ID A0A3P9B2P7_9CICH Unreviewed; 777 AA.
AC A0A3P9B2P7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Heterogeneous nuclear ribonucleoprotein U {ECO:0000313|Ensembl:ENSMZEP00005004171.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005004171.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005004171.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005004171.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3P9B2P7; -.
DR Ensembl; ENSMZET00005004344.1; ENSMZEP00005004171.1; ENSMZEG00005003185.1.
DR GeneTree; ENSGT00940000156546; -.
DR Proteomes; UP000265160; LG15.
DR CDD; cd12884; SPRY_hnRNP; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035778; SPRY_hnRNP_U.
DR PANTHER; PTHR12381:SF11; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U; 1.
DR PANTHER; PTHR12381; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER; 1.
DR Pfam; PF13671; AAA_33; 1.
DR Pfam; PF02037; SAP; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00513; SAP; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50800; SAP; 1.
PE 4: Predicted;
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160}.
FT DOMAIN 6..40
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT DOMAIN 216..412
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 41..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 618..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..97
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..127
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 85726 MW; 0F978CF0F84C9F07 CRC64;
MSTINVKKLK VNELKDELKK RNLSDKGLKA ELMDRLQAAL DEEALASPQE QAAEADDGFE
QAADQEGMAE EEEGEGEGEG PIEESMEANE EEEPESGGDG NGVAVDEEMG EGEEEGDEDD
EMDPMLKGDV DDMEKIDTED GEPGEQAAEG ESTESPTSLS QKKEHLILYL CSIFKGDADK
DTNADQKNKK GVKRRREEHG RGYFEFIEEN KYSCASSKSP VPPLEEEDED NDDTKVCLDS
YNSDLHFKVS RDRYSASSLT MESFAYLWSG GKATYGVNKG KACFEMKITE KIPVKHISSK
NMEIHDVQVG WSLETGTLLL GEEEHSYAYS GKAKKTTNCV TEEFGETYEE NDVICCLIDF
EGEEVVLSYS KNGGEPAAAF QVGKDSLNGR ALFPHVICRN CAVEFNFGQL ETPYFPQPQG
YTFLQQIPVS DRVRALKGPQ TKADCEVIMV GLPGSGKTTW VNKHIQENPG KYYILGSDTI
VEKMMIGSMK RQSKDITKLT AISQRAPLFL GKFIEIAARK KRNYILDHTN LSAPGQKRKM
CLFAGFQRKA VVVCPSDEDY KQRVQKKVET DGKEVPEHAL LKMKGFFSLP EEGESFNEVI
YAELQKDDAA KLLEQYKEES KTALPAEKKP NQGSTTPKQR GGQRGAGRGG KNQFARGGGP
GQRGGSRGGF QNRGNFRGAP GPRGGFNRPP RGFLPPPAFR GGFPNRGNFN RGGGPIPSLG
GSPRGGPMRG NMGHRGGPMS RGGPVNRGNM SRGVLMFCSV QFWNQKPWSQ QYQPGYY
//
