ID A0A3P9AJM0_ESOLU Unreviewed; 154 AA.
AC A0A3P9AJM0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Prefoldin subunit 1 {ECO:0000256|ARBA:ARBA00039325};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000040859.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000040859.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000040859.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and
CC transfers target proteins to it. Binds to nascent polypeptide chain and
CC promotes folding in an environment in which there are many competing
CC pathways for nonnative proteins. {ECO:0000256|ARBA:ARBA00024667}.
CC -!- SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type
CC subunits. {ECO:0000256|ARBA:ARBA00011695}.
CC -!- SIMILARITY: Belongs to the prefoldin subunit beta family.
CC {ECO:0000256|ARBA:ARBA00008045}.
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DR AlphaFoldDB; A0A3P9AJM0; -.
DR STRING; 8010.ENSELUP00000040859; -.
DR Ensembl; ENSELUT00000042303.2; ENSELUP00000040859.2; ENSELUG00000021482.2.
DR GeneTree; ENSGT00390000009786; -.
DR InParanoid; A0A3P9AJM0; -.
DR OMA; MFVAVPM; -.
DR Proteomes; UP000265140; LG07.
DR Bgee; ENSELUG00000021482; Expressed in stomach and 14 other cell types or tissues.
DR GO; GO:0016272; C:prefoldin complex; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR Gene3D; 1.10.287.370; -; 1.
DR InterPro; IPR002777; PFD_beta-like.
DR InterPro; IPR009053; Prefoldin.
DR PANTHER; PTHR20903:SF0; PREFOLDIN SUBUNIT 1; 1.
DR PANTHER; PTHR20903; PREFOLDIN SUBUNIT 1-RELATED; 1.
DR Pfam; PF01920; Prefoldin_2; 1.
DR SUPFAM; SSF46579; Prefoldin; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT COILED 102..143
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 154 AA; 17898 MW; 069317D6259A50E1 CRC64;
MIYQTMYQPT KPAQVRVMFE GCGLCDVLIV FNMAAPIDLE LKKAFAELQA KMIDTQQKAK
LADLQIDQLT RMKKHANLTH AEIKTLPENT RMYEGVGRMF ILQSKEDINT QLTEKQKSAE
EKIKELEQKK TYLERSVKDA EDNIREMLMS RRAQ
//
