ID A0A3P9ALW9_ESOLU Unreviewed; 5729 AA.
AC A0A3P9ALW9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Microtubule actin crosslinking factor 1 {ECO:0000313|Ensembl:ENSELUP00000041700.2};
GN Name=MACF1 {ECO:0000313|Ensembl:ENSELUP00000041700.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000041700.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000041700.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000041700.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR STRING; 8010.ENSELUP00000041700; -.
DR Ensembl; ENSELUT00000042859.2; ENSELUP00000041700.2; ENSELUG00000022868.2.
DR GeneTree; ENSGT00940000155824; -.
DR OMA; SDFINME; -.
DR Proteomes; UP000265140; LG10.
DR Bgee; ENSELUG00000022868; Expressed in heart and 14 other cell types or tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd21188; CH_PLEC-like_rpt1; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 15.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 32.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF25; MICROTUBULE-ACTIN CROSS-LINKING FACTOR 1, ISOFORMS 1/2/3/5; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF02187; GAS2; 1.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF00435; Spectrin; 18.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00150; SPEC; 33.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 27.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51460; GAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 86..189
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 202..306
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 857..914
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 5345..5380
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 5381..5416
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 5421..5499
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1496..1515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1772..1824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1972..1996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2644..2669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5244..5287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5523..5729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 711..738
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1004..1062
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1147..1174
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1385..1415
