ID A0A3P9B4Z8_9CICH Unreviewed; 1043 AA.
AC A0A3P9B4Z8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Protocadherin-11 X-linked {ECO:0000313|Ensembl:ENSMZEP00005004852.1};
GN Name=PCDH11Y {ECO:0000313|Ensembl:ENSMZEP00005004852.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005004852.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005004852.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005004852.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein.
CC {ECO:0000256|ARBA:ARBA00037723}.
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DR RefSeq; XP_004545574.1; XM_004545517.3.
DR AlphaFoldDB; A0A3P9B4Z8; -.
DR Ensembl; ENSMZET00005005064.1; ENSMZEP00005004852.1; ENSMZEG00005003743.1.
DR GeneID; 101473199; -.
DR CTD; 100333121; -.
DR GeneTree; ENSGT00940000158335; -.
DR OrthoDB; 4259465at2759; -.
DR Proteomes; UP000265160; LG2.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 7.
DR Gene3D; 2.60.40.60; Cadherins; 7.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR InterPro; IPR013585; Protocadherin.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF254; PROTOCADHERIN-11 X-LINKED-RELATED; 1.
DR Pfam; PF00028; Cadherin; 6.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF08374; Protocadherin; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 7.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 7.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1043
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018262658"
FT TRANSMEM 817..841
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..139
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 140..249
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 250..355
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 370..466
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 467..570
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 571..673
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 685..789
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 848..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1043 AA; 115087 MW; 98323E5F54F7E78E CRC64;
MDLASQAHVL VVLLTCVVLQ CQAQERDYTV KEEQPENVRI GNLRKDLDLN LDPSIRLSSP
LQFKPVYKTG DVPLVRVEAN TGEIFTTNHR IDREKLCSGV FNEKRCYYEI EVAVLPDEIF
RLVKIRFLIE DVNDNAPLFQ STVINISIPE NTAINTRYPV PSAFDPDVGI NGIQHYELVK
SVSEFGLDII ETPEGDKWPQ LIVQQNLDRE QKDTFVMKIK VEDGGNPPKS STAILQVTIS
DVNDNRPIFK DSELEVTVPE NAPVGTSVAQ LHATDADLGS NAQIHFAFSN QISSSTKRHF
AINSSTGLIT VKQPLDREVT PVHKLIVLAS DGSSTPSRAT VTVNVTDIND NVPSIDTRYI
INLVNGTVLL SENAPLNTKI ALITVTDKDA DLYGKVACYT DHDVPFRLKP VFNDQFLLET
AAPLDYETTR EYAIKIVASD RGTPPLNTSA MVLIKIKDEN DNAPIFPQPE IQLSIPENND
PSTQLIKISA TDADSGHNAE IIYTLSPDAP DGFNIDRRSG ILSVGKRLDR EKQERYSFTV
IARDNGSTSL QSNVTVKLIV QDLNDNSPTF THPEYNFYVP ENLPLYGTVG LITVTDADAG
DNAVVTLSIL NGKDNFIIDP QTGVIKPNIT FDREQQSSYT FMVKAVDGGQ PPSSSYAKVT
INVVDVNDNR PVFVIPSSNY SYDLVRTTTT PGAVVTRVFA IDNDTGMNAE LQYSLISSII
ITSRVSPRGL FAIDKTTGNI TLQEKIVAAD QGLHRLVVKV KDLGQPESLH AIALVHLFVN
DSVSNATFIQ EQLRKSMETP LDRNIGDSEV APQANGYVIV VIAIIAGTMT VILVIFVTAL
VRCRQTPRHK VVQKGKQSGE WVSPNQENRQ IKKKKKRKKR SPKSLLLNFV TIDESKPDDP
THEHVNGTLD LPVELEEQTM GKYNWATTPT TFKPDSPDLA KHYKSASPQP TFQIKPETPV
APKKHHVIQE LPLDNTFVVG CDSLSKCSST SSDPYSVSEC SCQGGFKTAG QSTNRQEMAL
KPPHYGTLCG TGTARSHRIK INL
//
