ID A0A3P9AS26_9CICH Unreviewed; 1103 AA.
AC A0A3P9AS26;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Insulin receptor substrate 2 {ECO:0000313|Ensembl:ENSMZEP00005000202.1};
GN Name=IRS2 {ECO:0000313|Ensembl:ENSMZEP00005000202.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005000202.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005000202.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005000202.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9AS26; -.
DR STRING; 106582.ENSMZEP00005000202; -.
DR Ensembl; ENSMZET00005000258.1; ENSMZEP00005000202.1; ENSMZEG00005000269.1.
DR GeneTree; ENSGT00940000161407; -.
DR OrthoDB; 4212441at2759; -.
DR Proteomes; UP000265160; LG16.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR CDD; cd01257; PH_IRS; 1.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF7; INSULIN RECEPTOR SUBSTRATE 2; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 20..121
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 155..259
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 259..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1024
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1103 AA; 119614 MW; 2C815FAC5E9560D8 CRC64;
MASPPNTGDQ SLLASNANSG IKKCGYLKKQ KHGHKRFFVL KEPSEGFPAR LEYYESEKKW
KNKSAPKRVI PLDCCLNISK RADAKYKYLI ALYTKDEYFA LATENEQEQE SWYRVLTDLM
AEGKVYDGSA SNSASSLVGY DESSYGVITP VTAAYKEVWQ VNLKSKGLGQ SRNLTGVYRL
CLSSRTISFV KLNSDVASVT LQLMNIRRCG HSDSFFFIEV GRSASTGPGE LWMQADDSVV
AQNIHETILE AMKAMKELSE FRPRSKSQSS GTNPISVPSR RHLNNLPPRQ TGLPRRSRTD
SMAATSPVSK CSSCRLRTAS EGDGTMARTM SVTGSPLSPG VHRTLLSRSH TITARPSLTF
ESSTLQHSKS MSMPLSPSPP VTTACPSHAS SCQDSGAPRP SSCSASFSGS PSDAGFISCE
EFGSSPAEAR DLRLPLTLRS NTPESLKADT PPSRDGSELD GYMVMERQNQ NGYRWLPEFD
KVYRKRTYSL TTPRQPRGPP QVSSASLDEY TLMRATYTSG SQSSRRCHTA SPKGISLEDY
RDVQIASNGH QGDSGYMPMM PGVAPLTPGS KDDPYMPMSP MCVSAPKQII NPCTKPSSMG
LATRIHSPGG VSLEDSGYMP MWCATKMSVD SNDGKLANGE YLNMSPVDTQ VSFTPPDYIL
SPTGDPSLPP SHRQPYSCSS LPRSLKGHLQ RSGSTDTDQY VVMSLQRQRI EEESNYCPIS
SGNSATNGTV ARPATPSSTP SPLRVAWIDG GLVHRSRVCR PTRLALESLK TLPCMSEHPL
PSEPRSPGEY INIDFSSVNH NTTTESKSPE SSVTAETGSR SLSGYANIDV SSTVQQVSHQ
TNCTDTAELL TCHSLVTTQQ ETQGVEEEEV EEDKSTEGQE KERGVPQQGS LKCQPGPFSD
DYTEMTFSPS DPLPALCTTP RPTSPTACVQ RLSLESSIVD VMPPVPVDSF LKGGPSLSVT
VVDPHRGAKV IRADPHGRRR HSSETFSSTT TVTPVCPSFA NDTKRHSSAS VENVSRTVRS
SEGLGEEYSS PMCRETSAGY QNGLNYIALN LMEGNLGGCR LGGCDELLRL KTACGCKGGL
NGFNSSPYAS LGFKETAAAA VKE
//
