ID A0A3P9AXQ2_9CICH Unreviewed; 2906 AA.
AC A0A3P9AXQ2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Bromodomain PHD finger transcription factor {ECO:0000313|Ensembl:ENSMZEP00005002217.1};
GN Name=BPTF {ECO:0000313|Ensembl:ENSMZEP00005002217.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005002217.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005002217.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005002217.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSMZET00005002318.1; ENSMZEP00005002217.1; ENSMZEG00005001750.1.
DR GeneTree; ENSGT00940000154830; -.
DR Proteomes; UP000265160; LG6.
DR GO; GO:0016589; C:NURF complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd05509; Bromo_gcn5_like; 1.
DR CDD; cd15559; PHD1_BPTF; 1.
DR CDD; cd15560; PHD2_3_BPTF; 2.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR038028; BPTF.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001510; Znf_PARP.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45975; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR PANTHER; PTHR45975:SF2; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF00628; PHD; 3.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00249; PHD; 3.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50064; ZF_PARP_2; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 227..287
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 377..424
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2712..2814
FT /note="PARP-type"
FT /evidence="ECO:0000259|PROSITE:PS50064"
FT DOMAIN 2721..2788
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2814..2884
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1021..1118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1154..1317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1351..1428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1524..1544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1562..1584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1652..1699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1868..1898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1929..1957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2173..2199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2291..2365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2622..2670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2435..2470
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2525..2552
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2576..2613
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 30..44
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..173
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..624
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1050
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1051..1085
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1094..1108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1165..1182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1253..1317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1351..1365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1384..1400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1525..1544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2291..2320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2327..2365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2622..2639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2642..2670