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1998..2073
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2448..2475
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2702..2729
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2851..2899
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3180..3242
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1499..1515
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1785..1824
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1977..1996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5266..5287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5534..5578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5616..5645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5667..5698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5713..5729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5729 AA; 646561 MW; 9349D49EBEAE4C1E CRC64;
MESSDDDTLS ERSCFSEKSE RSLRSERSGG SLSPSTSAPQ CPPGDTLPWN RPSRHERGER
RKRKTHDSVL DPAERAVVRV ADERDRVQKK TFTKWVNKHL IKVRKHITDL YEDLRDGHNL
ISLLEVLSGV TLPREKGRMR FHRLQNVQIA LDFLKQRQVK LVNIRNDDIT DGNPKLTLGL
IWTIILHFQI SEIYVSGESG DLTAKEKLLL WSQKATEGYP GLRCTNFSSS WSDGRMFNAL
IHLYRPDLID MEAVSRQSNR DNLEQAFEIA ESLGVTRLLD AEDVDVPSPD EKSVITYVSS
IYDAFPKIPE GGEGIAAHEV DHRWAEYQSR FSSLLQWSRQ HTALMANKHF PQNPVELKAL
YNEYVHFKET EIPAKEMEKS RVEHLYKVLE VWMEFGRIKL PQGLHPNDLE DEWGKLILEM
LEREKALRPA VERLESLLQM ANKIQNMALD CEEKLTLARN TLQAVSHAPF VCLPSCHSVR
QNFSLLHRVS CIQDELVSLR LQCSSVYRKG HFSPATGADR TASRGSDGGH CLSTGAQTLL
GAVGAVGLMG ATLLRRPMSR SQLVAMSSSE DEGSLRFIYE LLGWVEETQD VLKRSEWGAD
LPAVEQNLQE HHQIHTAVEE ILHSLKEARN YQTKVSPNFR SSYSDTLAKL ENQYCKLLEH
SSWRLRCLES LHAFVCRCTE ELIWLNEREE EELAYDWSHN NTNVNAKKEL FAEMRSELDE
KQEVMHSLQE TADRLCQENH PAKQTVEAYS AALQTQWQWV RQLCVCVEQH LRDNTAYFQF
VSDARDCETY LRQLQDTIKR QYTSDKNSRL GKLEDLLQDS MEEKEQLIEY RSSVASLVGR
AKTVVQLRPR STESTLGSTT PIRAICDYRQ IEITIRRGEE CVLEDNSQRT KWKVISPSGN
EAMVPSVCFT VPPPNQEAIE MASRMEQLYQ NVMSLWHQLH VNMKSVVSWH YLQKDIRTVS
SWSLHVVRSQ SPEERDQTLD HLEAHLADFL SDSRESALFS PAERRELERD AHAARQHCQD
LLVNMETVEK DESVSRAYLS ELHNIKLRLE EAEQRLVRCI QTPPPSNLSG DRVDNTVQIV
EQEKLQSDLD GLRTSLGEVS RRCVTFFEER PTSSNVPVLR SELNLAVEKV DRLHNLSSVY
LQKLKSVEAL MHCLQAAESQ VKRYECRLSE EDIVPADTGA IQTLSEQLRK WQVELGNQEG
VFQSLRSELQ KAQEAGTQLG RFHPDRSPEL ERYQERADQL TERWSGVKRQ TDLDALGSVL
QLYRDGHSDL IQWIEETTKR QENTQPAKTD SKVLSEQLAQ QTALVAEIEK NQTKLDECQT
