ID A0A3P9AK85_ESOLU Unreviewed; 420 AA.
AC A0A3P9AK85;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Carbohydrate sulfotransferase {ECO:0000256|RuleBase:RU364020};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU364020};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000041074.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000041074.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000041074.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU364020}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323,
CC ECO:0000256|RuleBase:RU364020}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 2 family.
CC {ECO:0000256|ARBA:ARBA00006339, ECO:0000256|RuleBase:RU364020}.
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DR AlphaFoldDB; A0A3P9AK85; -.
DR STRING; 8010.ENSELUP00000041074; -.
DR Ensembl; ENSELUT00000042464.2; ENSELUP00000041074.2; ENSELUG00000021789.2.
DR GeneTree; ENSGT00940000156614; -.
DR InParanoid; A0A3P9AK85; -.
DR OMA; DVCSANG; -.
DR Proteomes; UP000265140; LG09.
DR Bgee; ENSELUG00000021789; Expressed in head kidney and 14 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR GO; GO:0016051; P:carbohydrate biosynthetic process; IEA:InterPro.
DR InterPro; IPR018011; Carb_sulfotrans_8-10.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005331; Sulfotransferase.
DR PANTHER; PTHR12137; CARBOHYDRATE SULFOTRANSFERASE; 1.
DR PANTHER; PTHR12137:SF4; CARBOHYDRATE SULFOTRANSFERASE 12; 1.
DR Pfam; PF03567; Sulfotransfer_2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|RuleBase:RU364020};
KW Glycoprotein {ECO:0000256|RuleBase:RU364020};
KW Golgi apparatus {ECO:0000256|RuleBase:RU364020};
KW Membrane {ECO:0000256|RuleBase:RU364020};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Signal-anchor {ECO:0000256|RuleBase:RU364020};
KW Transferase {ECO:0000256|RuleBase:RU364020};
KW Transmembrane {ECO:0000256|RuleBase:RU364020};
KW Transmembrane helix {ECO:0000256|RuleBase:RU364020}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364020"
FT REGION 43..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 420 AA; 49551 MW; 20E2A29F54616326 CRC64;
MGTSRCFRLA FLLGTVLMIL LIIIYWDDVG ALHLYPHDPH PHPTLPLPPP PSKHPPHNRP
GERRTGTPGR AGEERPLRQG TNPSDHEERR GQRRGEEEKR EEEKMKQVEK TEVEWRRQEE
RRRRITDVCS ANGTIDFPGK FRTFDQIPNR ELDHLIVDDR HEIIYCYVPK VACTNWKRVM
VVLSEGLLTP DGQPYRNPQA VPSDLIHNSS LHLTFSKFWR RYGRLSRHLM RVKLQSYTKF
LFVRDPFVRL ISAFRNKFQQ PNEDFYRQFG SVMLRRYGNG DGKGNGSYRV PESAAEAFTE
GIRPSFSEFV KYLLDPETEQ KQPFNEHWRQ VYRLCHPCQI QYDFIGTLEN LEADSDQLLR
ILGLEDQIDF PPSNRNRTST SWEQDWFAEV PEELRRKLYS LYEPDFELFG YPKPESLLHN
//
