ID   A0A3P9AFB4_ESOLU        Unreviewed;       827 AA.
AC   A0A3P9AFB4;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Lipase E, hormone sensitive type {ECO:0000313|Ensembl:ENSELUP00000039380.2};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000039380.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000039380.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000039380.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the 'GDXG' lipolytic enzyme family.
CC       {ECO:0000256|ARBA:ARBA00010515}.
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DR   AlphaFoldDB; A0A3P9AFB4; -.
DR   STRING; 8010.ENSELUP00000039380; -.
DR   Ensembl; ENSELUT00000030650.2; ENSELUP00000039380.2; ENSELUG00000019974.2.
DR   GeneTree; ENSGT00730000111056; -.
DR   Proteomes; UP000265140; LG20.
DR   Bgee; ENSELUG00000019974; Expressed in nose and 15 other cell types or tissues.
DR   GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013094; AB_hydrolase_3.
DR   InterPro; IPR010468; HSL_N.
DR   InterPro; IPR033140; Lipase_GDXG_put_SER_AS.
DR   PANTHER; PTHR23025:SF1; HORMONE-SENSITIVE LIPASE; 1.
DR   PANTHER; PTHR23025; TRIACYLGLYCEROL LIPASE; 1.
DR   Pfam; PF07859; Abhydrolase_3; 2.
DR   Pfam; PF06350; HSL_N; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   PROSITE; PS01174; LIPASE_GDXG_SER; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT   DOMAIN          7..317
FT                   /note="Hormone-sensitive lipase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06350"
FT   DOMAIN          350..499
FT                   /note="Alpha/beta hydrolase fold-3"
FT                   /evidence="ECO:0000259|Pfam:PF07859"
FT   DOMAIN          667..732
FT                   /note="Alpha/beta hydrolase fold-3"
FT                   /evidence="ECO:0000259|Pfam:PF07859"
FT   REGION          554..574
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          756..789
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        760..775
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        428
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10038"
SQ   SEQUENCE   827 AA;  90694 MW;  6AE6CA5C0FEE1EEC CRC64;
     MDTKSLFAAL YSVCEENATF FSGGPNGPQG DAALRMVDTM MLIQEHAHSL EPVVSGFAAV
     YHHFDFDPHI PANGYRSLVK VVRCCILHII HKGRYITTNR RSIFFRAAHN AREMEAYCSA
     LCQLRALLYL AQRLLHDNSH GNLFFHEESG LSQSFVREYS SMHKGCFYGR CLGFQFTPAI
     RPCLQTIAIG LVAFGENYRP HQSGIGVAAS SFFTSGKYAI DPELRGAEFE RITQNLDVHF
     WKAFWNITET EVLSGLASMT STQVKVNRAI SVPPVPFDLP LVADPHLTVT IAVPSAHTGP
     GPVQMRLISY ELREGQDSEA LLSLSRSEGG AVSLSLGMKT KRSPPSRWLV VHYHGGGFVA
     QTSKSHEPYL KSWSQELGVP ILSVDYSLAP EAPFPRALEE CFYAYCWAIK NHQLLGWTGE
     NVCLAGDSAG GNLCITTSMR AASHGVRMPD GVVAAYPAIL LTAYASPSRL LTLFDPLLPL
     SVLTRCLSAY AGEEAQAEKQ VEKVSTLSMV RRDTASLLTH IKQGASNWIH SLLDPTRADT
     TNLATTGKVR KSVSEASIVS PHSDPPVPPE QASGFSLRKE PLKSHTCQDL ASHANSTPFF
     RPLISPEEVS FFLSEEEEVF ISEALSSVAI PPPEGEEGVE LEHPREFPLG FEPLRSEKLA
     EMKLATSPVV RNPYMSPLLA PDNMLRGLPP IHLVACALDP MLDDSVMFAK RLRNVNQPVT
     LCVVDDLPHG FLSLSQLSRE TREAANVCVN RIKDVFSQQD SPPEPRKHRK LERTNHCASF
     STTGDPEKLF ESPVPDKELL VVGGGATILD GEGLVDVATQ NNVDVVG
//