YSKQYCTSVK DYELQLMTFR AFVESTQKCP VKRRRMHSSS DAITQEFMDL RTRYTALVTL
TTQHVKYISD ALRRLEEEEK EVEEERQQRV GQVSEMLGWV KGLQGRAGAP SAVSEQLAAK
KDEVAEAIRN AQVFLMSKQA SKLSPEERAQ VTSQLEELTA TYSQLCDSST AQLQELEQQQ
AKEEQRKVEG KKGYGTGVKT RAEGEVVSKA KKRSCQLMLM LSSSFHQSSL LRQKCLEHDQ
QIVALLSMVR HIEVRLKQQQ QQSIGRSLIA LDDIIKQTEM LDLELRDLEP QVNKEVDAAG
LLLNPRPQEV PPQLLLALEK DGRSLTRGYE SAREVSEDIL QGLRTHREAH KETLTLERKS
LEGRVAELLT WLKETEEQII GIDEQTLGET LDQLTQRLHL CKELQSSLSA HSGDINTVAF
DIQVFISERA QDLAPEQSRH FLGQLQQLQK GFHRATSQAN AKTDTISAKR EKELERRHRE
KERAEEERER EKERQSARER EVLQQQKAEC SQKLEGLTMW MAGVSSTLAN QRAGAESGDV
NVLQQKHREL KEVQKDLQTR SEAVAEAIRS VEEFLGEHGD SLSPEERANL QGALSHMKAQ
YSSLGDGARS SLAQLDTAIS TTVQQNAQRA KAAEELQETR GKIHSLLEEL TLPSQPGQRG
AGMTVTDHPS SASPELGLQS HSDMLQKELQ QLQAQQAQLT NVSQSARSLL DQPESAVPAE
EKRRLRDQLE RLQNQHQEKL QACQERLRRS EALKDELAKF LQEHGGLGTW LEQSEGELCS
LGEGETDAQG LKGRLEEHKR LAEDVICHKA DLRFVSISGQ KVLDSVQGAL ERVGGSDLAL
EDTKQLVTEK LRDANQRYTA LHSKSSDLGG RLSGLLDRYQ QYQDEAVSLH AWLSTQEQNQ
SMAGPSGESD TQTLQNSLRA VQLLQDELAE RSVQLEKVKR SGRGLASTQE SPTLRAAEIV
STADGLEKRF SSLSESVSER AEQLQTAVAQ SVSVQEGLKG LLTWLDGLQL TPGTNQPTAQ
AVQDALTQNQ KLRQELLSRQ GSVEATRDAV CELLQSSDAS TASGLQVSLD SLTQRYAAAL
AKQAEMEAEL RGLLPKLESF ERLSTDLQGF AQTRLRSLCP AGQPDRSVED YRHTIEEVRA
ELEQEASQLK SFSQLGTDLS QSKALTNTQC LLDNVREVSD DFARLEFNIN ERYSTIQSCE
QSLGQFRSLS GSLLRWLQTT QEQLPLKEPS LNTEALRRRV QQLTDLLNDW ETEGVRVQEL
NKTGSELETV IINITAPQPK TGVPQVNGAG SPGSVNGIHT CKDLTELQVA VAEVNSRYGQ
LGDELKGRRG RQEASLELRQ TASQDTEELS RWLGERENSL HLGQTTPSPS KPEVARAQAQ
ENKALLSELA EHSGKVEELK SALQKLIADN PDSPEADTWR QQLNEIGSRW AKANETAAQR
QAELETCADR LGSFATAASQ LGPWLKEKEL MMSVLGPLSI DPKMLNTQKQ QVQFMLREFE
TRRPQFDQLT QAAEGILSPC GESSPQDAKD LEEVRSELSS ISQQWDDLTQ RLNQRSEHID
QAQGTSERYQ ALLKNLSASA EALGERLDSQ ASLSAQPEAL KIRLQETGEI RSELEQRREE
LGEAERLCRE LSTIVVEPYL REELKKRLES VSEPLRSLEG RAADGLSQLQ AALSSTQQFQ
QMFEELRSWL DNQGGERDSP ADSLPCQPDA LRSLLAQQDE LQRQVASQRG PYELIQAEGA
SLLASLPAGG QEKSALQSRL DTLRQDWDAH NQRITECQNC LKSTLTKAEC FQQHSSKLTP
WVVECEEREA NIQPSLDSAA LDDAVQKAKQ LGLDLERRRP LLEALNTAAD QLLEHCRVGD
EDVRDEKAQL NRRVDRLSEK LQNRVAQLEE LAGRLKEFED GRQAVERRLE AARHQIEVQE
ALGPQACSNK SLERLRSQQE TLHSLQPQVS YLRDLAQGLV QDTPPTAGGN GEGVQKLEQQ
ARDTEREFGE VSEKIEQCCS ALETRLQGVG EVQSSVRDLF SRLADLDDEL DSLSPVGRDS
DSLASQAEAV RAFLARLATL RSELEGHGGD CTAMLRREGS SPDLLALRRE TEALSRQAGK
LSERGQARLG QIEVAAERVG EFYARVAELQ GLLGRAEEGL NVQGVVGTEV ETIKQQLHEF
KAVEREQVDA IQPKLQQVNA VGQGLIQSAA KHTDTQALEH DLDNTNLRWN SLNKRVAERI
