ID A0A3P9AQ99_ESOLU Unreviewed; 202 AA.
AC A0A3P9AQ99;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Troponin I, slow skeletal muscle {ECO:0000313|Ensembl:ENSELUP00000042932.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000042932.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000042932.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000042932.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin
CC filament regulatory complex which confers calcium-sensitivity to
CC striated muscle actomyosin ATPase activity.
CC {ECO:0000256|ARBA:ARBA00001988}.
CC -!- SIMILARITY: Belongs to the troponin I family.
CC {ECO:0000256|ARBA:ARBA00009930}.
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DR RefSeq; XP_010885632.1; XM_010887330.3.
DR AlphaFoldDB; A0A3P9AQ99; -.
DR Ensembl; ENSELUT00000037441.2; ENSELUP00000042932.1; ENSELUG00000024367.2.
DR GeneID; 105020362; -.
DR KEGG; els:105020362; -.
DR GeneTree; ENSGT01030000234588; -.
DR InParanoid; A0A3P9AQ99; -.
DR OMA; YEDMFAR; -.
DR OrthoDB; 2882372at2759; -.
DR Proteomes; UP000265140; LG23.
DR Bgee; ENSELUG00000024367; Expressed in heart and 9 other cell types or tissues.
DR GO; GO:0005861; C:troponin complex; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.350; -; 1.
DR Gene3D; 6.10.250.180; -; 1.
DR InterPro; IPR001978; Troponin.
DR InterPro; IPR038077; Troponin_sf.
DR PANTHER; PTHR13738:SF38; NOVEL PROTEIN (ZGC:92233)-RELATED; 1.
DR PANTHER; PTHR13738; TROPONIN I; 1.
DR Pfam; PF00992; Troponin; 1.
DR SUPFAM; SSF90250; Troponin coil-coiled subunits; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 27..93
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 202 AA; 23214 MW; 4179E8DE638A4AB0 CRC64;
MSTKEQDPSR RVNPKLIDKP KSKITASRKL SLKIMLLTRA MEQLEQEKQD RDEEKERYLG
ERLPPLQLSG LSLADLQDLC RQLHAKIEVV DEERYDCEAK VNKHNKDIHE LKLKVQDLGG
KFKKPALRKV RVSADEMMRA LLGTKHKGSM DLRSNLKSVK KEDTNKDKDK VLTAEVTDWR
KNVEAMSGME GRKKMFDASG GQ
//