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2906 AA; 319540 MW; E28D2F71723AF75B CRC64;
MRGRRGRPPK QAAVMREGSP GPVRGSRGGR SRGMRGRGRG RGRGRGRGAS GGVCGTGSVE
VDTEISGREN FHSSRGRRKV GASTTAATAA SRGRGGRGRG RGSRGGRGSR GGVRRPQTKV
VYDDNSDEED DNLSYRSDED ELLNDNPSSD LEEEEALGND SDYVEELPDD DDASYCTESS
FRSHSTLGST PGRKKTRTLQ PRSPIHEAKD IPSLELPKSS EDLLVPTSQL LNVSAVYEVL
RNFGTVLRLS PFRFEDFCAA LASQEQCTLL AETHVSLLKA ILREEDTSNT TFGPTDVKDS
VNSTLYFVDG MTWPEVVRAY CESDPEYRHI LPFQENEDYP YGPLDSKIKV LQFLVDQFLA
TNIAREELMS EGVVAYDDHC RVCHRLGDLL CCETCSAVYH LECVKPPLQE VPEDEWQCEV
CVAHKVPGVA DSIPEVQKSR PFIRQLPIGY DRHHRKYWFL NRRVIVEEDG ELEDKAIWYY
STKVQLAELI DSLDKEYWEA DLYAALQEIR DEVHTHMDIT EDLTNKARGS NKCFLTAANE
EILERLRAKK EEELEEVKRR AAEEALKAQM EKEKREVDVE KEDEDVKLKD EGQQEAKIKE
AAKEEGEQRT KEEEATKKKV DGAKAGAENP PSNSVPVSGD GIPSLSQPPH PIEENSNSST
GAGVPPRCPE PPDLADKSSQ SSLASLDDAG DGKDSTNGEG TGPGAKKSSA TRMVTRLRNP
DSKLSQLKNQ QVAAAVHEAN KGFKEGREVL VVNAQGDITR VSTRSSKDVV MKGTLSQYFK
LGQEGKYRIY HNQYSSNALA LNKHQHREDH DKRRHLSHKF CMTPAGEFKW NGSIYGSKVL
TISTLRLTII QLENNVPAPF MHPNWASHRT NWIKAVQMCS KAREFALALA ILECAIKPVA
MLPIWKDSLG HTRLNRMTSM EREEKEKVKK REKKLEDEET LQQATWVKYT FPIKHQVWKQ
KGEEYRVTGY GGWSWISKTY VPRFVPRLPG NTNANYRKEL EDAKLGKKCT LLDLSRRPSV
VTPEAQGAVA TSSEATEEDS SGLPKPLTDQ QTSNEKRDEE KKEDLDEKEK AKEELPTKME
VDSTDSPSDE VQSSCIQEDK DSLKEEPTES LQRPFNYDVV DVSKGFLTRI AYKKKVKSSK
LDSLLERRVK QHIIEERQRE QVSASKPQEP KQVSSTPTPA LSTPVRPRSP LKPQALTQTH
LTLGEAVKVE EKPSTTETPG QGEVGGQKVE GESRDELSKT TDKIVTPLPS PVIDSTPKDS
SSTGENSNSP QHQTTSSPQK LVENERTTGP KEASSGQEVV KLPNVQETTA SSLEQQADCV
ASDVTKAALT ENEGSEEPKL KLNAAVTFRS GLDQKDSQDT APLKPIPQNT EVLGSVHLST
EENGMGPEDS QDNMQDIGDG RTVTGTPEPL SPLPQVNGND GFGGENMLGN SVVSSNNGML
NNRPQPKVNS IGKDEDEQRL AVSLKDTTQQ KPLVNGDLAS LNTSTEVRVK ENCLASKVEA
ESKITNSDQD YKPPLKKTKL ENNVDTPAEH TPNVHNSTSS FECTETKPSL GVKIIRMAPS
PIPSAEESSL SDDFAEENGS GGATEPVKTI ITQVTTTSTT TTTTVLSTEM RIAKVPSTTS
GEPVVPVVST TESSAVSTLT TMTKTTVTKI LSPGLDGQSE DSQSEMVTQE QKTTLLASVG
ESTTDASGKT SVSSVTVSEE DSSTKGRVRL LKFSRTKKTR SDTALPSYCK FVTKSSRKSI
FVLPHDDLKI LARRGGFREV PVFSYNAKPA LDIWPYPSPR PTFGITWRYR LQTVKSMAGV
SLMLRLLWAC LRWDDMAVKP SAAVGTTRTE TSDTEITTTE IIKRRDVGPY GIRSEYCIRK
IICPLGVPET PKETHTPQRK GLRSSALRPK KPEPAKQTGP VVIETWVAEE ELDLWEIRAF
SERVEKEKAQ AAEQAKKRLE QKPGSVTTPA GSPATPAATP KVIVGSLSGQ GTPGTKVVLS
TKMGTPVTFQ QNKNFQQSFA TWVKQGQSTQ GAGSETTVAT SGGHTFQITG TSVGGKVVTT
KLPLPANSKI VTVNVPTSQG GVVQQKVLGI IPSSTAGGAQ TYTTFQPRTT TLNIRPNTAG
SQQQVLAGGS QIRPGMTMIR TPVQQTGPMG KTILRTPLVV QQGQGGQQVV TQIIRGQAVS
TAISAASPVA TVTGQGVASP NTAGQAAGQT PPGTPRAQGQ GQVKLTLAQL TQLTQKQQAG
SGVDRQAGAS GTQQALTVMV QGQGQTTGQL QVIPHGVTVI PGPGQQLMQA ALPNGQVQRF
LFTPLASAAT PTSSTATTAT SQPSSTSTKT PAQPAQQAAA PIQTGAAPLA TASTPSSASP
QGQLPPQTQA HMPIQSPTSL QVKTQEGTTQ LQLQQTSHVI SVSGLQQQVL AQLQAQQVGG
TLPQQIKLQL PIQIQQSGTT SAQGGQIGNV VTIQAASVQE QLQRIQQLRE QQQQKKKQAA
EAKRELALNA ASQSDIIQKQ VVMKQNAVIE HLKQKKTMTP AEREENQRMI VCNQVMKFIL
DRIDKDERQA AKRRKKEEVV EAKRRLANAS KLSSLLYRHK ESLKMEILKK RALLDKELQL
EAQEELKRDL LRMRREKERA QAAAQQAAQA AAAAAVAAAH NQQQKNMSHI TSQHHLSTTV
SSAHKRKREE EREMTTSAKS KKKKMISTTS TKESKKDTKL YCICKTPYDE TKFYIGCDLC
TNWYHGECVG ITEKEAKKMD DYICVECKRG QESSTEELYC ICQTPYDESQ FYIGCDRCQN
WYHGRCVGIL QSEANHIDEY VCPQCQSTED AMTVFTPLTD KDYDGLRRIL RSLQAHKMAW
PFLEPVDTND APDYYRVIKE PMDLSTMEER LQKREYIKLT EFVADMTKIF DNCRYYNPSD
SPFYQCAEVL ENFFVQKLKG FKASRL
//