AQLQEALLHC GKFQDALEPL LSWLNDTEEL VANQKPPSAE YRVVKAQIQE QKLLQRLLDD
RRATVQMIQA EGERIAATAE TQDRDKIQKQ LESLGERWSK LLEKASARQC QLEELQGLAL
QFHEAVEPLG EWLSATERRL SSAEPMGTQT SKISQQITKH KALQEAVSSR GAEVDRLEAL
GQSLAPLSCT ADRDWLRERI GVVRLGHSEL SDWCQRRAIM LEQALANAQL FGEDEVEVLN
WLAEVGQRLG QVTVQSYQPA VLTQQHKHTL SLNEEIVSRK KQVDQAIKNG QALLKQTTGE
EVLLIQEKLD GIKSRYGEMT AGSSKALRTL EQALQLSTRF ASAHDDLNLW LDEVEAELNV
MEPDATPAYQ DRQKELKCVS AEKRLVLDTV NEVGSALLDL VPWRAREGLD RLVADANQRY
RTVDETITQR VLLVQAAIQR SQQYEEAVDA ELTWAGETER KLSSLGPLSL EPDVTVAQLQ
VQRAFNIDII RHKDTVDQLL NTRDDILETC SDTQRDALMV KTDSLSSCYE AVSQQHQERF
SALEQAQVLV ARFWETQEEL EPWLGETENL IAQLPPPAID TEALRLQQEQ MRLLRESIAE
HKPHIDKLLK IGPQLAELSH QEGATVRQRY SDAEKRYLAI KEEVKGRATA LDEAVSQSSQ
FHDKMDPLLE TLEGAVQRLR SPPPVAAEVE KIREQLAEHK ATGLELDKLL PSFSALCARG
EELISRAAHN DPAAQAVRSR LMRLRSLWDE IRQRAEEREG KLTDVLDLAG KFWADMAALL
STLRDSQDIV KELEDPGVDP SLIKQQIEAA EAIKAETDGL REELEFVRTL GADLIFACGE
TEKPEVKKTI DEMNAAWEGL NRTWRERMER LEDAMTASVQ YQDALQGMFD YLDNAVIKLC
DMSTVGTDLG TVKQQIEELK QYKVEVYQQQ IDMEKLCHQG ELLLKKVADQ TDRDMIQEPL
TELRHLWDNL GDKITHRQHK LEGALLALGQ FQHALSELQS WLSHTHATLD TQRPISSDPK
AIEIELAKHH VLRNDVLSHR STVETVNAAG AELLESSPGD EASHLRDQLD QLNHSWETLL
LKTQERQKLL EAALHQAEGF HGELEEFLQW LRRTESQLSA AKPTGGLPET AREQLQQHLE
LQTQVTQRAE QYNRMLDAGE SMLLSRGGEE GGSGAVTTQT QQNLALLQNK WASLNTKMDD
RRAKLDEAVT LATGFQTSLQ DTINWLTQAE QTLNMAQPPS LILDTVLFQI DEHKVFVNEV
NTHREQVLAL EKAGSQLRFA SLKQDVVLIK NLLLSVQARW DKLVQRSLDR GRHLDEARKR
AKQFHEAWRK LSDWLEEAES RLDSELEISN EPDKIKIQLT KHKEFQKTLG SKQPVYDTTV
RSGRAMRDKA TLPADTQKLD HLLGEVRDKW DTVCGKSVER QHKLEEALLF SGQFAEALQA
LVDWLYRVEP QLAEDLPVHG DLDLVSNLMD SHKAFQKELG KRTSSVQALK RSARELMETG
RDDTAWVKVQ LQELSNRWDT VCALSVTKQT RLQQALKQAE EFRAAVQLLL EWLSEAEQTL
RFRGVLPEEA ETLQTLLHTH RDFMGTVEEK RTDVNRAAGQ GEAILTMCHP DCITTIKHWI
TIIRARFEEV LTWAKQHEQR LETALTELLN NATLLEELLS WLQWAETTLV QRDAETLPQD
IPQLKTLITE HQVFMEEMTR KQPDVDKVTK TYKRKPAEPP SSLAERRGAR TNQQQQQHQQ
QAAMQVAGGN PRLTQLCSRW QQVWLLALDR QRKLNDALDR LEELKEFANF DFDVWRKKYM
RWMNHKKSRV MDFFRRIDKD QDGKITRQEF IDGILASKFP TSRLEMTAVA DIFDRDGDGY
IDYYEFVAAL HPNKDAYRPT TDADKIEDEV TRQVAQCKCA KRFQVEQIGE NKYRFFLGNQ
FGDSQQLRLV RILRSTVMVR VGGGWMALDE FLVKNDPCRA RGRTNLELRE KFILPEGASQ
GLAAFRSRGR RSKPGSRTAS PTRSSSSASH SAHSCASLPS APATPTASSR SSNSRGYAKP
WLAHSKTPMP TKCQSCPEHG HTTPGPEGAA SGTKLKRPTF HSSRGSLTGE NGGATPISTK
PGRTDPKRTP SGASGPASRA GSRAGSRAGS RASSRRGSDA SDASELLETR SACSDTSDTP
RRPGAAKPSK IPTISKKTPS PKTPTSGKK
//