ID   A0A3P9AT54_9CICH        Unreviewed;       105 AA.
AC   A0A3P9AT54;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Luteinizing hormone subunit beta {ECO:0000313|Ensembl:ENSMZEP00005000861.1};
OS   Maylandia zebra (zebra mbuna).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX   NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005000861.1, ECO:0000313|Proteomes:UP000265160};
RN   [1] {ECO:0000313|Ensembl:ENSMZEP00005000861.1, ECO:0000313|Proteomes:UP000265160}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA   Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA   Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA   Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA   Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA   Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA   Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA   Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA   Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA   Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA   Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA   Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid fish.";
RL   Nature 513:375-381(2014).
RN   [2] {ECO:0000313|Ensembl:ENSMZEP00005000861.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC       {ECO:0000256|ARBA:ARBA00003920}.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC       {ECO:0000256|ARBA:ARBA00011870}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|RuleBase:RU004069}.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000256|ARBA:ARBA00006552, ECO:0000256|RuleBase:RU004069}.
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DR   AlphaFoldDB; A0A3P9AT54; -.
DR   STRING; 106582.ENSMZEP00005000861; -.
DR   Ensembl; ENSMZET00005000937.1; ENSMZEP00005000861.1; ENSMZEG00005000770.1.
DR   GeneTree; ENSGT00940000161285; -.
DR   Proteomes; UP000265160; LG12.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; GLYCOPROTEIN HORMONE BETA CHAIN; 1.
DR   PANTHER; PTHR11515:SF11; LUTROPIN SUBUNIT BETA; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   3: Inferred from homology;
KW   Hormone {ECO:0000256|ARBA:ARBA00022702, ECO:0000256|RuleBase:RU004069};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          7..97
FT                   /note="Glycoprotein hormone subunit beta"
FT                   /evidence="ECO:0000259|Pfam:PF00007"
SQ   SEQUENCE   105 AA;  12037 MW;  908C35552DE65E3A CRC64;
     QRCYKKISCK KNHTVFKTGC VSPHIHSPDP VIKIPFSNVY QHVCTYRDLY YKTFELPACP
     PGVDPIVTYP VALSCHCGRC AMDTSDCTFE SLQPDFCMND IPFYY
//