ID A0A3P9B869_9CICH Unreviewed; 4000 AA.
AC A0A3P9B869;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=FAT atypical cadherin 2 {ECO:0000313|Ensembl:ENSMZEP00005006022.1};
GN Name=FAT2 {ECO:0000313|Ensembl:ENSMZEP00005006022.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005006022.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005006022.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005006022.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 106582.ENSMZEP00005006022; -.
DR Ensembl; ENSMZET00005006289.1; ENSMZEP00005006022.1; ENSMZEG00005004584.1.
DR GeneTree; ENSGT00940000158507; -.
DR Proteomes; UP000265160; LG2.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 28.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 30.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF448; FAT ATYPICAL CADHERIN 2; 1.
DR Pfam; PF00028; Cadherin; 25.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 28.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 29.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS00232; CADHERIN_1; 12.
DR PROSITE; PS50268; CADHERIN_2; 29.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..4000
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018191402"
FT TRANSMEM 3703..3723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..152
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 153..260
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 364..459
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 460..565
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 566..687
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 710..814
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 815..919
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 920..1026
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1027..1131
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1132..1298
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1299..1396
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1397..1510
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1506..1606
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1607..1708
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1709..1809
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1810..1910
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1911..2017
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2018..2119
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2120..2223
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2224..2330
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2331..2436
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2437..2548
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2549..2654
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2655..2756
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2757..2861
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2862..2965
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2966..3070
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3071..3175
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3194..3250
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3410..3587
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3589..3626
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3628..3664
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 3766..3806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3952..4000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3784..3799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3959..3988
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3616..3625
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3654..3663
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4000 AA; 440965 MW; E1BD116942635AE5 CRC64;
MMAASGAILL VFASVLTCVT RSEGSYRLGK GSSPLLFTHH LYNAAINENS APRMYVETQV
KMGIEVTDPL WDIKYNIVSG DDDSFFKAEA VKVGNFCFLR IKTRSSNSAL LNREVRDSYT
LTVEAKESTF GFEAMTKVFV QVLDTNDLKP LFYPASYNVA IREDAPLKSS VTKVSATDAD
IGSNAEFYYS FTSRAHPFVV DPFTGTVSLI KRLNHTRAQR YDLTVLAEDR TKKISGVQKF
GNVARVTVNI QKMTMASPVI TPPPEATVSA DGKIDINVHV EEGVKPVESL NIIGGDPHKW
