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Database: UniProt
Entry: A0A3P9B7D9_9CICH
LinkDB: A0A3P9B7D9_9CICH
Original site: A0A3P9B7D9_9CICH 
ID   A0A3P9B7D9_9CICH        Unreviewed;        68 AA.
AC   A0A3P9B7D9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Copper transport protein ATOX1 {ECO:0000256|ARBA:ARBA00040962};
DE   AltName: Full=Metal transport protein ATX1 {ECO:0000256|ARBA:ARBA00043201};
OS   Maylandia zebra (zebra mbuna).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX   NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005005818.1, ECO:0000313|Proteomes:UP000265160};
RN   [1] {ECO:0000313|Ensembl:ENSMZEP00005005818.1, ECO:0000313|Proteomes:UP000265160}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA   Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA   Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA   Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA   Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA   Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA   Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA   Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA   Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA   Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA   Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA   Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid fish.";
RL   Nature 513:375-381(2014).
RN   [2] {ECO:0000313|Ensembl:ENSMZEP00005005818.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Binds and deliver cytosolic copper to the copper ATPase
CC       proteins. May be important in cellular antioxidant defense.
CC       {ECO:0000256|ARBA:ARBA00037651}.
CC   -!- SIMILARITY: Belongs to the ATX1 family.
CC       {ECO:0000256|ARBA:ARBA00038171}.
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DR   RefSeq; XP_004552129.1; XM_004552072.3.
DR   RefSeq; XP_014264935.1; XM_014409449.1.
DR   AlphaFoldDB; A0A3P9B7D9; -.
DR   STRING; 106582.ENSMZEP00005005818; -.
DR   Ensembl; ENSMZET00005006071.1; ENSMZEP00005005818.1; ENSMZEG00005004498.1.
DR   GeneID; 101473524; -.
DR   KEGG; mze:101473524; -.
DR   CTD; 475; -.
DR   GeneTree; ENSGT00940000163780; -.
DR   OrthoDB; 1107952at2759; -.
DR   Proteomes; UP000265160; LG2.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   CDD; cd00371; HMA; 1.
DR   Gene3D; 3.30.70.100; -; 1.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   PANTHER; PTHR46365; COPPER TRANSPORT PROTEIN ATOX1; 1.
DR   PANTHER; PTHR46365:SF1; COPPER TRANSPORT PROTEIN ATOX1; 1.
DR   Pfam; PF00403; HMA; 1.
DR   SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR   PROSITE; PS50846; HMA_2; 1.
PE   3: Inferred from homology;
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          1..63
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
SQ   SEQUENCE   68 AA;  7636 MW;  84B674C95E6260CB CRC64;
     MTKHEFEVAM TCEGCSGAVT RILNKMGDVK FEIDLPKKLV WIESDKDVDV LMTALQKSGK
     EVKYNGTK
//
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