ID A0A3P9ASM8_9CICH Unreviewed; 1107 AA.
AC A0A3P9ASM8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=DExH-box helicase 29 {ECO:0000313|Ensembl:ENSMZEP00005000725.1};
GN Name=DHX29 {ECO:0000313|Ensembl:ENSMZEP00005000725.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005000725.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005000725.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005000725.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9ASM8; -.
DR Ensembl; ENSMZET00005000798.1; ENSMZEP00005000725.1; ENSMZEG00005000550.1.
DR GeneTree; ENSGT00940000157286; -.
DR Proteomes; UP000265160; LG7.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF145; ATP-DEPENDENT RNA HELICASE DHX29; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 385..492
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 589..764
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1107 AA; 125571 MW; 90773F78380B48B9 CRC64;
MGGKKKKSPP QASAPAAPGN GVVEEPRKQA ATSKPAKDSK SKGENHSQRE HFTPRLRRLH
CIFTPINKIL VAIQADLEKK IIKLINEFRQ ENGDKGPISG RLTSKKLLDL YTALQKFNFK
REHIEEAMKS SILYGGDLHS ALDWLCLNLK DEELPDGFSQ QMQEESQKNR PRFQPPVQQK
PAAQDPKVSN NTTRREITKV CTERVMKDWI LRYAEQSSEE EEEEGGKKTC NPELEEKFDP
VSTIRQLESH PMFNPAIKVV DAPQKEKKIL PAKEDKEELG FSLFEQAEKD PPAEKVVKKN
EPKDIRNFDY TARSWTGKSP KQFLIDWVRK NLPKSPPPAF HKVACGRYWR CKVRVQRPDD
VLEVCPTILT EDSMQAQHLG ATLALYNLVK GQSSLCGYQI RMENQSGDWT RLLYCTTGVL
LRKLQHDRHL TSLTHIIVDE VHERSVQSDF LLTILKDVVM KRSDLQLILM SATVDCDKFS
NYFNRCPVIS IPGRTFPVEV FHLEDIVEQT GYVLEKDSEY SQKILEEEEE VTISVTQKGG
KTLQHQEVIV RDSSSGWDLG PDLDHFSSRT RHVLQYMNPN KVNMDLLVDL IDYLDKAPQF
VDVDGAILVF LPGLAHIQQL FDLLSSDKRF RDKTRYRIVA LHSTLSSKDQ AAAFTVPPSG
VRKIVLSTNI AETGVTIPDV VFVIDTGKTK ENKYHESSQM SSLVETFISK ASALQRQGRA
GRVRNGFCFR LYPKYRFDIF MDYSIPEILR VPLEELCLHI MKCQYGSPED FLSRALDAPQ
PQSVSNAVNL LRKIGACHPD DHILTPLGHH LASLPVNVKI GKMLIYGAIL GCLEPIAIIA
AAITEKSPFF TPMNRKEEAN LAKAALAIAN SDHLTIYNAY LGWKNSQTDG SRGEMSYCRK
HFLNRTALIT IEDVKRELMK MMEQVGFWSS RSSSSSSLKP QAASMSKQQI SVLNAVLTAG
LYDNVARVLC TPSVDVLERV ACTVETPQGK AQVHFSSVNR NLQTHGWLLY QEKVKYTKIY
LRDTTLISPF PMLLFGGDID VQHRERLITL DGWIHFQAPV RIGVIFKHLR RLMDSLLERK
LENPRMNLEG EATIRIILDL IKSEYAA
//
