ID A0A3P9AP36_ESOLU Unreviewed; 424 AA.
AC A0A3P9AP36;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=NAD kinase 2, mitochondrial {ECO:0000256|PIRNR:PIRNR017565};
DE EC=2.7.1.23 {ECO:0000256|PIRNR:PIRNR017565};
DE AltName: Full=NAD kinase domain-containing protein 1, mitochondrial {ECO:0000256|PIRNR:PIRNR017565};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000042495.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000042495.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000042495.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to
CC yield NADP(+). Can use both ATP or inorganic polyphosphate as the
CC phosphoryl donor. {ECO:0000256|PIRNR:PIRNR017565}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + NAD(+) = ADP + H(+) + NADP(+); Xref=Rhea:RHEA:18629,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:58349, ChEBI:CHEBI:456216; EC=2.7.1.23;
CC Evidence={ECO:0000256|PIRNR:PIRNR017565};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR017565}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|PIRNR:PIRNR017565}.
CC -!- SIMILARITY: Belongs to the NAD kinase family.
CC {ECO:0000256|ARBA:ARBA00010995, ECO:0000256|PIRNR:PIRNR017565}.
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DR RefSeq; XP_010893991.1; XM_010895689.3.
DR AlphaFoldDB; A0A3P9AP36; -.
DR Ensembl; ENSELUT00000036624.2; ENSELUP00000042495.1; ENSELUG00000023791.2.
DR GeneID; 105025172; -.
DR KEGG; els:105025172; -.
DR GeneTree; ENSGT00390000006320; -.
DR InParanoid; A0A3P9AP36; -.
DR OMA; LAGDFRW; -.
DR OrthoDB; 231143at2759; -.
DR Proteomes; UP000265140; LG14.
DR Bgee; ENSELUG00000023791; Expressed in heart and 15 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003951; F:NAD+ kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019674; P:NAD metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006741; P:NADP biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR017437; ATP-NAD_kinase_PpnK-typ_C.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR InterPro; IPR002504; NADK.
DR InterPro; IPR012355; NADK2_mit.
DR PANTHER; PTHR13158; -; 1.
DR PANTHER; PTHR13158:SF5; NAD KINASE 2, MITOCHONDRIAL; 1.
DR Pfam; PF01513; NAD_kinase; 1.
DR PIRSF; PIRSF017565; Kin_ATP-NAD_euk; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR017565};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR017565};
KW Mitochondrion {ECO:0000256|PIRNR:PIRNR017565};
KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|PIRNR:PIRNR017565};
KW NADP {ECO:0000256|ARBA:ARBA00022857, ECO:0000256|PIRNR:PIRNR017565};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR017565};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR017565}.
SQ SEQUENCE 424 AA; 48308 MW; FB1DAB2CD9CCBA91 CRC64;
MTHRSFTNLL YLGKRAFTIL NRRSSRLPHV LMGAQHIASQ AESGFKPSKV AVVTKMTRYE
FEQQRYRFSE LSEEDLKQLL ALKGSSYLGL LERHNIHTRN VEHIVESLLK EGIEVRLVKR
GEYDEETVLW ADAIISAGGD GTMLLVASKV FNKDQPVLGV NTDPERSEGH LCLPVRYTRA
FPEAIQKLCR GQFRWQWRQR IRLHLEGTGI NPTPVDLHEQ QLSLEQHNQA HRITLMEAQR
SEVDSLSKPY LLPVRGLNEI FIGESLSSRA SYYEISVDDG PWEKQKSSGL SICTGTGSKA
WSYNINKLVE QAVEEVLWIG KAKTGLEIPV TQDLIEKVTD EYNRSLVFGP EESRMFFSIR
EPIVNRVFSS SRQRGFANRV CVRSRCWDAC MVVDGGTSFE FNDGAIATIT MNEEDQLRTV
LLEN
//