ID A0A3P9AVD2_9CICH Unreviewed; 202 AA.
AC A0A3P9AVD2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial {ECO:0000256|ARBA:ARBA00020530};
DE AltName: Full=Complex I-ASHI {ECO:0000256|ARBA:ARBA00032752};
DE AltName: Full=NADH-ubiquinone oxidoreductase ASHI subunit {ECO:0000256|ARBA:ARBA00032699};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005001377.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005001377.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005001377.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000256|ARBA:ARBA00011533}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00004298}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004298}; Matrix side
CC {ECO:0000256|ARBA:ARBA00004298}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB8 subunit family.
CC {ECO:0000256|ARBA:ARBA00008039}.
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DR AlphaFoldDB; A0A3P9AVD2; -.
DR STRING; 106582.ENSMZEP00005001377; -.
DR Ensembl; ENSMZET00005001468.1; ENSMZEP00005001377.1; ENSMZEG00005001150.1.
DR GeneTree; ENSGT00390000000628; -.
DR Proteomes; UP000265160; LG8.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:InterPro.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR InterPro; IPR008699; NDUFB8.
DR InterPro; IPR016551; Ndufb8_metazoa.
DR PANTHER; PTHR12840:SF1; NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12840; NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT; 1.
DR Pfam; PF05821; NDUF_B8; 1.
DR PIRSF; PIRSF009288; NDUB8; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
SQ SEQUENCE 202 AA; 23378 MW; DBC05F84805623DC CRC64;
MRTSEYVEQQ QPVNMAGVGF RRWAQALSKG KGSGISALLS GCRAASGLSK DSLPGPYPKT
PEERAAAAKK YNMRVEDYEP YPDNGEGFGD YPKLPERSQQ ERDPWYQWDH PDLRRNWGEP
MHWDFDMYIR NRVDTSPSPV PWSTMCKQLF GFIGFMLFMF YVGEKFPAYQ PVAPKQYPFN
DLYLEKGGDP EKQPEEVKHY EL
//
