ID A0A3P9AL37_ESOLU Unreviewed; 749 AA.
AC A0A3P9AL37;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=EF-hand domain-containing family member C2 {ECO:0000256|ARBA:ARBA00039880};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000041806.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000041806.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000041806.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating. {ECO:0000256|ARBA:ARBA00035003}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000256|ARBA:ARBA00004430}.
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DR RefSeq; XP_012994650.1; XM_013139196.2.
DR AlphaFoldDB; A0A3P9AL37; -.
DR STRING; 8010.ENSELUP00000041806; -.
DR Ensembl; ENSELUT00000042926.2; ENSELUP00000041806.1; ENSELUG00000022849.2.
DR KEGG; els:105021927; -.
DR GeneTree; ENSGT00530000063528; -.
DR InParanoid; A0A3P9AL37; -.
DR OMA; RFSCKQP; -.
DR OrthoDB; 160134at2759; -.
DR Proteomes; UP000265140; LG20.
DR Bgee; ENSELUG00000022849; Expressed in mesonephros and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR Gene3D; 2.30.29.170; -; 3.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR006602; DM10_dom.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR040193; EFHC1/EFHC2/EFHB.
DR PANTHER; PTHR12086; EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12086:SF11; EF-HAND DOMAIN-CONTAINING FAMILY MEMBER C2; 1.
DR Pfam; PF06565; DM10_dom; 3.
DR SMART; SM00676; DM10; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS51336; DM10; 3.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 75..182
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
FT DOMAIN 226..365
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
FT DOMAIN 427..534
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
SQ SEQUENCE 749 AA; 85641 MW; 936820DBEBC8E143 CRC64;
MALPMLPGNY INKNLGKEKF HKSQHFDYSN GVPMMVGLEK PGIGGELLLG QKARPNYSVF
PKGQGCETPS WVAFDKQVLC FDAFFQETVP QKQEEKYRVR KCKIYFYLED DTIQVVEPEV
KNSGIPQGTL IRRHRIPLPP PDGERCYTVH DFNVNQPMVL HSRTFTITDC DPFTRNFLRK
IGVRLNAPTA PPPDPYSDLR QQMEENMKPQ RPYERQDTLK QFLDHDRNVL RFYCFWDDSD
NMFGDPRELI LHYFLADDTI EIREVIHPNS GRDAAPKFLR RSKLPKSSVC SHQPGEITDR
TVLNVFGPMG QGGRYILDSL KTGAMAQQFY KDSDLTLGGV MNVWGRRVII CDCDNFTKEY
YRSKYGIEDF SPVQYKAPLT PEPPRPVPPY NGFGSEEDSL CSCQGLLPKP PQKDFRKLME
KDRQGLESNV LRFMGKMVTD NPIDAERVFI ISFHLSDDTI SVFQPPQRNS GVLGGRFLER
GRVKKPGQEL FKSEMSQYFS AQDLYVGARI TLNNQDFQLL DADEYVFNYM ERHSDEFPRA
NIGSILSKIR SLPEDKHKEI KQFLDLSDPG NTGLIPYEPF RGLLVGLECG LSEHEVMTLG
RCYCERRQPE EDVGLMLAVT QDHLRKKHFE SFSDMSRAFA HQDQPKTGRL STKEVRTICK
AFQLPLPDDL LRALIHKFAA GSEDLDYHAF LAGINWRVDP TPPILPDDVL KFDLDGSREA
RGPEVKDVNC SVLLEDVFGS VGTNTNLTL
//
