ID A0A3P9AMQ0_ESOLU Unreviewed; 1919 AA.
AC A0A3P9AMQ0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Discs large MAGUK scaffold protein 5 {ECO:0000313|Ensembl:ENSELUP00000042037.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000042037.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000042037.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000042037.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 8010.ENSELUP00000042037; -.
DR Ensembl; ENSELUT00000035736.2; ENSELUP00000042037.2; ENSELUG00000023155.2.
DR GeneTree; ENSGT00940000155303; -.
DR Proteomes; UP000265140; LG06.
DR Bgee; ENSELUG00000023155; Expressed in brain and 15 other cell types or tissues.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR CDD; cd00136; PDZ; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd11860; SH3_DLG5; 1.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR006907; DLG5_N.
DR InterPro; IPR035537; DLG5_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46360; DISKS LARGE HOMOLOG 5; 1.
DR PANTHER; PTHR46360:SF1; DISKS LARGE HOMOLOG 5; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF04822; Takusan; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 4.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 4.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..92
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 623..713
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 708..799
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1357..1436
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1502..1583
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1594..1662
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1739..1905
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 98..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 816..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 981..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1112..1140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1232..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 148..595
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 98..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..873
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1006..1034
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1052..1067
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1232..1274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1291..1332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1919 AA; 214806 MW; 8805FAFA9E0B21B5 CRC64;
MEPKHKELLD QCHQNLLDSI TDADRLIELL ILSGTLSQLD RFELDQNCSS SAEKVDQLLK
MLVNKESDHF PELCVALEKA YPDLYSALFT NGDVVPSSSA GSTYSVLSTM PSDSESSSSL
SSPPGTGNGS ASSPPPALND NRPAGDNLDT ILFQLRQVTR ERDELRKRLA LASPGTTFDD
CRPNSKASHD YERLKSQCMR AMADLQSLQN QHTKTLKRCE EAVKEADFYH MLHSRVLGDQ
SQLKEELELL RRDNTQLVRE HNHLKQSCEE LRRLHSEVQK EVADMRLQQQ EVMRENGSSE
VLNKLYDTAM DKLEGVRKEY DSLSKRYSEK VANHNTDLSR LEQAEEENRR LQKQMDTLLK
QRDTAIHYQQ QCSTSMRRFD SVQQELNKSS AQNKELQREM ERLQSEVTRY KNFQLKAVKD
CEKYKEERDS VFNEYRLIMS ERDQVIKELD KLQTELEAAE ARLKTTSSER VVASEEMEAL
RQKQDSATLD MERANKEIEV LRKQYEAMSQ ELKEATQEAE VAKCRRDWAF QERDKIVAER
ESIRTLCDNL RRERDRAVSD LADALRNLDD MRKQKNDATR ELKELKEKME SQLDKEARFC
QLMAHSSHDS AIDTDSLEWE TEVVEFEKDR DDMDLKALGF DIAEGVNDPY LPGDCGIFVT
RVDKGSVADG RLRVNDWLLK INDMDLANKD RKQVVKAVLN GGGLINMVVR RRKSLGGRLV
TPVHINLIGH KDSGIGLESG VFVTALVQGS PAAREGSLTV GDRLIAINGI ALDNKSVTEC
ETLLRNCRDS LSLSLMKFFP HSSSGQNIFE TLRESSSNGR LSEVHSRNSR NLKHNSSTQT
DIFCPDPSGG SNTHVPGERR KGREGEPEEG MGVYGDVRKP FSTVSLHATS LRPSSDLCLG
LPGRYGPSAF EECCSGSPYA KPPPPPVAYD PSSTPDCITV ETTLEKKHSG GTWPKMIVGG
MSVAVDTTTV TTPTQLSIFK SPKQRKSIFD PDAFKPRPET APPSSKMEFL SPSQLVTHSP
QPSKTDSLSS SSTATPTPPT PPTRSDSFKF KHKQQSSSAS DCTLTSDGNW GKGESVVIVT
AEGHGGRERE QERDRNGNHY FLDGKVLTSR KSCDEDIGRT RGEEPEVKRP RPKSAPALRR
RMTPQSITLP SFQVSWTTMW MYPMLALTPV PCALSGSAHR GLAPCPAVTA VMRNPVYTVR
SHRVHTNNCP SVASQICHPQ HQGRLSLDLS QKHPTADYSE SSSSRGNHAS HGTNSLPSSA
RLGSSSNVQY RTERIKIPST PRYPRSMLGS DRGSLSHSEC SSPGLITPPQ SPLNLETSSF
ASSQSQSSIS TLPRISVSPV PIGERRKDRP YLEEPRNVIV HKGAEPLGIS IVSGENGGIF
VSKVTGGSIA HQAGLEYGDQ LLEYNGINLR NATEQQARLI IGQQCDAITI MAQYNPHMYQ
LGNHSRSSSS VKLTPEHFLT VSVSTPVVII GITGPILFPL KMSLLLMTFL YVGGGRVCEP
RVVTVRRAQG AELGLGLCGG NLWGVYVESL EKDSPARGAE GLLPGDLIIE YGSVNMKNKT
VEEVYVEMLK PAETVTLRVQ QRPDDFNMVK DTPGDGFYIR ALYERTAEAE PDLSFKKDDI
LYVDDTLPKG NFGTWMAWQL DENARRIQRG QIPSKYMMDQ EFYRRHSMTE LKDDKDSKSL
SAAARRSFFR RKHKHKRSSS RDGKELVALD AISTDSIPFL EDCVSLAYQR VQKVECGSPR
PVLILGPLTD PVKDMLVKES PGKFCRCVLE VMKASQQAIE RGVKDCLFID YKRRSGHFDV
TTVASIKEIT EKDCHCLLDI APHAIERLHS VHIYPIVVFI RYKNAKQIKE QKDPVYLRDK
VSQKHSKEQF EVAQKIEQEY SKFFTGIVQG GTLPYICTQI MTIVDQEQSK VLWTPLGCP
//
