AE37_ESOLU
Original site: A0A3P9AE37_ESOLU 
ID   A0A3P9AE37_ESOLU        Unreviewed;       761 AA.
AC   A0A3P9AE37;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000039012.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000039012.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000039012.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       DDX15/PRP43 sub-subfamily. {ECO:0000256|ARBA:ARBA00024333}.
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DR   RefSeq; XP_010862574.1; XM_010864272.2.
DR   AlphaFoldDB; A0A3P9AE37; -.
DR   Ensembl; ENSELUT00000029940.2; ENSELUP00000039012.2; ENSELUG00000019138.2.
DR   GeneID; 105005986; -.
DR   GeneTree; ENSGT00940000155800; -.
DR   OrthoDB; 5488182at2759; -.
DR   Proteomes; UP000265140; LG25.
DR   Bgee; ENSELUG00000019138; Expressed in embryo and 14 other cell types or tissues.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd17973; DEXHc_DHX15; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR044756; DHX15_DEXHc.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF95; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX15; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT   DOMAIN          113..279
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          304..484
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..56
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   761 AA;  87233 MW;  45296C701C68658D CRC64;
     MSKRHRLDLG EDYSSKKRSD GKDRDRDRDR DERSKDRDRD RERDRDRDRD RDIKSSVVPP
     NHLLAGGGML PLKQTAMQQQ INPFTNLPHT PRYYEILKKR LQLPVWEYKE RFNDILARHQ
     SFVLVGETGS GKTTQIPQWC VDMVKGLGGP KKAVACTQPR RVAAMSVAQR VADEMDVMLG
     QEVGYSIRFE DCSSAKTILK YMTDGMLLRE AMNDPLLERY GVIILDEAHE RTLATDILMG
     VLKEVVRQRS DLKVIVMSAT LDAGKFQVYF DSCPLLTIPG RTHPVEIFYT PEPERDYLEA
     AIRTVVQIHM CEEEEGDCLL FLTGQEEIDE ACKRIKREID DLGPEVGDIK VIPLYSTLPP
     QQQQRIFESA PPRKPSGAIG RKVVVSTNIA ETSLTIDGVV FVIDPGFAKQ KVYNPRIRVE
     SLLVTAISKA SAQQRAGRAG RTRPGKTFRL YTEKAYKTEM QDNTYPEILR SNLGSVVLQL
     KKLGIDDLVH FDFMDPPAPE TLMRALELLN YLAALNDDGD LTELGSMMAE FPLDPQLAKM
     VIASCEFNCS NEILSITAML SVPQCFVRPT EAKKAADESK MRFAHIDGDH LTLLNVYHAF
     KQNHESTQWC YDNFVNYRSL MSADNVRSQL SRIMDRFNLP RRSTEFTSRD YYINIRRALV
     TGFFMQVAHL ERTGHYLTVK DNQVVQLHPS TVLDHKPEWV LYNEFVLTTK NYIRTCSDIK
     PEWLVKVAPQ YYEMGNFPQC EAKRQLERIV AKLQTKEYSQ Y
//
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