ID   A0A3P9AG36_ESOLU        Unreviewed;       730 AA.
AC   A0A3P9AG36;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Phosphatidylinositol-binding clathrin assembly protein {ECO:0000313|Ensembl:ENSELUP00000039599.1};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000039599.1, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000039599.1, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000039599.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PICALM/SNAP91 family.
CC       {ECO:0000256|ARBA:ARBA00008011}.
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DR   RefSeq; XP_010862261.1; XM_010863959.3.
DR   AlphaFoldDB; A0A3P9AG36; -.
DR   Ensembl; ENSELUT00000031069.2; ENSELUP00000039599.1; ENSELUG00000019993.2.
DR   GeneID; 105005785; -.
DR   GeneTree; ENSGT00950000183068; -.
DR   OrthoDB; 3667239at2759; -.
DR   Proteomes; UP000265140; LG01.
DR   Bgee; ENSELUG00000019993; Expressed in brain and 14 other cell types or tissues.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IEA:InterPro.
DR   GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0048268; P:clathrin coat assembly; IEA:InterPro.
DR   GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR   CDD; cd16985; ANTH_N_AP180; 1.
DR   Gene3D; 1.25.40.90; -; 1.
DR   Gene3D; 1.20.58.150; ANTH domain; 1.
DR   InterPro; IPR011417; ANTH_dom.
DR   InterPro; IPR014712; ANTH_dom_sf.
DR   InterPro; IPR045192; AP180-like.
DR   InterPro; IPR013809; ENTH.
DR   InterPro; IPR008942; ENTH_VHS.
DR   PANTHER; PTHR22951; CLATHRIN ASSEMBLY PROTEIN; 1.
DR   PANTHER; PTHR22951:SF16; PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN; 1.
DR   Pfam; PF07651; ANTH; 1.
DR   SMART; SM00273; ENTH; 1.
DR   SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR   SUPFAM; SSF89009; GAT-like domain; 1.
DR   PROSITE; PS50942; ENTH; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT   DOMAIN          14..145
FT                   /note="ENTH"
FT                   /evidence="ECO:0000259|PROSITE:PS50942"
FT   REGION          608..639
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          681..730
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        620..639
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        681..716
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   730 AA;  79401 MW;  F5A473335694E138 CRC64;
     MSGQSITDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIHCTN EMNVNIPQLA
     DSLFERTTNT SWVVVFKSLI TTHHLMVYGN ERFVQYLASR NTLFNLSNFL DKSGLQGYDM
     STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR GVDGVMRTMN TEKLLKTIPI IQNQMDALLD
     FNVNANELTN GVINAGFMLL FKDSIRLFAA YNEGIINLLE KYFDMKKTQC KEGLDIYKKF
     LTRMTRISEF LKVAEQVGID RGDIPDLSQA PSSLLEALEQ HLASLEGKKV KDSTAASRAS
     TLSNAVSSLA STGMSFTKVD EREKQAALEE EQARLKALKR LKELSKRPSF ATTDTSPVST
     TGGTISTAPA IDLFSTPSCS NGALKMESDL FDIQQTFKTS MQASCTGPPV ATAWADPFTS
     AEAGDDSMPN LNPFLSKPVV ETAAHLPVVS SDGVSYSSRT SAHEMFGDRY NPFTDTNSSV
     STNYKRTVRI EHSISDSFCG PTSMAQHLSH QATYPTEPSA VAGLFRGYST APQATPSGSL
     QVDFESVFGA KATGTNNMDS DDILKPTMAG SSQALCSINQ LPDKLVGDDL DSSLANLVGN
     LGIGNGTTKN DIHWSQPGEK RLTGGSNWQP KAAPNTTWNP VSMAPSVMAY PATTPTGMMG
     GFGMQPQQLA SMGMMNQPNM MYNQPVMRPP NPFSSVSSAQ PSAASSPSSQ SPLRAPGQDP
     FAQLSLKDFL
//