ID A0A3P9ALZ2_ESOLU Unreviewed; 1987 AA.
AC A0A3P9ALZ2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Dedicator of cytokinesis protein 6 {ECO:0000313|Ensembl:ENSELUP00000041684.2};
GN Name=DOCK6 {ECO:0000313|Ensembl:ENSELUP00000041684.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000041684.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000041684.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000041684.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR Ensembl; ENSELUT00000042837.2; ENSELUP00000041684.2; ENSELUG00000022967.2.
DR GeneTree; ENSGT00940000159313; -.
DR OrthoDB; 5480873at2759; -.
DR Proteomes; UP000265140; LG11.
DR Bgee; ENSELUG00000022967; Expressed in spleen and 15 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF65; DEDICATOR OF CYTOKINESIS PROTEIN 6; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 474..640
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1532..1968
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 805..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1144..1163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1987 AA; 225574 MW; 8CFF008D856EF948 CRC64;
MEFPPDDLEL LLQERECTTL EPPLPEEDIL DPRVRDALSV YTDDWLIIQR KYQSYSTTHT
PHNSERQRER QRGLVKQTFE LDEAAVVERQ DDLEEAKRRS VSLDDTPRGS WASSIFDLKS
SSPDALLPSV LEPTAADDMD RRNAEARLQG RHRDLLGLFS PPDEDEAVER CSLPEVPKEH
CGQRIMVKCL SLKFEIEIEP IFGTLALYDV KEKKKISEDF HFDLNSDQMK GLLRPHTPHI
AISTLARSAI FSVTYPSADI FLVIKLEKVL QQGDIGECSE PYMVMKESDS SKHKEKLEKL
RQQAETSCSR LGRFRMPFAW TAIHLLNIVS SVGGLDRSDP DSDSERKGLG TWNERKKKGF
ERMSVGEDMC NFATFRPATL TVTNFFKQEG DRLSNEDLYK FLADMRRPSS VLRRLRPVTA
QLKIDISPAP DAPHYCLSPE LLHVKPYPDL RVRPTKEVLE FPARYVYTPH TSYRNLLYVY
PQSLNFSSRQ GSVRNIAVKV QFMAGEDHSL AMPVIFGKSS CAEFFREAYS PVIYHDKSPE
FYEEVKMKIP ANLTDNHHLL FTFYHISCQP KQNTPLETPV GYTWIPLMQH GRLRTGSFSL
PVSVEKPPPS YSVLTPDVQL PGMKWVDNHK QVFNVEVKAA SSVHTQDPHL DKFFTLCYVL
EEYSFPFRLK DVIITEANVE GELKASMAAL RAALLDTCVR FLHQLLSKLI RLIVHPPVIA
GQIVNLGRAA FEAMSLLVNQ IHKNLEGNQD QHGRNNLLAS YIYYCFHLPT TEPAMPPTGG
ASPPYELPIQ YATLSRATAR PSSLHLSRSK SISNSNPDLA TSPTSPDEEV QRIIGSKPSD
RGCNRMSAFL DSATFCSAPT RQIAKKLLHE ELALQWVVSS SAVREAALQQ AWFFFQLMTK
SMAHHLFMSS RMEVPRRQRF PDRFVDDIAA LVCAVGADIA GRYHKDVELV ERLNSSLAFF
LNDLLSLIDR GFVFNLIRSY YKQIANKLHT AQNPSSLTAL RMDFTRIVCS HEHYVTLNLP
CSTLSPPASP SPSTSSTTSQ GSAFSSMHQD QGVASMFELS VPFRQQHFLS GLLLTELSLI
LEPDGEGVFF LHKKAISAVH SLMCSHDADP RYTDPQVRAH VAQLYLPLIP IIMDTLPQLH
DFTDTSPSRG RHAASVPDDG DPDNGTINQS VAMAIAGSPL FWSTSTAGRQ CSSLSAECSR
TLLVCFLWVL KNADADLLES WVSDLSVLQI NRLLDLLQLS VSCFEYKGKK ALERINSLTF
KKSQDMKARL EEAILGTIGA RQEMVRRCRG TKRSPYGNEN VRWRKNVTHW KQNTDRAEVE
QESVVDGNLA TEASLVVLDT LEIVVKTVLV SELKESVLGG VLRVLLHSMA GSQSALFLQH
CFTTQRALVF KFPEMLFEED TELCADLCLR LLRHCSSSVG SVRSQASASL YLLMRQNFEI
GNNFARVKMQ VTMSLSSLVG TSQNFNEEHL RRSLKTILTY AEEDLELRDS PFPEQVQDLV
FNLHMILTDT VKMKEHQQDP EMLIDLMYRI AKGYQNSPDL RLTWLQNMAG KHSERGNHAE
AAHCLVHSAA LVAEYLNMLE DCRYLPIGCV TFQHISSNVL EESAVSDDIL SPEEEGICAG
KYFSELGLVG LLEQAASSFH MASMYEAINE VYKILLPIHE ANRDFKKLAT VHGKLQDAFN
KVYNQSSGWE RMFGTYFRVG FYGSRFGDLD EQEFVYKEPS ITKLAEISHR LEEFYAERFG
DDVVEIIKDS NHVDKNKLDP NKAYLQITYV EPFFDTYELK ERITYFDKNY NLRAFMYCTP
FTLDGRAHGD LHEQYKRKSI LTTSHAFPYI KTRINVISKE EIILVPMEVA IEDMQKKTQE
LAFATHQEPA DAKMLQMVLQ GSVGTTVNQG PLEVAQVFLS EIPDDPKLYR HHNKLRLCFK
DFTKRCEDAL RKNKTLIGQD QKEYHREMER NYNKLKESLG PLINRKIPQL YRTLPATGPQ
PATLTHR
//