FEVIPSGVQG SDFQVISTKR IIWSQARFGL NLSLQAKDRS LPSFLSPITQ IHIPAYHYSP
LAFLEDTYIV TLSEFSPPQT HVLKVSVTSV PFNVTFSIKN NPDTSNFKIN PKTGIIITTG
KFDYERKDRY EFDVMANHGE AETHIVVEIT DENDNSPEFT QTSYQATLDE NSPVGSSVLK
VAASDKDKGK NGFVTYAIAN SGPLPFTIDP FTGIISTSEH LDYELMKRRY HLRVWASDSG
GPFSQVSESP VTITLNNIND NIPLFEQVGC NVTVPLDLPV GHEVAKLSAI DLDELQQLRY
VIESGNELQV FGINSVTGVI ALKQPIPLLQ GSFTLRVVAT DGKHHSEASV VRITITNRGE
DRTLHCKETG IAKQVTDKLI KSIKPILINQ EEDTFSDIHI TNRHSPKFDT SIPSSIDLVE
NHPLNSTIVQ FKATDNDSGF NSKLVYAISS GNEDGCFSID TFSGDLRLVC PLDRERKGFY
ILNITVYDLG IPQTSAWKFI AVNIMDVNDN PPVFDQPRYV IHVPENKEVN SVIFTCRTAD
LDSDMSGKVQ YSLLTMTDMF RMDEFTGELI VTGRLDRESS PKHDLLIEAR DQATVGPQLF
STVNLVVILQ DINDNPPKFV PKVHKIKVPE DVPVGTLLVW VDSMDLDLGS GGLVTYNLKN
TESGIFHLDS STGALTLERE LDFERRPSYN LTVWAVDHGL PRSLSSSCFV EIEVLDVNEN
LHRPVFSEFV YEALVKEDSA VGTSVVTLTA SDKDLGRDGV VRYHIHDGSG LGVFTIDEEA
GVIRMTEMLD RETAPHYWLS VYATDLGTEP LITWTHVFIE VLDINDNAPE LSQPMYFASV
PENVDTVESV IKVSATDVDT SSEGKLSFQM LESHRLHFDI DPNTGEYSSM KNIIKGDLDE
FQHVISCELS QSQTEVFYQW DILFVSNFLF CVPAGNIDNV FNIDPDLGSI SVSKSLDLQP
QDLFHLTVKA TDQGFPQRSD LCSVHIHVRV SEQTPPTFLS DDYLTEISEL SAIGTPVVTV
SASSPAAVHY EIESGNRNGT FYINSYTGLI STQGRLDYET CDSYKLRVTA STTAGAVSRT
VVHIYVVDEN DNAPVFEQRE YQGQIGESAH INSMVMGERN TPLVIRASDS DRDSNSLLTY
QILEPEALKV FRIDSSMGTI SLISLLDFET KAEYHFTVQV KDSGEPSLYA AEPAKVTVRI
LDLNDCPPQF TASVYESSII LPAVRDAEVV CITAYDADSA VSYSITEGNL HNAFSIHPNT
GLITVNNVSD FRPFYQLHVK AFDGLYRDLA IVNVSVTNLT ESDLRFEHKV YSASVSENIK
TVKTLAALKV TGCFLNEPLL YSVLNPAGRF TICPTAGLLE TTGVPFDREE QDVYDVVVKV
QDMRTPPRTA ITKVKVFIDD VNDNLPQFLN LPFSMMISED AEPGDVLYQV TAIDRDLGEN
GAIVYNLEED YGLFRIDPDI GDVSLQRPLD FNALNKYVLT VSAIDEGEPS HSIMAQLSIQ
VRNRTNPVFQ TLLYPLKVPE DVPPFTTILH VQARNPEGYR LIYNLEEENA SKHFHIDFKT
GVLTVTNPLD YESQTMHVLI VRATDSVTGA FSEASIEIEV EDVNDNAPVF SKLMHNVNIA
EGLPVDTSVI KLSASDKDSG RNKDLTFHMV KTHGDESDFF KINSQTGLIV TKQVLDYESR
KHFNLKIKAT DNGTIPLSSE TFVTINVTDV NDNPPDFDSS RYKATLDEMA KCGHIVIKIQ
ASDPDTGDLN NLKYKILSGN EGRYFNINES SGIISFSNVC RRNLDPHYNL TVAVSDGVFQ
KTAPVSIDMI NSNRHNPYFK QSVYEAELAE NAEAGTRVIR LAAIDPDDGP YGSVDYTIIN
KLADEKFAIS KDGQIVTTQP LDRENPSQRV IAIKVMAKDG GGKVAFCTVK IILTDENDNV
PQFKASEYQV SIQSTVNKGS PVIQIMAYDA DDGKNADVTY LVDEAEEVTE DIIEINPFTG
VVSVKESLVG MENKIFNFKV KARDGSLPFY NSTVPVQVKV VPPEVPLPKF SEPLYTFSAA
EDIPIGTEIG AVRADSDMPL IYSLVNGNTV ESNKDKVFSL DQESGTLLLQ KSIDHEKTKW
YQIDVIAQGN HNGTDVASLV SVSIQVQDVN DNQPVFDASP YRAFLAENMP AGTTVIQVTA
NDPDTDTNGV VTYTLEPLPD DTALDITEVF SIDGESGWIT TLRETDCEAT RVYRFNVVAT
DHGGNAKLSS SVLVEVMVTD ENDNPPKFTE EVYRGSVVEN STPYEPIVYM TTTDADVSLE
NRLITCYITA GDPLGQFAIV QVDEGQWGLI VKESLDREAR DRYALRVTAT DGKFEAPISV
DVHVLDINDN SPLCEQLVYK EVVMENSPSS VFVLKVSASD PDVGTNGQIS YTLHGPDADK
FHLEHRTGEL FTLAVLDRER NVEFNLVAKA TDGGGRSCQA DILLMVQDMN DNPPRFSSSH
YEVTVFDNTT VRTPVAVVYA KDPDTGINSE VKYSLLSGDD GYFSLDEFSG ILRLERPLNP
ETPTTFELKV KATDRGLPRH LHSVATVTVD VVSLDDYQPV FMSSEYTAQL PESSAVGSEV
LSVSALTRDS SSPDPIVYRI ISGNEDGRFQ LDSRTGLVTL VAPLDFEVSR EYYLSVEGSR
GKSPLSDIAT VIINVTDVND NPPVFGRSDY SAEVLEDLSP GRLVMKVTAT DEDGPVNNLL
RYSIVSGDLL QQFSVDARSG DITVRTALDR EEIPHYSLTV QAADEGSPPL SSAVLVAVTV
NDVNDNPPVF SQVNHSLLLQ EGEAVGSSIL QLVVTDKDTP RNGPPFSFHI VSGNEDRRFH
VDQGGLLSLS APLRKKVKAH HQLKIQVTDS GHPPLSSICV VNINVTEESK YPPSVVPLEV
SITTSGGLFA NRVVGRLHAS DQDVQDVLTY SLVSQSPDGR SFSVDQADGK IWADEHLEEG
SYALNISVSD GKFTVWTGVK VHVWVATQQA LDSGLTLQLV GMSPEEFLGD HWRGLQRSLG
QELDLPRQEL HLASLQQRPD PRALEALLIW RPQGGPVRPL PTSRLAGESD SLGLSILRVS
HNGCLGSGCP PRGCRNSVRL SGERLGHFTT ARATYITPQH TWESACPCNQ SALRFVSRSY
LRYLHRKDED NQDFKLSLRF KTIEKQGVIV STNSSTGWGA LQVWMHLRYL LFRYRCGTTT
PASLPIGSHM VSDGRWHSVL LEVNSSSLRL TLDGQHPVSA SSVEPCQMLR SHGALLFGSP
PELHQQPHNF SGCLEGLELN GEPIRTGDSA EWRGSGSRRV FGVYQCCSGG GACDSSPCKN
GGVCEEDATG EPRCRCAGLF HGARCELTDN PCASQPCTHG RVCMPMDQGY LCNCSRENPE
ARCQDTGCSP NECPQGFGCK VTNGAIYCEP LPLVNPSFGY MEIIQIGAGV LGLVFLVGVF
VCIRKRHVQQ KKKKPICVQD SNGYLQSSLA KSLKANSQEV NPIEMSSLVG PTNDLDHTPF
RSLRPRSQIG SSAGGSPKTQ GPVVCSVAPN LPVRPPSSSD NDSIRKNHWD LDYEVYPADP
DYYGRPAVQD FPQFDIVEDT YSTSTMDSRR NSRFGGFPFP LDRCDRRAPL PPCYSNQNLD
DFLGPDGLPL PSSQCPNEYT AISYYPTQHT RSLDNVTGYK RLSMRLSVAM PSYAEQASPP
PAPNLNQAQP QTRKARQNPR SCDGSSMVES DYGSCEEVMF
//
