ID A0A3P9AWC8_9CICH Unreviewed; 891 AA.
AC A0A3P9AWC8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005002001.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005002001.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005002001.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR RefSeq; XP_004562928.1; XM_004562871.2.
DR AlphaFoldDB; A0A3P9AWC8; -.
DR Ensembl; ENSMZET00005002100.1; ENSMZEP00005002001.1; ENSMZEG00005001552.1.
DR GeneID; 101485211; -.
DR GeneTree; ENSGT00940000157439; -.
DR OrthoDB; 960at2759; -.
DR Proteomes; UP000265160; LG4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972:SF146; OXYSTEROL-BINDING PROTEIN; 1.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 84..179
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 15..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 891 AA; 100678 MW; 785FBB773720C556 CRC64;
MQRYSHYIAP MDPQVCPPPL SSSQSVISGL DKSPASTFRP GHSRSSSTGS GKHSKQSRHW
EVVDDLQHAD RGLVPGSSGD LSIPGICEGY LMKRRKYPLK GWHKRYFLLE KGILKYSKTQ
QDIQRGKLHG SLDISMAVMS VNKKTKRIDL DAGDNLYHLK AKSHDIFYIW LTKLCAHRVF
RKNEAMSVHR GVLHALSLGQ STLPAFSQQS RATIPHYASS ASVYHPEMAS PAPAVASQPG
VTSKVSAWLQ QTHDIDATSN ELARCQADLT ELAQLIQRLN WLEGGYPITN TDLEMRISMQ
NLSLEKPKKK NGRMPGHSRT LSRAEAMGGM QFTSSHLSTN STSVQSIPNY VYSQLSNPQV
TSPEAKKLHQ EICTASQRVH SSLKSIHEVL TLERERLRQA WTGPDMRQNT SQQLATICST
LSERTPSLSR HSNRPPSVAD SMAEYFDASE VIVCETSSEA EASDESGLSD ITTTSTSEPE
EGHSAATLNY RESLNSASHK PRPVPPDTGR RTTLPAPCAD NSHIGIMTIL YNNIGKDLSR
VSMPVALNEP LSLLQRLSEE LEYSELLDIA SNIDDPYERM VYVAAFSISG YAWASWRNRY
KPFNPVLGET YENYREDKGF QYISEQVSHH PPISACHAES ENFTFWQDQR WKYKFWGKSV
EIISSGLVNV TLPSYGDHYE WNKAVTCIHN VLSQQRSLEH YGEVTIRNTK SDVCTCKITF
VKSRYWSSDS SKNEVQGVVL DQAGSVIHRF GGLWHEGIFC DTLPTPKCIW KPNVQPDDYV
KFYGFSSYAR ELNELTSELK AVLPPTDTRF RPDQRLLEEG KIAEADKRKD EVEENQRERR
KEMAKKGEEH IPRFFRKSVD EAGREVWLYN GTYWMLRKDP GFANTENLDL W
//
