ID A0A3P9B0E5_9CICH Unreviewed; 765 AA.
AC A0A3P9B0E5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Semaphorin 3C {ECO:0000313|Ensembl:ENSMZEP00005003410.1};
GN Name=SEMA3C {ECO:0000313|Ensembl:ENSMZEP00005003410.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005003410.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005003410.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005003410.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR RefSeq; XP_004548444.1; XM_004548387.1.
DR AlphaFoldDB; A0A3P9B0E5; -.
DR STRING; 106582.ENSMZEP00005003410; -.
DR Ensembl; ENSMZET00005003542.1; ENSMZEP00005003410.1; ENSMZEG00005002601.1.
DR GeneID; 101486867; -.
DR KEGG; mze:101486867; -.
DR CTD; 10512; -.
DR GeneTree; ENSGT00940000159379; -.
DR OrthoDB; 5342713at2759; -.
DR Proteomes; UP000265160; LG17.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR CDD; cd05871; Ig_Sema3; 1.
DR CDD; cd11251; Sema_3C; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF25; SEMAPHORIN-3C; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..765
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018121923"
FT DOMAIN 39..522
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 601..666
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 722..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..765
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 765 AA; 86514 MW; 4849194C6FE5912F CRC64;
MGRPEGLARP PLVSAMAFSF LALSFLCTGV SSLPQPLPRV FLSFEDLQAS ESFEHYSISD
KAMDYRLLQM DEDQDRMYVG CKDHVLSMDI NNITHGTLKL FWPASTSKIE ECQMAGKDPT
HGCGNFIRVV QPYNRTHLFM CGSGAYSPVC VYVNRGRRPE EQVFHIDSRT ESGKGRCSFN
PQVNTVSVML NQELFSGMYI DFMGTDAAIF RSLTKRNAVR TDQHNSKWLS EPIFIDAHLI
PDGTDPNDSK LYFFFRERLT DNSGNTKNIH TMVARVCPND IGGQRSLVNK WTTFLKARMV
CSVVEEDGTE THFDELESVF LLETDLPKGL LVFGVFTSTS SVFKGSAVCV YNMADILTVF
NGPFAHREGP NFQWIAFQGR IPYPRPGTCP GGAFTPDIQT TKEFPDDVVT FVRNHPVMFN
AIYPVGRRPL VVRTNADYKY TAVAVDQVMA ADGNYQVLFL GTDKGTIQKV IVLPSNHSLH
DDLILEELEV FKNKAPVTNL RISSKKQQLY ASSEFGVSQV SLHRCQAYGS ACADCCLARD
PYCAWDGLSC SRFYPTGKRR SRRQDIMHGN PLTQCRGFNL KAYRNAVEMT QYGVKNNTTF
LECLPKSPQA SIRWLIQRDN DRRKEVKLSD RVLSTEHGLL IRSVQLSDQG LYYCLTSENG
FKRTVAKIRL HVLSEAMVSM LTDKQQSPWA WTSSLHPKVL LAAFSPAENL AVQQYCKERK
ELKNLQQRQQ QQPSEPPGPL RGDLAKLKPL LDRRKSRNRR NHPED
//
